Protein Alignment Klp3A and Kif27

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_780423.2
• Gene: Kif27 / 75050
• MGIID: 1922300
• Length: 1394
• Species: Mus musculus
• Alignment Length: 1449
• Identity: 338/1449 - (23%)
• Similarity: 598/1449 - (41%)
• Gaps: 390/1449 - (26%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            :.||:|:|||:..|:....::.| |......|:.:.|:..:|:::||..:.:|.:::.||::..|
Mouse     6 IKVAVRIRPLLCKEVLHNHQVCV-RDIPNTQQIIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLV 69

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTA-FNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRFAVTC 137
            ..|:.|||.|:.||||||||||||:|.. ...|::...|:||||:.:||.:|:|..| ..|.:..
Mouse    70 LSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVEGQKGIIPRAIQEIFQSISENPS-IDFKIKV 133

  Fly   138 SFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAA 201
            |::|:|:|...||...:|..| .:.||| .|...::.|..|..|.|.:.|...|..|:|.|....
Mouse   134 SYIEVYKEDLRDLLELETSMK-DLHIREDEKGNTVIVGAKECQVESVEDVMSLLQVGNAARHTGT 197

  Fly   202 TAMNETSSRSHAIFTLTLVATKLDGKQSVT---------TSRFNLVDLAGSERCSKTLASGDRFK 257
            |.|||.|||||||||:::...:.:.:.:..         .|:|:.||||||||.:||..:|:|||
Mouse   198 TQMNEHSSRSHAIFTISVCQVEKNAEAAENGEWYSHRHIVSKFHFVDLAGSERVTKTGNTGERFK 262

  Fly   258 EGVNINKGLLALGNVINALGS-GQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAE 321
            |.:.||.|||||||||:|||. .:.:.:||||.:|:||||:|||||::.|:||.||||:..:..|
Mouse   263 ESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSDFDE 327

  Fly   322 TLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAI 386
            :|::|:||:||..|:|||.:|:.|.|..::.::..|:.||..|.|    ..:.||....|....:
Mouse   328 SLNSLKYANRARNIRNKPALNISPQADRMDEMEFEIKLLREALQS----HQASISQASQASSENV 388

  Fly   387 PCEESLAGSMANAAEIQR------------------LKEQVRTLQDRNRKLQ------QELHQSL 427
            |.:..:.......|::|.                  ||:.|:..|.:..|||      ||:.:::
Mouse   389 PDQNRIHSLEEQVAQLQEECLGYQDCIEQAFAFLVDLKDAVKLNQKQQHKLQEWFSRTQEVRKAV 453

  Fly   428 L---------------------------------------------DLTEKEMRAHIAEQAHDKL 447
            |                                             ||..:|:|..:.....:.
Mouse   454 LTPLPGNQGIGNLEEGPQHLTVLQLKRELKKYQCALAADQVVFTQKDLELEELRTQVQLMMQES- 517

  Fly   448 RSHVSELK-----NKLDQRE-----------QAQFGNENTN---------GD------NEMR--- 478
            :.|...||     |:|...:           .|:....:.:         ||      :|.|
Mouse   518 KGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSAELAKRSLSVPTSAKESCGDGPDARASEKRPHT 582

  Fly   479 -----------------DFSLLVNR------------------------------VHVELQRTQE 496
                             ||..:.:.                              :|.:.....:
Mouse   583 APFESHWGHYVYIPSRQDFKKVCSSTPVYSLDQVFAGFRTRSQMLMGHLEDQDEVLHCQFSDNSD 647

  Fly   497 ELESQGHESRQRLSSRSHTEGGESG----------------------GDEVHEMLHSH------- 532
            :.:|:|.| :.|:.||||:...:.|                      ||...|.|...
Mouse   648 DEDSEGQE-KPRVRSRSHSWAKKPGSVCSLVELSDTQAESQRSYLGNGDLKMESLQESQEINLQK 711

  Fly   533 ---SEEYTNKQMNFAGELRNINRQLDLKQELHERIMR--NFSRLDSDDEDVKLRLCNQKIDDLEA 592
               ||...||...   ::|.:...:.:|::|.:.:::  |.::..|....:|:.....:.:..:.
Mouse   712 LRTSELILNKAKQ---KMRELTINIRMKEDLIKELIKTGNNAKSVSRQYSLKVTKLEHEAEQAKV 773

  Fly   593 ERRDLMDQLRNIKSKDIS-----AKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKI 652
            |..:...||:.::|||:|     .||.:|.||::...:..:..|::|......|..:..:..::.
Mouse   774 ELTETRKQLQELESKDLSDVALKVKLQKEFRKKMDAAKMRVQVLQKKQQDSKKLASLSIQNEKRA 838

  Fly   653 QNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQ 717
            ..|...:..:|..||:|.|.:|.|.||.:|                  :.:||.|.|    ::.:
Mouse   839 SELEHNVDHLKYQKVQLQRRLREEGEKKKQ------------------LDAEIKRDQ----QKIK 881

  Fly   718 VLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLI 782
            .|:.|..:....|.:.:|    |......|.|.....|......:...|   |:|.|:|.:||
Mouse   882 ELQLKAGQGEGLNPKAED----QDGFNLNRRKSPFRSGDQFQKLDEQRK---WLDEEVEKVLS-- 937

  Fly   783 DAEHSLEQLMED----RAVINNHYHLLQQEK-------TSDPAEAAEQARILAS---LEEELEMR 833
             ....||.|.||    .|:::....|||::.       .|..|.:.:..:|.|.   |::||..:
Mouse   938 -QRQELEMLEEDLKKREAIVSKKEALLQEKSLLENKKLRSSQALSTDGLKISARLNLLDQELSEK 1001

  Fly   834 NAQI--SDLQQKVCPTD------------------LDSRIR--------------SLAEGVQSLG 864
            :.|:  |..::|:..::                  :|.|::              .|.||:::|.
Mouse  1002 SLQLESSPTEEKMKISEQVQALQRERDQLQRQRNSVDERLKHGRVLSPKEEHLLFQLEEGIEALE 1066

  Fly   865 ESRTVSKQLLKTLVQQRRLQASSLNEQRT-----------TLDELRA----------QLLDAQQQ 908
            .:.....:.:::  :|..|:||..|..::           .:.|:||          .|.:.:::
Mouse  1067 AAIEFKNESIQS--RQNSLKASFQNLSQSEANVLEKLVCLNITEIRAILFKYFNKVINLRETERK 1129

  Fly   909 EDAASKRLRL------------------LQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSP 955
            :...:|.:::                  |:.|.:.::..||:.:|:|:.:|::           .
Mouse  1130 QQLQNKEMKMKVLERDNVVHELESALEHLRLQCDRRLTLQQKEHEQKMQLLLQ-----------H 1183

  Fly   956 AEDQQRNQILEELLSSREALQQ-ELD-----------KLRAKNKSKSKA----VKSEPQDLDDSF 1004
            .:||..:.|:|.|.:..:.:|| |.|           |.|.|:.::..|    ..:|..|..|.
Mouse  1184 FKDQDGDSIIETLKNYEDKIQQLEKDLYFYKKTSRDLKKRLKDPAQGAAQWQRTLTEHHDAGDG- 1247

  Fly  1005 QIVDGNETVVLSDVSDDPDWVPSTSKSK------RIQSDSRNVISPPEKQDANVTSLGNSSIQSL 1063
             :::..||.||   |::..|...|..:|      .:.:.|.::.:.|..|  .:...|..|:.:.
Mouse  1248 -VLNPEETTVL---SEELKWASRTENTKLNGSEREVDNSSSSLKTQPLTQ--QIPEDGPDSLPAR 1306

  Fly  1064 NSTSATEDGKRCKGCKCRTKCTT-------------KRCGCLSGNNACSETCVCKSNCRNPLNLK 1115
            :|.:.:....:....|...:..|             :..|.|.|   .....:|:...|....::
Mouse  1307 SSIAPSSGQLQSIADKTEARPFTHSQSPVPHQFQPVRSIGPLQG---VKPVKLCRRELRQISAME 1368

  Fly  1116 DHASQCGDGDGQKDETEDA 1134
            ....:|..|.|.:..|.|:
Mouse  1369 LSLRRCSLGAGGRSMTADS 1387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	141/338 (42%)
		Smc	<453..>985	CDD:440809	133/750 (18%)
		Metallothio	<1071..1115	CDD:395080	7/56 (13%)
Kif27	NP_780423.2	KISc_KIF4	4..342	CDD:276823	141/338 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..582		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..665		7/23 (30%)
		SMC_prok_B	<763..1090	CDD:274008	74/360 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..916		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1267..1319		8/53 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1325..1344		1/18 (6%)