DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Kif27

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_780423.2	Gene:	Kif27 / 75050	MGIID:	1922300	Length:	1394	Species:	Mus musculus

Alignment Length:	1449	Identity:	338/1449 - (23%)
Similarity:	598/1449 - (41%)	Gaps:	390/1449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            :.||:|:|||:..|:....::.| |......|:.:.|:..:|:::||..:.:|.:::.||::..|
Mouse     6 IKVAVRIRPLLCKEVLHNHQVCV-RDIPNTQQIIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLV 69

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTA-FNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRFAVTC 137
            ..|:.|||.|:.||||||||||||:|.. ...|::...|:||||:.:||.:|:|..| ..|.:..
Mouse    70 LSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVEGQKGIIPRAIQEIFQSISENPS-IDFKIKV 133

  Fly   138 SFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAA 201
            |::|:|:|...||...:|..| .:.||| .|...::.|..|..|.|.:.|...|..|:|.|....
Mouse   134 SYIEVYKEDLRDLLELETSMK-DLHIREDEKGNTVIVGAKECQVESVEDVMSLLQVGNAARHTGT 197

  Fly   202 TAMNETSSRSHAIFTLTLVATKLDGKQSVT---------TSRFNLVDLAGSERCSKTLASGDRFK 257
            |.|||.|||||||||:::...:.:.:.:..         .|:|:.||||||||.:||..:|:|||
Mouse   198 TQMNEHSSRSHAIFTISVCQVEKNAEAAENGEWYSHRHIVSKFHFVDLAGSERVTKTGNTGERFK 262

  Fly   258 EGVNINKGLLALGNVINALGS-GQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAE 321
            |.:.||.|||||||||:|||. .:.:.:||||.:|:||||:|||||::.|:||.||||:..:..|
Mouse   263 ESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSDFDE 327

  Fly   322 TLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAI 386
            :|::|:||:||..|:|||.:|:.|.|..::.::..|:.||..|.|    ..:.||....|....:
Mouse   328 SLNSLKYANRARNIRNKPALNISPQADRMDEMEFEIKLLREALQS----HQASISQASQASSENV 388

  Fly   387 PCEESLAGSMANAAEIQR------------------LKEQVRTLQDRNRKLQ------QELHQSL 427
            |.:..:.......|::|.                  ||:.|:..|.:..|||      ||:.:::
Mouse   389 PDQNRIHSLEEQVAQLQEECLGYQDCIEQAFAFLVDLKDAVKLNQKQQHKLQEWFSRTQEVRKAV 453

  Fly   428 L---------------------------------------------DLTEKEMRAHIAEQAHDKL 447
            |                                             ||..:|:|..:.....:.
Mouse   454 LTPLPGNQGIGNLEEGPQHLTVLQLKRELKKYQCALAADQVVFTQKDLELEELRTQVQLMMQES- 517

  Fly   448 RSHVSELK-----NKLDQRE-----------QAQFGNENTN---------GD------NEMR--- 478
            :.|...||     |:|...:           .|:....:.:         ||      :|.|
Mouse   518 KGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSAELAKRSLSVPTSAKESCGDGPDARASEKRPHT 582

  Fly   479 -----------------DFSLLVNR------------------------------VHVELQRTQE 496
                             ||..:.:.                              :|.:.....:
Mouse   583 APFESHWGHYVYIPSRQDFKKVCSSTPVYSLDQVFAGFRTRSQMLMGHLEDQDEVLHCQFSDNSD 647

  Fly   497 ELESQGHESRQRLSSRSHTEGGESG----------------------GDEVHEMLHSH------- 532
            :.:|:|.| :.|:.||||:...:.|                      ||...|.|...
Mouse   648 DEDSEGQE-KPRVRSRSHSWAKKPGSVCSLVELSDTQAESQRSYLGNGDLKMESLQESQEINLQK 711

  Fly   533 ---SEEYTNKQMNFAGELRNINRQLDLKQELHERIMR--NFSRLDSDDEDVKLRLCNQKIDDLEA 592
               ||...||...   ::|.:...:.:|::|.:.:::  |.::..|....:|:.....:.:..:.
Mouse   712 LRTSELILNKAKQ---KMRELTINIRMKEDLIKELIKTGNNAKSVSRQYSLKVTKLEHEAEQAKV 773

  Fly   593 ERRDLMDQLRNIKSKDIS-----AKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKI 652
            |..:...||:.::|||:|     .||.:|.||::...:..:..|::|......|..:..:..::.
Mouse   774 ELTETRKQLQELESKDLSDVALKVKLQKEFRKKMDAAKMRVQVLQKKQQDSKKLASLSIQNEKRA 838

  Fly   653 QNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQ 717
            ..|...:..:|..||:|.|.:|.|.||.:|                  :.:||.|.|    ::.:
Mouse   839 SELEHNVDHLKYQKVQLQRRLREEGEKKKQ------------------LDAEIKRDQ----QKIK 881

  Fly   718 VLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLI 782
            .|:.|..:....|.:.:|    |......|.|.....|......:...|   |:|.|:|.:||
Mouse   882 ELQLKAGQGEGLNPKAED----QDGFNLNRRKSPFRSGDQFQKLDEQRK---WLDEEVEKVLS-- 937

  Fly   783 DAEHSLEQLMED----RAVINNHYHLLQQEK-------TSDPAEAAEQARILAS---LEEELEMR 833
             ....||.|.||    .|:::....|||::.       .|..|.:.:..:|.|.   |::||..:
Mouse   938 -QRQELEMLEEDLKKREAIVSKKEALLQEKSLLENKKLRSSQALSTDGLKISARLNLLDQELSEK 1001

  Fly   834 NAQI--SDLQQKVCPTD------------------LDSRIR--------------SLAEGVQSLG 864
            :.|:  |..::|:..::                  :|.|::              .|.||:::|.
Mouse  1002 SLQLESSPTEEKMKISEQVQALQRERDQLQRQRNSVDERLKHGRVLSPKEEHLLFQLEEGIEALE 1066

  Fly   865 ESRTVSKQLLKTLVQQRRLQASSLNEQRT-----------TLDELRA----------QLLDAQQQ 908
            .:.....:.:::  :|..|:||..|..::           .:.|:||          .|.:.:::
Mouse  1067 AAIEFKNESIQS--RQNSLKASFQNLSQSEANVLEKLVCLNITEIRAILFKYFNKVINLRETERK 1129

  Fly   909 EDAASKRLRL------------------LQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSP 955
            :...:|.:::                  |:.|.:.::..||:.:|:|:.:|::           .
Mouse  1130 QQLQNKEMKMKVLERDNVVHELESALEHLRLQCDRRLTLQQKEHEQKMQLLLQ-----------H 1183

  Fly   956 AEDQQRNQILEELLSSREALQQ-ELD-----------KLRAKNKSKSKA----VKSEPQDLDDSF 1004
            .:||..:.|:|.|.:..:.:|| |.|           |.|.|:.::..|    ..:|..|..|.
Mouse  1184 FKDQDGDSIIETLKNYEDKIQQLEKDLYFYKKTSRDLKKRLKDPAQGAAQWQRTLTEHHDAGDG- 1247

  Fly  1005 QIVDGNETVVLSDVSDDPDWVPSTSKSK------RIQSDSRNVISPPEKQDANVTSLGNSSIQSL 1063
             :::..||.||   |::..|...|..:|      .:.:.|.::.:.|..|  .:...|..|:.:.
Mouse  1248 -VLNPEETTVL---SEELKWASRTENTKLNGSEREVDNSSSSLKTQPLTQ--QIPEDGPDSLPAR 1306

  Fly  1064 NSTSATEDGKRCKGCKCRTKCTT-------------KRCGCLSGNNACSETCVCKSNCRNPLNLK 1115
            :|.:.:....:....|...:..|             :..|.|.|   .....:|:...|....::
Mouse  1307 SSIAPSSGQLQSIADKTEARPFTHSQSPVPHQFQPVRSIGPLQG---VKPVKLCRRELRQISAME 1368

  Fly  1116 DHASQCGDGDGQKDETEDA 1134
            ....:|..|.|.:..|.|:
Mouse  1369 LSLRRCSLGAGGRSMTADS 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	141/338 (42%)
		Kinesin	14..335	CDD:278646	139/332 (42%)
		Smc	<396..>994	CDD:224117	152/889 (17%)
		FlaC	522..633	CDD:225888	27/127 (21%)
		TCR	1075..1110	CDD:281618	6/47 (13%)
Kif27	NP_780423.2	KISc_KIF4	4..342	CDD:276823	141/338 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..582		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..665		7/23 (30%)
		Smc	721..>1096	CDD:224117	82/411 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..916		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1319		8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1325..1344		1/18 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820