Protein Alignment Klp3A and Kif18b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_932063.2
• Gene: Kif18b / 70218
• MGIID: 2446979
• Length: 834
• Species: Mus musculus
• Alignment Length: 853
• Identity: 224/853 - (26%)
• Similarity: 367/853 - (43%)
• Gaps: 165/853 - (19%)

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVE-----------RSADG------------APQVT 42
            |:.|| |.|.|.:||||....||:...|..::           ...||            .|: .
Mouse     3 MAVED-SVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSHNGPK-K 65

  Fly    43 VNRNESYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVL 106
            ..::.::.::.||....:|:|:|:......:...|.|||.::.|||.||:|||:|| |.
Mouse    66 KGKDLTFVFDRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGR------ 124

  Fly   107 DDHVGVIPRAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR-I 170
            :...|::.....:::..:...|.|.:|.|..|::|:|.||.:||.    ..|..:.|||..:: :
Mouse   125 EGEPGIMYLTTMELYRRLEARQEEKQFEVLISYLEVYNEQIHDLL----EPKGPLTIREDPDKGV 185

  Fly   171 IMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTL-VATKLDG-KQSVTTS 233
            ::|||:.....||:|:.:.|.||:..|....|..|.|||||||||.:.: ...::.| .|::..:
Mouse   186 VVPGLSFHQPASAEQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVA 250

  Fly   234 RFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQA-AGYIPYRQSKLTRLLQ 297
            :.:|:|||||||.|.|.|.|:|.:||.|||:.||||.||:|||...:. ..::|||.|||||||:
Mouse   251 KMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLK 315

  Fly   298 DSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIK---NKPVVNLDPH-----------AA 348
            ||:|||..|:|||.:||:.....:|.:||:|||||.:|:   ...|:::|.|           .|
Mouse   316 DSIGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQQLQA 380

  Fly   349 EVNMLKDVIQKLRV--------------ELLSGGKMSSSLISAVGAAGLGAIPC--------EES 391
            ||..|::.:|....              .|.....:|||.:....::....:.|        |||
Mouse   381 EVAFLREKLQMYEAGAQALQQQCSPQPPTLSIPQSLSSSSLQPGPSSQSSTLECHAKNETLQEES 445

  Fly   392 LAGSMANAAEI--QRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSEL 454
            | ||.|...||  :...||.:..||:....|:. ..:|.......::|......|...:......
Mouse   446 L-GSDAQGQEIVEESASEQEQCPQDKQCPTQKP-EPNLPGSPSPSVQAKPGTGQHSPQKQDADHS 508

  Fly   455 KN------KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRS 513
            |.      :|.||:.:.....|....:.:.:|..|...|      .:|.::.:....|....:|
Mouse   509 KQLALQVLRLAQRQYSLLQAANLLTPDMISEFETLQQLV------LEESVDHRAESPRSPALAR- 566

  Fly   514 HTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGEL-RNINRQLD--------------LKQELHER 563
                    ||.:.:.|.|.|     |...:.|.: |.:.:||:              ...:..::
Mouse   567 --------GDPLAQALCSES-----KSSGYCGPVTRTMAKQLNGLTHTLGAPLAPDCTSDKTFQK 618

  Fly   564 IMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRN---IKSKDISAKLAEERRKRLQLLE 625
            ..:...|..:.:|...|...|.   :::.:|:..:..||.   .|::..|.....:|       |
Mouse   619 PTKEKKRKLTPEEPGSLPAPNL---EMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKR-------E 673

  Fly   626 QEISDLRRKLITQANLLKIR-DKEREKIQN-----------LSTEIRTMKESKVKLIRAMRGESE 678
            :..|......:..|.::|.| ......:||           |:|.....:||..|      ...:
Mouse   674 RASSPSPSSRVCPATVIKSRVPLGPSALQNCSTPLALPTRDLNTTFNVSEESPSK------PSFQ 732

  Fly   679 KFRQWKMVREKELTQLKSKDRK-MQSEIVRQQTLHSKQRQVLKRKCEEALAANKR--LKDALERQ 740
            :|..|    ||...:|.|.|:. :.|..|   .:.:|.|   |.......|:.||  ::.::.|.
Mouse   733 EFVDW----EKVSPELNSTDQPFLPSAPV---FIFTKGR---KPSLPAVTASKKRRTMRPSVSRG 787

  Fly   741 ASAQAQRH 748
            .|..|:.|
Mouse   788 RSCIARLH 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	128/356 (36%)
		Smc	<453..>985	CDD:440809	62/335 (19%)
		Metallothio	<1071..1115	CDD:395080
Kif18b	NP_932063.2	KISc_KIP3_like	18..353	CDD:276821	122/345 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..508		22/109 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..642		4/42 (10%)
		Nuclear localization signal. /evidence=ECO:0000250	619..627		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..686		5/37 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..834