Protein Alignment Klp3A and KIF13A

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_071396.4
• Gene: KIF13A / 63971
• HGNCID: 14566
• Length: 1805
• Species: Homo sapiens
• Alignment Length: 1316
• Identity: 321/1316 - (24%)
• Similarity: 512/1316 - (38%)
• Gaps: 454/1316 - (34%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGA----PQVTVNRNES-----YTYNYVF-DIDDS--- 60
            |.||:||||:.:.||:...:..||...:..    |.....:.|.     :.::|.| .:|:|
Human     6 VKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTT 70

  Fly    61 ----QKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDI 120
                |:.:|:...:..::|...|||..|.|||||||||::: ||.|      :.:|:|||....:
Human    71 KYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHA------EQLGLIPRLCCAL 129

  Fly   121 FTAIAEMQSEFR-FAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTELVVT 181
            |..|:..|:|.: |.|..|::|:|.|:..||...| ..:.::.:||  ::::.|   ||::|.||
Human   130 FKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPK-GSRQSLKVRE--HKVLGPYVDGLSQLAVT 191

  Fly   182 SAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLD---GKQSVTTSRFNLVDLAGS 243
            |.:.:...:..|:..|.||||.|||.||||||:|.:.:..|..|   |......|:.:|||||||
Human   192 SFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGS 256

  Fly   244 ERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAG-----YIPYRQSKLTRLLQDSLGGN 303
            ||.|||.|:|:|.|||.||||.|..||.||::| :.||||     ::|||.|.||.||:|:||||
Human   257 ERVSKTGAAGERLKEGSNINKSLTTLGLVISSL-ADQAAGKGKSKFVPYRDSVLTWLLKDNLGGN 320

  Fly   304 SITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGG 368
            |.|.|||.:|||..|..||||||||||||.:|.|..|||.||:|..:..|::.::|||.:|
Human   321 SQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQL---- 381

  Fly   369 KMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEK 433
                                      |.|.|.:...|||::    :.:.||.:||..:    .|:
Human   382 --------------------------SQAEAMKAPELKEKL----EESEKLIKELTVT----WEE 412

  Fly   434 EMR--AHIAEQAHDKLRSHVSELKNKLDQREQAQFGNE-----NTNGD---NEM----------- 477
            ::|  ..||::...:|.|....|     :....:.|::     |.|.|   ||:
Human   413 KLRKTEEIAQERQRQLESMGISL-----EMSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRV 472

  Fly   478 -----RDFSLLVNRVHVELQRTQEELESQG----------------------------------- 502
                 :|..|.  .:.::.|..:.::.|.|
Human   473 GADTSQDIQLF--GIGIQPQHCEIDIASDGDVTLTPKENARSCVNGTLVCSTTQLWHGDRILWGN 535

  Fly   503 -HESRQRLSSRSHTE-----GGESGGDEVHEMLHSHSE--------------EYTNKQMNFAGEL 547
             |..|..|..|...:     ..|:|..| |: |.:.||              |...|.:|....:
Human   536 NHFFRINLPKRKRRDWLKDFEKETGPPE-HD-LDAASEASSEPDYNYEFAQMEVIMKTLNSNDPV 598

  Fly   548 RNINRQLDLKQELHE-RIMRNFSRLDSDDEDVKLR----------------------LCNQKIDD 589
            :|:.:.|: ||.|.| |......||..:.|..:||                      ...||:..
Human   599 QNVVQVLE-KQYLEEKRSALEEQRLMYERELEQLRQQLSPDRQPQSSGPDRLAYSSQTAQQKVTQ 662

  Fly   590 LEAERRDLMDQ-LRNIKSKDISAK--------LAEERRK------RLQLLEQEIS-DLRRKLITQ 638
            ...||.:|..| |..::.:.:.|.        ||||..|      .||:....:| :.:|..|..
Human   663 WAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRKRGAIVS 727

  Fly   639 ANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREK--ELTQLKSK---- 697
            ...:::|.|.:      ||::.|:::.:.||| .||   :.:::||   ||  |..:|..|
Human   728 EPAIQVRRKGK------STQVWTIEKLENKLI-DMR---DLYQEWK---EKVPEAKRLYGKRGDP 779

  Fly   698 -----------------------DRKMQ--SEIVRQQ-----TLHSKQRQV-------------- 718
                                   |.|:|  ..|:.||     .||.:..:|
Human   780 FYEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVMRVTGAVPERVVEDDSS 844

  Fly   719 ---------------------LKR-----------------------------KCEEALAA---- 729
                                 :|:                             :||..:||
Human   845 ENSSESGSLEVVDSSGEIIHRVKKLTCRVKIKEATGLPLNLSNFVFCQYTFWDQCESTVAAPVVD 909

  Fly   730 ----NKRLKDA------------------------LERQASAQAQRHKYKDNGGSAAGSSNANAK 766
                :.:.|||                        .:...:.:...|:...||.|.....:.:||
Human   910 PEVPSPQSKDAQYTVTFSHCKDYVVNVTEEFLEFISDGALAIEVWGHRCAGNGSSIWEVDSLHAK 974

  Fly   767 T----DSW--VDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILAS 825
            |    |.|  |.|.:|:.:|:::    |.:|.|..||                           .
Human   975 TRTLHDRWNEVTRRIEMWISILE----LNELGEYAAV---------------------------E 1008

  Fly   826 LEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLV-----QQRRLQA 885
            |.:..::....|..|:|     ....|::...:.||..|....:.:.:|...:     :..:||.
Human  1009 LHQAKDVNTGGIFQLRQ-----GHSRRVQVTVKPVQHSGTLPLMVEAILSVSIGCVTARSTKLQR 1068

  Fly   886 SSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWA 950
            ...:.||   |:.....:|:.|:||                               :....:||:
Human  1069 GLDSYQR---DDEDGDDMDSYQEED-------------------------------LNCVRERWS 1099

  Fly   951 EARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVL 1015
            :|               |:..||.|.:::.|:..|.:.....|:.|.|.::....:.:....|::
Human  1100 DA---------------LIKRREYLDEQIKKVSNKTEKTEDDVEREAQLVEQWVGLTEERNAVLV 1149

  Fly  1016 ----SDVSDDP-DWVP 1026
                |.:...| ||:|
Human  1150 PAPGSGIPGAPADWIP 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	148/356 (42%)
		Smc	<453..>985	CDD:440809	134/792 (17%)
		Metallothio	<1071..1115	CDD:395080
KIF13A	NP_071396.4	KISc_KIF1A_KIF1B	5..359	CDD:276816	151/362 (42%)
		Kinesin_assoc	356..468	CDD:465047	34/154 (22%)
		FHA_KIF13A	446..554	CDD:438781	14/109 (13%)
		SMC_prok_B	<552..>770	CDD:274008	55/233 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..575		7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..656		0/22 (0%)
		KIF1B	748..792	CDD:463574	12/50 (24%)
		DUF3694	<1215..1279	CDD:463599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1385..1404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1507..1531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1612..1645
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1749..1779