Protein Alignment Klp3A and kif21b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_073772347.1
• Gene: kif21b / 570502
• ZFINID: ZDB-GENE-130530-537
• Length: 1669
• Species: Danio rerio
• Alignment Length: 1390
• Identity: 385/1390 - (27%)
• Similarity: 625/1390 - (44%)
• Gaps: 312/1390 - (22%)

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLF 65
            |::::...|.|:||:||.:..|...||.|... ...|.|||.:.:::::||::|||:|..|:.::
Zfish     1 MATQNDCSVKVSLRIRPQMAKEKIEGCHICTS-VTPGEPQVLLGKDKAFTYDFVFDLDAHQQQIY 64

  Fly    66 ETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFN-GVLDDHVGVIPRAVHDIFTAIAEMQS 129
            ..||...::....|||.|:.|||||||||||||||.|: .|.:|..|:||||||.:|..|.:.:.
Zfish    65 SACVHKLIEGCFEGYNATVFAYGQTGSGKTYTMGTGFDVSVSEDEQGIIPRAVHQLFQGIQKRRL 129

  Fly   130 EFR--------FAVTCSFVELYQEQFYDLFSSKTRD------KATVDIRE-VKNRIIMPGLTELV 179
            |.:        |.|:..|:|||.|:..|||.| |||      |:.:.|.| ....|...|:|..:
Zfish   130 EAQSADIPPPDFKVSAQFLELYNEEILDLFDS-TRDPEARGRKSNIKIHEDGSGGIYTTGVTSRL 193

  Fly   180 VTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKL---------------DGKQS 229
            |:|..::...|..|:..|..|:|.||..|||||||||:.|...::               ||..|
Zfish   194 VSSEDELLQCLKLGALSRTTASTQMNAQSSRSHAIFTIHLCQMRVCPQPQLVNGELNGVSDGSMS 258

  Fly   230 -----VTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYR 288
                 ..:::|:.||||||||..:|.|:|:|.:||::||.|||||||||:||| ..:.||::|||
Zfish   259 QSEYETLSAKFHFVDLAGSERLKRTGATGERAREGISINCGLLALGNVISALGDQSKRAGHVPYR 323

  Fly   289 QSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNML 353
            .|||||||||||||||.|:|||||||:|.:..|||:||:||:||..||||.:||.|..:.:::.|
Zfish   324 DSKLTRLLQDSLGGNSRTVMIACVSPSDRDFMETLNTLKYANRARNIKNKVIVNQDKTSQQISAL 388

  Fly   354 KDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRK 418
            :..|.:|::|::. .|....:....|:.|...:..|.|:. ...|.....|:|....|:...|.:
Zfish   389 RAEIARLQMEIME-YKAGKRVACDEGSEGFSDLFQENSML-QRENDTLRMRVKAMQETIDHLNTR 451

  Fly   419 LQQ--------------ELHQSLLDLTE------KEMRAHI--AEQAHDKLRSHVSELKN----- 456
            :.|              |.::.:.:|.:      :|:|:.:  :|..::.||..:|.|.:
Zfish   452 VTQLLTNGVNLLLTKTGETNEEIGNLIQNYIREIEELRSKLLESEAMNESLRRSLSRLSSRSVYP 516

  Fly   457 ----------------------------KLD-------QREQAQFGNENTNGDNEMRDFSLLVNR 486
                                        |||       :|.|.:...|...|..:..       :
Zfish   517 SSHPSAPSIGSSPSVSMEAEMTDVIRQAKLDVERLKKKERNQRRKRPEKEKGLKKRA-------K 574

  Fly   487 VHVE---------LQRTQEELESQG---------HESRQRLSSRSHTEGGESGGDEVHEMLHSHS 533
            :|.|         |.|..||....|         .:....|....|   ||||.||..|......
Zfish   575 LHPEESGEKSENGLNRANEERRENGDGDSDNEPEEDGMYPLQEDDH---GESGCDEEEEEEEETR 636

  Fly   534 EEY--------------TNKQMNFAGELRNINRQLDLKQELHERI---MRNFSRLDSDDEDVKLR 581
            ||.              |::::|...:|.::..::::||.|.:.:   .|....|.|..|: ||.
Zfish   637 EEEEFDSDESLVDSDSDTDEKVNLQADLADLTCEIEIKQRLIDELENSQRRLLTLKSQYEE-KLI 700

  Fly   582 LCNQKIDDLEAERRDLMDQLRNIK--SKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKI 644
            |...||.|.:.||..::..|.:::  :::.::|:..|..|||:.:.:::..|:......|.|||.
Zfish   701 LLQNKIRDTQLERDRVLHNLMSMENYTEEKASKVKSEYEKRLKEMNRDLLKLQAAQKEHARLLKN 765

  Fly   645 RDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQ 709
            :.:...:::.|.:|:..||::||.|::.|:.|.::.|.....|.:|:.|||.:.|:.:.:|   :
Zfish   766 QGRYERELKKLQSEVAEMKKAKVALMKQMKEEQQRRRMIDAKRNREIAQLKKEQRRQEYQI---R 827

  Fly   710 TLHSKQRQ---VLKRKCEEALAANKRLKDALER-------------------------------- 739
            .|.|::||   ||:||.:|..|..:..|...||
Zfish   828 ALESQKRQQELVLRRKTQEVTALRRLAKPLSERAAGRVSRRLTSVDSGAELSTSTTTTTSSEPES 892

  Fly   740 ---------------------------QASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEI 777
                                       .|:..:.|.|::..|.|:..|..|..|..|...|.::|
Zfish   893 SRSVSSIIRHWNTKLNGYLGETDSHAPAANMASSRKKFQRKGPSSGFSKTARQKWQSLERRIMDI 957

  Fly   778 I---LSLIDAEHSLEQLMEDRAVINNHYHLL--QQEK-TSDPAEAAEQARILASLEEELEMRNAQ 836
            :   :::.:.|..:::|::.|..::.....|  ::|| .|:.....::.|:|..:.||:|:.||.
Zfish   958 VMQRMTITNVEADMDRLIKKREELSVQQEALLRKREKLLSESFREEDEERLLQEMNEEIEVLNAN 1022

  Fly   837 I-------SDLQQKV-----CPTDLDSRIRSLAEGVQSLGESRTVSKQLLKT------LVQQRRL 883
            |       ||.|..:     ...:|||...|:.....||.|:|::....||.      .|.|:..
Zfish  1023 IDYISDSLSDCQATIVQIEETKDELDSVDTSVVISSCSLAEARSLLDYFLKASIDKGLQVAQKEA 1087

  Fly   884 QASSLNEQRTTLDELRA----QLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAY---EEKVSVL 941
            |...|..|....|.:.:    .:|||.:::......|:.|  .|..|   |:..|   :|:||..
Zfish  1088 QIRLLEGQLRQTDVIGSSHNHMILDALREKAECIPELQAL--IHNVQ---QENGYASTDEEVSEF 1147

  Fly   942 IRTANQRWAEAR-SPAEDQQRNQILEELLSSREALQQE-----LDKLRAKNKSKSKAVKSEPQD- 999
            .:.:...:::.: |.::|..:.::...|.:..:|:..|     || |.:||.:||.|..||.|:
Zfish  1148 SQASESGFSQMKLSASQDDFKMKVEPRLSAQMKAVSAEYLGPILD-LNSKNITKSLASLSEIQEN 1211

  Fly  1000 ---LDDSF--QIVDGNETVVL-------------SDVSD--------------DPD--WVPSTSK 1030
               |.|::  ::|  :.|:.|             ||.|.              .||  :.|..|.
Zfish  1212 GLLLKDTYCRELV--SRTISLPIRGHTFPRQSRGSDASPLTRRQSYDRGQPYRSPDVGYTPPPSP 1274

  Fly  1031 SKRIQSDSRNVI----------SPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCK-GCKCRTKC 1084
            ..| |.:.|||.          |..:|.|.:.:||.......:..|...:.|:... .|....:.
Zfish  1275 PLR-QRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGVITPTGGLKGGRTAPLQCVAMAEG 1338

  Fly  1085 TTKRCGCLSGNNAC----SETCVCK 1105
            .||...||...:..    |:...||
Zfish  1339 HTKPVLCLDATDELLFTGSKDRTCK 1363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	164/365 (45%)
		Smc	<453..>985	CDD:440809	150/707 (21%)
		Metallothio	<1071..1115	CDD:395080	9/40 (23%)
kif21b	XP_073772347.1	None