Protein Alignment Klp3A and KIF15

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 1405
• Identity: 365/1405 - (25%)
• Similarity: 581/1405 - (41%)
• Gaps: 355/1405 - (25%)

  Fly     3 SEDPSCVAVALRVRPLVQSELDRGCRIAVER--SADGAPQVTVN-------------RNESYTYN 52
            |.:...:.|.:|:||            ..||  ||||...:.::             ..:::|::
Human    21 SNEGDAIKVFVRIRP------------PAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFD 73

  Fly    53 YVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHV-GVIPR 115
            :|.|:|.:|:.:|.|..::.|:..::|||.||.||||||||||:| ||.:.:.....:: |||||
Human    74 HVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPR 138

  Fly   116 AVHDIFTAIAEMQSEF----RFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGL 175
            :...:|:.|...:.:.    .|...|||:|:|.||.|||..|.:   |.:.:|| :|..:.:.|.
Human   139 SFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSAS---AGLYLREHIKKGVFVVGA 200

  Fly   176 TELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGK-QSVTTSRFNLVD 239
            .|.|||||.:....|..|...|.||:|:||..||||||:||:|:.:.:...: .::.||..||||
Human   201 VEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTSLLNLVD 265

  Fly   240 LAGSERCSKTLASGDRFKEGVNINKGLLALGNVINAL---GSGQAAGYIPYRQSKLTRLLQDSLG 301
            ||||||...|.|.|.|.||..|||:.|..||.||.||   |:|:.. ::.||.||||.||:||||
Human   266 LAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQR-HVCYRDSKLTFLLRDSLG 329

  Fly   302 GNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHA------AEVNMLKDVIQKL 360
            ||:.|.:||.|.|......||||||.:|.||..||||.|||.|...      |||..||:.:
Human   330 GNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQL--- 391

  Fly   361 RVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQ 425
             .||.||.....|.::............:|::.....:..|.:.|.|:|..|:|...|.::.:..
Human   392 -AELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQS 455

  Fly   426 S------------LLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQ-REQ-------AQFGNEN 470
            :            .|:...||.|.....:..|:|   :|||:|::.. |||       |::..||
Human   456 NKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRL---LSELRNEIQTLREQIEHHPRVAKYAMEN 517

  Fly   471 TNGDNEMRDFSLL--VNRVH-------VELQRTQEELE--SQGHESRQRLSSR--------SHTE 516
            .:...|.|...||  |.|..       .:|::...|:.  .:..:::|..|.:        ::||
Human   518 HSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTE 582

  Fly   517 GGESGGDEVHEMLHSHSEEY-------TNKQMNFAGELR-----NIN------------RQ---- 553
            ..::...::...|::..:||       ..:|:....||:     |:|            ||
Human   583 KLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQ 647

  Fly   554 --------LDLKQ-----------------------------ELHER---------------IMR 566
                    |.||.                             :||.|               ..:
Human   648 LNKIHAETLKLKNVMWIYNDLFNLENAGFFPIQIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQ 712

  Fly   567 NFSRLDSD--DEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEIS 629
            |.|.||:|  :|.|...:..|..:.:..|.|.:.:|:     ..:.|||.||..|.|: |:|.:.
Human   713 NSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQM-----SALQAKLDEEEHKNLK-LQQHVD 771

  Fly   630 DL---------------------RRKLITQANLLKIRDKEREKIQN----LSTEIRTM------- 662
            .|                     :.:|::|.|:|   :|:.::.|.    |.:|:..:
Human   772 KLEHHSTQMQELFSSERIDWTKQQEELLSQLNVL---EKQLQETQTKNDFLKSEVHDLRVVLHSA 833

  Fly   663 -KE-SKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEE 725
             || |.|||         ::..:|..:|||..:|..:...:|.::           ..|:.:.|:
Human   834 DKELSSVKL---------EYSSFKTNQEKEFNKLSERHMHVQLQL-----------DNLRLENEK 878

  Fly   726 ALAANKRLKDALER----------QASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILS 780
            .|.:...|:|:.:.          |.|...|..|          ..|...|:|      |..::.
Human   879 LLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFK----------KENETLKSD------LNNLME 927

  Fly   781 LIDAEHSLE-----QLMEDRAVINNHYHLL------QQEKTSDPAEAAEQARILASLEEELEMRN 834
            |::||....     |..||:.  |:...:|      :|||..:.|:..:|...:..|||.|....
Human   928 LLEAEKERNNKLSLQFEEDKE--NSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATE 990

  Fly   835 AQISDLQQ-----KVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTT 894
            ..||.|::     |....||.::|:.|...|....|:....||.||.:..:.........|.|..
Human   991 KVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVL 1055

  Fly   895 LDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAY-EEKVSVLIRTANQRWAEARSPAED 958
            :.:....:||.::     :.|||:|....|..||.:..|: .|::::|...:.:.....:|..|:
Human  1056 IKKQEVDILDLKE-----TLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEE 1115

  Fly   959 QQRNQILEELLSSREALQQELD-KLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDP 1022
                      |:.:|||.|||. ||..|        |.|.:...:.:.........|:...::||
Human  1116 ----------LTKKEALIQELQHKLNQK--------KEEVEQKKNEYNFKMRQLEHVMDSAAEDP 1162

  Fly  1023 DWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGC--KCRTKCT 1085
            . .|.|               ||..| .::..|..:..|.:      |||:..|..  ...||..
Human  1163 Q-SPKT---------------PPHFQ-THLAKLLETQEQEI------EDGRASKTSLEHLVTKLN 1204

  Fly  1086 TKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQC--------GDGDGQKDETEDADKSDDDG- 1141
            ..|    ...||  |....|...|...||:..:.|.        |..|..|.:.|::|::..|.
Human  1205 EDR----EVKNA--EILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQ 1263

  Fly  1142 ---DDEPQTSKENAVKFVTPEAPGKVVASPKQTLQEPKAA 1178
               :::.::.||...|....|...|:    |..|:|.::|
Human  1264 QLKNEQEESIKERLAKSKIVEEMLKM----KADLEEVQSA 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	141/354 (40%)
		Smc	<453..>985	CDD:440809	147/702 (21%)
		Metallothio	<1071..1115	CDD:395080	12/45 (27%)
KIF15	XP_016862373.1	KISc_KLP2_like	25..373	CDD:276824	148/363 (41%)
		SMC_N	<371..643	CDD:481474	55/278 (20%)
		SMC_prok_B	<579..1362	CDD:274008	171/824 (21%)