Protein Alignment Klp3A and kif1ab

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_009296795.1
• Gene: kif1ab / 566766
• ZFINID: ZDB-GENE-070912-480
• Length: 1799
• Species: Danio rerio
• Alignment Length: 1131
• Identity: 285/1131 - (25%)
• Similarity: 442/1131 - (39%)
• Gaps: 300/1131 - (26%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVN-----RNESYTYNYVF-------DIDDS- 60
            |.||:||||....|:.:..:..::.|  |.....:|     .|:|:.::|.:       |::.:
Zfish     6 VKVAVRVRPFNSREIGKDSKCIIQMS--GNTTTILNPKQPKENKSFNFDYSYWSHTTPEDVNYAC 68

  Fly    61 QKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAIA 125
            ||.::....:..:.....||||.|.||||||:||:|||   ......|..|:||....|:||.|.
Zfish    69 QKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTM---MGKQEKDQEGIIPLLCEDLFTKIN 130

  Fly   126 E-MQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTELVVTSAQQV 186
            : ..:...::|..|::|:|.|:..||.:.|  :|..:.:||  :.::.|   .|::|.|||...:
Zfish   131 DNNDNNMSYSVEVSYMEIYCERVRDLLNPK--NKGNLRVRE--HPLMGPYVEDLSKLAVTSYNDI 191

  Fly   187 TDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTT---SRFNLVDLAGSERCSK 248
            .|.:..|:..|.||||.||||||||||:|.:.....:.|.....||   |:.:|||||||||...
Zfish   192 QDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGSERADS 256

  Fly   249 TLASGDRFKEGVNINKGLLALGNVINALGSGQAA-----------GYIPYRQSKLTRLLQDSLGG 302
            |.|.|.|.|||.||||.|..||.||:||....:|           .:||||.|.||.||:::|||
Zfish   257 TGAKGTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWLLRENLGG 321

  Fly   303 NSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLR------ 361
            ||.|.|:|.:||||.|..||||||||||||.||:...|:|.||:...|..||:.:.:|:
Zfish   322 NSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEEVARLKDLLYAQ 386

  Fly   362 -----VELLSGGKMSSSLISAVGAAG---------LGAIPCEE-----SLAGSMANAAE------ 401
                 :|.||..|.:.|.|.||...|         .|..|...     |..||:::..:
Zfish   387 GLGDIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSISSLHDRIMFSP 451

  Fly   402 -----IQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQA-------------HDKLR 448
                 |:||||..:.:.:.|...:::|.::  :....|..|.:||..             ..|..
Zfish   452 GSEEAIERLKETEKIIAELNETWEEKLRRT--EAIRMEREALLAEMGVAMREDGGTVGVFSPKKT 514

  Fly   449 SHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLL-----VNRVHVELQRTQEELESQGHESRQR 508
            .|:                 .|.|.|..|.:..|.     :.:|..|...:::::...||..:..
Zfish   515 PHL-----------------VNLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDE 562

  Fly   509 LSSRSHTEGGESGGDEVHEMLHSHSEEYTN-KQMNFAGELRNINRQLDLKQELH-----ERIMRN 567
            ....:.|......|..|.|.... :|.|.| |::.....|::.||.:..|..:.     |:..::
Zfish   563 HCIFTSTTNAIGEGTVVLEPCEG-AETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQD 626

  Fly   568 FSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLR 632
            ..|....|..|      :.:|...|:|..|..|..::|         :|..:|||.||.:..
Zfish   627 RERTPCADTPV------EPVDWAFAQRELLEKQGIDMK---------QEMDQRLQELEDQYR--- 673

  Fly   633 RKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSK 697
                          ||||:..||..:.|...|||
Zfish   674 --------------KEREEASNLLEQQRLDYESK------------------------------- 693

  Fly   698 DRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSN 762
                         |.:.|:||..|...|.....:.|:|.:
Zfish   694 -------------LEALQKQVNSRYYPETTEEEEELEDEV------------------------- 720

  Fly   763 ANAKTDSWVDRELEIILSLIDAEH-----SLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARI 822
                  .|..||.|:.|.......     ||..|:...|:.                 ..|...|
Zfish   721 ------PWTKRETELALWAFRKWRFYQFTSLRDLLWGNAIF-----------------LKEANAI 762

  Fly   823 LASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASS 887
            ...|:::::.:...::|......|.||      |...:....|.|...:.::...||.::..|:
Zfish   763 SVELKKKVQFQFVLLTDTLYSPLPPDL------LPPSIAKDREKRLFPRTIVAVEVQDQKNGAT- 820

  Fly   888 LNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEA 952
               ...|||:||              :||.|::..::........|.|:...::         ..
Zfish   821 ---HYWTLDKLR--------------QRLDLMREMYDRAAEVPSTAVEDCDHIM---------SG 859

  Fly   953 RSPAEDQ-------QRNQILEELLSSREA----------LQQELDKLR-AKNKSKSKAVKSEPQD 999
            ..|..|:       .|..||...:|.|.:          ...::.:|. .::..|.:..:.|.:|
Zfish   860 GDPFYDRFPWFRLVGRTPILNTCMSERMSGLTLSPTLSDPDSDITELADERHYGKVEVEEEELED 924

  Fly  1000 LDDSFQIVDGNETVVLSDVSDDPDWV 1025
            |||...:.|....:...:..||.|.|
Zfish   925 LDDEIFVEDNGSELGREEEEDDDDGV 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	143/357 (40%)
		Smc	<453..>985	CDD:440809	95/565 (17%)
		Metallothio	<1071..1115	CDD:395080
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	145/363 (40%)
		Kinesin_assoc	358..538	CDD:465047	40/198 (20%)
		FHA	514..628	CDD:469597	23/131 (18%)
		ERM_helical	647..>702	CDD:466641	23/124 (19%)
		KIF1B	828..875	CDD:463574	9/69 (13%)
		DUF3694	1273..1428	CDD:463599
		PH_KIFIA_KIFIB	1680..1782	CDD:269939