Protein Alignment Klp3A and kif19

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_005156460.1
• Gene: kif19 / 565913
• ZFINID: ZDB-GENE-080215-2
• Length: 1015
• Species: Danio rerio
• Alignment Length: 1134
• Identity: 285/1134 - (25%)
• Similarity: 488/1134 - (43%)
• Gaps: 240/1134 - (21%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTV----------------NRNESYTYNYVFDI 57
            :.||||:|||..:||:.|..|...:..|   |:.|                :|.::|.::..||.
Zfish    12 LTVALRIRPLSDAELEEGATIIAHKVDD---QMVVLLDPMEDPDDILRAHRSREKTYMFDVAFDY 73

  Fly    58 DDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHVGVIPRAVHDIF 121
            ..:|.:::....:..::.|::|||.|:.|||.||.|||||| ||      |...|:..|.::|:|
Zfish    74 SATQDEVYRYTTKGLIEGLISGYNATVFAYGPTGCGKTYTMLGT------DREPGIYVRTLNDLF 132

  Fly   122 TAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQ 185
            .||.|...:.:::|:.|::|:|.|...||.:..:   ..:|:|| .|..|.:.|:||:...:|::
Zfish   133 KAIEETSDDMQYSVSMSYLEIYNEMIRDLLNPSS---GFLDLREDSKGEIQVAGITEVSTINARE 194

  Fly   186 VTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK----LDGKQSVTTSRFNLVDLAGSERC 246
            :.:.|::|:..|....||.|:|||||||:  |.:|..:    .|..|.|..:|..::|||||||.
Zfish   195 IMELLMKGNKQRTQEPTAANQTSSRSHAV--LQVVVRQQSRCRDILQEVRFARLFMIDLAGSERA 257

  Fly   247 SKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIAC 311
            |:|...|.|.|||.:||:.||||||.||||.......|:.||.|||||||:|||||||.|:|||.
Zfish   258 SQTQNRGQRLKEGAHINRSLLALGNCINALSEKNGNKYVNYRDSKLTRLLKDSLGGNSRTVMIAH 322

  Fly   312 VSPADYNVAETLSTLRYADRALQIK---NKPVVNLDPHAAE----VNMLKDVIQKLRVELLSGGK 369
            :|||.....::.:||.|||||..|:   .:.::|:..|.|:    ::.|:..||:|:.::   ..
Zfish   323 ISPASLAFEDSRNTLTYADRAKSIRTRVKRNLLNVSYHIAQYTSIISDLRSEIQRLKKKI---AD 384

  Fly   370 MSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKE 434
            .:|..|:. ....:..:..|.....|..:.||:.:|:||   |.|..|: |.::.:.|::|....
Zfish   385 QASRQINP-DRTDIRHVQAEVQAHSSQQSRAEMDQLREQ---LIDAFRQ-QMDIRKRLMELDNSN 444

  Fly   435 MRAHIAEQAH-----DKLRSHVSELKNKLDQREQAQFGNENTNGDN----------EMRDFSLLV 484
            |...|....|     |..:......|....:|.:..|..:.:..|:          |.::.::..
Zfish   445 MEIQIDTSKHLLTIADWEQERFRRRKKWQGERRKESFNKDESEKDSDSPESLPDSTETQEVAIAR 509

  Fly   485 NRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRN 549
            ..: |.|...|::::.|.....|||:                                   |||.
Zfish   510 ENL-VTLMAEQKKIQKQKAGLEQRLA-----------------------------------ELRE 538

  Fly   550 INRQLDLKQELHERIMRNFSRLDSDDE-DVKLRLCNQKIDDLEAERRDLMDQ--LRN--IKSKDI 609
            ..|:|   :||..|      |:.|::: :|...||  |:.:||.|..::...  |::  |:.|::
Zfish   539 KARRL---EELLPR------RVSSEEQREVLCLLC--KVHELEIENAEMQSSALLKDNVIRQKNV 592

  Fly   610 SAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNL-STEIRTMKESKVKLIRAM 673
            ..:..|:.|.    |..||...:|:.|...:||     ....:|.| ...::.|.|..:..:.|:
Zfish   593 VVQRFEQHRH----LCHEIIQQQRQFIDDHSLL-----VPPHLQELYEMYMKEMDEKNLDRVVAL 648

  Fly   674 RGESEKF--RQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDA 736
                :||  |..|:..|..|.::               ||.|:.|..|:....:..:......|
Zfish   649 ----DKFTIRTLKVHHEGSLPKI---------------TLPSRGRDPLQELDSDQESVRTLASD- 693

  Fly   737 LERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEH---SLEQLMEDRAVI 798
             .||...:.:||                         .|..||...|.|.   |..:.|::..|:
Zfish   694 -NRQGRTKLRRH-------------------------TLPPILPEPDGERVFKSSHKQMKNTVVM 732

  Fly   799 NNHYHLLQQEKTSDPAEAAEQA--RILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQ 861
                       |..|.....|.  .:|.|:.:| .:|.:.:|.        .:.|.:.|..|..:
Zfish   733 -----------TPPPIHINGQGNRELLPSVLDE-ALRCSHLSH--------SMSSHLDSSPESSE 777

  Fly   862 SLGESRTVSKQLLKTL--VQQRRLQASSLNEQRTTLDELR----AQLLDAQQQEDAASKRLRLLQ 920
            :..::....|:..:.|  ||...::|:....:...:|.||    ...||.::.:    ..|.|.:
Zfish   778 NGTDAPLTPKERQQILRGVQNIAVKAARRRSKVLEIDALRLPPPPSPLDPKKHK----SNLSLSE 838

  Fly   921 SQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAED----QQRNQILEELLSSREALQQELDK 981
            :..:..:|.:.|....::.......|...:....||.:    :.||:........||   |:.:.
Zfish   839 APPKGPVLRRGRQPSPELRHATSDDNLSSSTGDGPAPNGTWTRPRNRQAVRNAGPRE---QDFEG 900

  Fly   982 LRAKNKSKSKAVK----SEPQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVI 1042
            .|.|.:|:|..|.    |:.::.:..|:.:|......| .::..|   |:.            ::
Zfish   901 RRRKRRSRSFEVTGQALSQAKNTNQRFRPLDSTSDPHL-HINGHP---PAP------------LL 949

  Fly  1043 SPPEKQDANVTSLGNSSIQSLNSTSATED 1071
            .|..:..|.:|....|  .:::.|.:|.|
Zfish   950 RPQHRAQAQLTKARPS--HNIHQTGSTAD 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	137/348 (39%)
		Smc	<453..>985	CDD:440809	104/564 (18%)
		Metallothio	<1071..1115	CDD:395080	1/1 (100%)
kif19	XP_005156460.1	KISc_KIP3_like	11..346	CDD:276821	137/347 (39%)
		EnvC	340..>558	CDD:443969	53/270 (20%)