Protein Alignment Klp3A and kif14

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_005170522.2
• Gene: kif14 / 562052
• ZFINID: ZDB-GENE-030131-5759
• Length: 1506
• Species: Danio rerio
• Alignment Length: 1354
• Identity: 336/1354 - (24%)
• Similarity: 545/1354 - (40%)
• Gaps: 362/1354 - (26%)

  Fly     7 SCVAVALRVRPLVQSEL-DRGCRIAVERSADGAPQVTVNRNESYTYNYVFDID-----------D 59
            |.|.||:||||....|. ::.|::....:.|...|   :.:...|:.:.||..           .
Zfish   234 SAVTVAVRVRPFSSREKNEKACQVIFMENQDTLVQ---HPDTKQTHKFTFDFSFCSINEADASFS 295

  Fly    60 SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAI 124
            ||:.::|...:..:::..:|:|..:.|||||||||:||| ..|.    :..|||||...::|:.:
Zfish   296 SQQLIYEKLARPLLERAFDGFNTCLFAYGQTGSGKSYTM-MGFG----EETGVIPRFCEELFSRL 355

  Fly   125 AEMQS-EFRFAVTCSFVELYQEQFYDLFSSK---TRDKATVDIREVKNRIIMPGLTEL---VVTS 182
            |..:: |....:..|:.|:|.|:.:||..:|   .:.|..:.:||  :.:..|.:.:|   ||:|
Zfish   356 ARSETKEMSCHLEMSYFEVYNEKIHDLLVAKDEQNQKKMPLRVRE--HPVYGPYVADLSTNVVSS 418

  Fly   183 AQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQS-----VTTSRFNLVDLAG 242
            ...:...|..|:..||.|||.||:.|||||::|||.:..||.:..:.     ..|||.|||||||
Zfish   419 YSDIKTWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEEEEHDHCITSRINLVDLAG 483

  Fly   243 SERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAG----YIPYRQSKLTRLLQDSLGGN 303
            ||||:....||||.:||.:|||.||.||.||::| |.|:..    :.|||:|.||.||::|||||
Zfish   484 SERCTSAQTSGDRLREGASINKSLLTLGKVISSL-SEQSQSRKKVFTPYRESVLTWLLKESLGGN 547

  Fly   304 SITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS-- 366
            |.|.|||.:|||..|:.|:|||||||.:|..|.|...||.|.:|..:..||..::|||...:|
Zfish   548 SKTAMIATLSPAASNMEESLSTLRYAQQARMIINIAKVNEDTNAKLIRDLKAEVEKLRAAQMSSQ 612

  Fly   367 GGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRL-KEQVRTLQDRNRKLQQELHQ----- 425
            |.:.....:.....|.|....|::.     ...||..|. ||::...:.|.|:..:||.:
Zfish   613 GVEPEKMRLFQQEIAALKNKLCQQE-----HEMAEAHRTWKEKLEEAERRKREEAKELQRAGVTF 672

  Fly   426 -------SLLDLTE------------KEMRAHI----AEQAHDKLRS-------H--VSELKN-- 456
                   :|::|.|            ||.:..:    :|.|||...|       |  :|.:|.
Zfish   673 KVDNRLPNLVNLNEDPQLSEMLLYMIKEGQTKVGKLKSESAHDIQLSGALIADQHCVISSVKGTV 737

  Fly   457 -------------------------------------KLDQREQAQFGNEN---TNGDNEMRDFS 481
                                                 :.:...:.|.|...   ::||.. :||.
Zfish   738 SIKPMPNAKTFVNGHLVSECTVLHHGDRVILGGDHYFRFNHPAEVQSGKRASCWSSGDGH-KDFE 801

  Fly   482 LLVNRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGE 546
            ...|.: :..||.|.|.|.|    ..||.::.....|.....|:.:      :|.:.::..:..:
Zfish   802 FAKNEL-LSAQRAQLEAEIQ----EARLKAKEEMMQGIQVAKEMAQ------KELSEQKSLYEIK 855

  Fly   547 LRNINRQL------DLKQELH--------ERIMRNFSRLDSDDEDVKLRL------CNQKIDD-- 589
            :|.:.|:|      ..:||||        |::....:.|:.:....|.||      ..|.:.|
Zfish   856 IRALERELKEESERKREQELHKQRAASQIEQLQSVKTLLEKEVSSHKRRLQMEAQATRQAMADHD 920

  Fly   590 ---------LEAERRDLMDQLRNIKSKDI-----SAKLA--EERRKRLQLLEQEISDLRRKL--I 636
                     ||||:|.:.:.|..|:.|..     :.|:|  :....:|.|:.:|.:.:..||  .
Zfish   921 VRHAKIVAALEAEKRKIAEDLAQIEMKRALKVTQTPKMAIPQWDAMKLSLMIEEANKISGKLRKH 985

  Fly   637 TQANLLKIRDKERE--------KIQNLSTEIRTM--KESKVKLIRAMR----GES---------E 678
            |..:..:..|||.|        ::||....|.|.  .|.....:.|||    |||         :
Zfish   986 TVFSRHEAADKEVEGGDAQLQVQVQNTKLGISTFWSLEKFQSNLAAMREIEQGESASKDDDVFYD 1050

  Fly   679 KFRQWK-----------MVREKELTQLKSK---DRKMQSEIVRQQTLHSKQRQVLKRKCEEALAA 729
            ...:|:           ..|.:..:.|||:   .|..:..:...|:||....|       .....
Zfish  1051 PNDEWEPDLSASSSTSSFSRRRSRSLLKSRRISGRLYEIRVHPIQSLHCTPSQ-------STGLM 1108

  Fly   730 NKRLKDALERQASAQAQRHKYKDNGGSAAG---SSNANAKTDSWVDRELEIILSLIDAEHSLEQL 791
            ||  ..:|....|..|.....||..|||..   |..:..:::|..|:....:||:..|..|:..|
Zfish  1109 NK--PPSLHSSTSDSALPGICKDLIGSAVARLRSCQSADESESLADKLTLDLLSVHRAVRSITDL 1171

  Fly   792 MED----------RAVINNHYHLLQQEKTSDPAEAAEQARIL---------------ASLEEELE 831
            .||          ........||::      ...|.|:|..:               :...|||:
Zfish  1172 YEDLDDDSEENLFACSTEAQTHLVK------ATSAVERAVFITMHWVSSITFGSITVSQRAEELK 1230

  Fly   832 MRNAQISDLQQKV---CPTDLDSRI----RSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLN 889
            |...:|....|.:   |.:::.|.:    :.:||.:.:          :.||:.....:..:.|:
Zfish  1231 MEVKKIGGYLQLLIQGCDSEISSMVTEARKRVAECINA----------VFKTIGFLAAVNGTDLH 1285

  Fly   890 EQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTAN----QRWA 950
                 |:|..::.:|.:...|.....:|    |..:.:|:......|::..:..|.:    .:|.
Zfish  1286 -----LNEQNSETIDNRSVVDCLQDGMR----QSVKDLLSVGLLVTEEMLQVSHTGSTLQISKWM 1341

  Fly   951 E-AR----------SPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSF 1004
            : ||          |.:.|...|..::...|:...:|....||...|    :|:|    ||..|.
Zfish  1342 DVARSLQNYLRCCLSKSSDSSENHCVDYESSNLYDIQSTTTKLLKLN----QAIK----DLHSSL 1398

  Fly  1005 -QIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGN----------- 1057
             :.:.|..:              .||.|:.|||.|:.:       |..::||.:
Zfish  1399 SRFLKGRRS--------------DTSLSEAIQSSSQTI-------DKIISSLPHEITGHSDGLQL 1442

  Fly  1058 -----SSIQSL-----NSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSET 1101
                 |::|:|     |||...:            |.||.|....||.::.:.|
Zfish  1443 QDDVQSALQALLAVFSNSTDEIQ------------KPTTDRHFVQSGYSSRNRT 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	138/356 (39%)
		Smc	<453..>985	CDD:440809	131/700 (19%)
		Metallothio	<1071..1115	CDD:395080	7/31 (23%)
kif14	XP_005170522.2	None