DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and KIF21A

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001365368.1	Gene:	KIF21A / 55605	HGNCID:	19349	Length:	1675	Species:	Homo sapiens

Alignment Length:	1357	Identity:	362/1357 - (26%)
Similarity:	607/1357 - (44%)	Gaps:	305/1357 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLF 65
            :.:.|.|.|.||:|:||.:..|...||.|... ...|.|||.:.:::::|::||||||..|:.::
Human     2 LGAPDESSVRVAVRIRPQLAKEKIEGCHICTS-VTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIY 65

  Fly    66 ETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFN-GVLDDHVGVIPRAVHDIFTAIAEMQ- 128
            ..|::..::....|||.|:.||||||:||||||||.|: .::::.:|:|.|||..:|.:|.|.:
Human    66 IQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKH 130

  Fly   129 ---------SEFRFAVTCSFVELYQEQFYDLFSSKTRD------KATVDIRE-VKNRIIMPGLTE 177
                     .:|:  |...|:|||.|:..|||.: |||      |:.:.|.| ....|...|:|.
Human   131 IAIKNGLPAPDFK--VNAQFLELYNEEVLDLFDT-TRDIDAKSKKSNIRIHEDSTGGIYTVGVTT 192

  Fly   178 LVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTL----TLVATKLDGKQS--------- 229
            ..|.:..::...|..|:..|..|:|.||..|||||||||:    |.|..::|...:
Human   193 RTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISES 257

  Fly   230 -------VTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIP 286
                   ..|::|:.||||||||..:|.|:|:|.|||::||.|||||||||:||| ..:.|.::|
Human   258 AQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVP 322

  Fly   287 YRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVN 351
            ||.|||||||||||||||.|:|||||||:|.:..|||:||:||:||..||||.:||.|..:.::|
Human   323 YRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQIN 387

  Fly   352 MLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMAN--AAEIQRLKEQVRTLQD 414
            .|:..|.:|::||:. .|....:|...|...:..:..|.::..:..|  ...|:.::|.|..|:.
Human   388 ALRSEITRLQMELME-YKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRS 451

  Fly   415 R-------------------NRKLQQELHQSLLDLTEKEMRAHI--AEQAHDKLRSHVS------ 452
            |                   |.::...:|..:.::  :::||.:  :|..::.||.:::
Human   452 RITQLVSDQANHVLARAGEGNEEISNMIHSYIKEI--EDLRAKLLESEAVNENLRKNLTRATARA 514

  Fly   453 --------------------------------ELKNK-------------LDQREQAQFGNE-NT 471
                                            :||.|             .::.|::..|.| ||
Human   515 PYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREERSVAGKEDNT 579

  Fly   472 NGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRSH--TEGGESGGDEVHEMLHSHSE 534
            :.|.|.::...:..|.:.||: .:|..|...||..:.......  .:|||| .||        |:
Human   580 DTDQEKKEEKGVSERENNELE-VEESQEVSDHEDEEEEEEEEEDDIDGGES-SDE--------SD 634

  Fly   535 EYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDS--DDEDVKLRLCNQKIDDLEAERRDL 597
            ..::::.|:..:|.||..::.:||:|.:.:..:..||.:  ...:.||.:...||.|.:.||..:
Human   635 SESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQV 699

  Fly   598 MDQLRNIK--SKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIR 660
            :..|.:::  |::.:.|:..|..|:||.:.:|:..|:......|.|||.:.:..::::.|..::.
Human   700 LQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVM 764

  Fly   661 TMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEE 725
            .||::||:|::.|:.|.||.|..:..|.:|:.|||...||...::...:.....|..||:||.||
Human   765 EMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEE 829

  Fly   726 ALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDS--------------------- 769
            ..|..::::...::.|....::....|......|||.|..:||:
Human   830 VTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPT 894

  Fly   770 ----------------------------W--VDREL-EII---LSLIDAEHSLEQLMEDRAVINN 800
                                        |  ::|.: :||   :::.:.|..:.:|::.|..:..
Human   895 PATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTK 959

  Fly   801 HYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGE 865
            ....|.:.:.....|..|..:.:|::.||:|...|.|..:...:  :|..:.|..:.|..:. ||
Human   960 RREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSI--SDCQANIMQMEEAKEE-GE 1021

  Fly   866 SRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQ 930
            :..|      |.|    :.|.:|.|.|..||...:.         ..:|.|:..|.:.:.::|..
Human  1022 TLDV------TAV----INACTLTEARYLLDHFLSM---------GINKGLQAAQKEAQIKVLEG 1067

  Fly   931 QRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKS 995
            :....|     |.:|.|              ||:|..:|..:..|..|||.|          :..
Human  1068 RLKQTE-----ITSATQ--------------NQLLFHMLKEKAELNPELDAL----------LGH 1103

  Fly   996 EPQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSI 1060
            ..||||          :|.|.:|.|..|                        :||.:.|.|
Human  1104 ALQDLD----------SVPLENVEDSTD------------------------EDAPLNSPG---- 1130

  Fly  1061 QSLNSTSATEDGKRCKGCKCRTKC---TTKRCGCLSGNNA--CSETCVCKSNCRNPLNLKDHASQ 1120
             |..||.:::..|.|...|.:.|.   ||.:...|..:::  .|:|....::...||      :.
Human  1131 -SEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPL------TP 1188

  Fly  1121 CGDGDGQKDETEDADKSDDDGDDEPQTSKENAVKFVTPEAPGKVVASPKQ-TLQEPK 1176
            ..:|......||.:..|..:.:..|           .|..|.|:.:..:| :|.|.|
Human  1189 VAEGQEIGMNTETSGTSAREKELSP-----------PPGLPSKIGSISRQSSLSEKK 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	158/367 (43%)
		Kinesin	14..335	CDD:278646	154/359 (43%)
		Smc	<396..>994	CDD:224117	147/733 (20%)
		FlaC	522..633	CDD:225888	28/114 (25%)
		TCR	1075..1110	CDD:281618	8/39 (21%)
KIF21A	NP_001365368.1	KISc_KIF4	8..372	CDD:276823	158/367 (43%)
		Cast	<364..836	CDD:401982	113/484 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..641		21/94 (22%)
		Smc	<644..1004	CDD:224117	78/361 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..804		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..881		8/39 (21%)
		Rcc_KIF21A	936..1017	CDD:410204	15/82 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1138		10/50 (20%)
		Interaction with KANK1 and KANK2. /evidence=ECO:0000269\|PubMed:29183992	1146..1167		5/20 (25%)
		WD40	1340..1653	CDD:238121
		WD 1	1346..1383
		WD 2	1386..1424
		WD40 repeat	1391..1450	CDD:293791
		WD 3	1450..1488
		WD40 repeat	1456..1491	CDD:293791
		WD 4	1491..1533
		WD40 repeat	1496..1540	CDD:293791
		WD 5	1542..1579
		WD40 repeat	1548..1581	CDD:293791
		WD 6	1583..1622
		WD40 repeat	1588..1624	CDD:293791
		WD 7	1625..1662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720