Protein Alignment Klp3A and KIF27

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_011517150.1
• Gene: KIF27 / 55582
• HGNCID: 18632
• Length: 1427
• Species: Homo sapiens
• Alignment Length: 1497
• Identity: 371/1497 - (24%)
• Similarity: 604/1497 - (40%)
• Gaps: 444/1497 - (29%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            |.||:|:|||:..|.....::.| |....:.||.:.|:..:|:::||..:.:|.:::.||::..|
Human     6 VKVAVRIRPLLCKEALHNHQVCV-RVIPNSQQVIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLV 69

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTA-FNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRFAVTC 137
            ..|:.|||.|:.||||||||||||:|.. ...|::...|:||||:.:||.:|:|..| ..|.|..
Human    70 LSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQSISEHPS-IDFNVKV 133

  Fly   138 SFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAA 201
            |::|:|:|...||...:|..| .:.||| .|...::.|..|..|.||.:|...|..|:|.|....
Human   134 SYIEVYKEDLRDLLELETSMK-DLHIREDEKGNTVIVGAKECHVESAGEVMSLLEMGNAARHTGT 197

  Fly   202 TAMNETSSRSHAIFTLTL--VATKLDGKQSVT-------TSRFNLVDLAGSERCSKTLASGDRFK 257
            |.|||.|||||||||:::  |...::..:..:       .|:|:.||||||||.:||..:|:|||
Human   198 TQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKFHFVDLAGSERVTKTGNTGERFK 262

  Fly   258 EGVNINKGLLALGNVINALGS-GQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAE 321
            |.:.||.|||||||||:|||. .:.:.:||||.:|:||||:|||||::.|:||.||||:..|..|
Human   263 ESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSNFDE 327

  Fly   322 TLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS--GGKMSSSLISAVGAAGLG 384
            :|::|:||:||..|:|||.||..|.:..::.::..|:.||..|.|  .|...::.|:..|:....
Human   328 SLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINREGSPDTN 392

  Fly   385 AI-PCEESLAGSMANAAEIQ-----------RLKEQVRTLQDRNRKLQ------QEL-------- 423
            .| ..||.:|.........|           .||:.||..:.:..|||      ||:
Human   393 RIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNMIQEVRKAVLTSF 457

  Fly   424 --------------HQSLLDLTE--KEMRAHIA--EQAHDKLRSHVSELKNKLDQREQAQFGNE- 469
                          |.::|.|..  |:.:..:|  |...::....|.||||::....|...|:.
Human   458 RGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQENKGHAV 522

  Fly   470 ---------------------------------NTNGDNE-MRDFSLLVNRVHVELQRTQEELES 500
                                             |.|..|| :.:..|||:::..||.:....:.|
Human   523 SLKEAQKVNRLQPLAKTTLLSTSMDLPILNISYNWNHTNEKIIEQQLLVDQLSEELTKLNLSVTS 587

  Fly   501 QGHE-------------------------------SRQRLSSRSHT------------------- 515
            ...|                               |||. |.:.||
Human   588 SAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQD-SRKVHTSPPMYSLDRIFAGFRTRSQ 651

  Fly   516 --------------------------EGGESGG------------DEVHEMLH-SHSEEYTNK-- 539
                                      ||.|..|            |.|..::. |.:::.|.|
Human   652 MLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSD 716

  Fly   540 ---------------QMNFAGELRNINRQL-DLKQELHE-----------------------RIM 565
                           ::|.. :|:|..|.| :.||::.|                       .:.
Human   717 LENEDLKIDCLQESQELNLQ-KLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVS 780

  Fly   566 RNFS----RLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDIS-----AKLAEERRKRL 621
            :.:|    :|:.|.|..|:.|       :|.::     ||:.:::||:|     .||.:|.||::
Human   781 KQYSLKVTKLEHDAEQAKVEL-------IETQK-----QLQELENKDLSDVAMKVKLQKEFRKKM 833

  Fly   622 QLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMV 686
            ...:..:..|::|......|..:..:..::...|...:..||..|::|.|.:|.|:||
Human   834 DAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREENEK------- 891

  Fly   687 REKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAAN-KRLKDALERQASAQAQRHKY 750
             .|:|..:..:|::...||    .|.:.|.:.||.|.|:..|.| ||.|.:.
Human   892 -RKQLDAVIKRDQQKIKEI----QLKTGQEEGLKPKAEDLDACNLKRRKGSF------------- 938

  Fly   751 KDNGGSAAGSSNANAKTD---SWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKT-- 810
                    ||.:...|.|   .|:|.|:|.:|:.......||..::.|..|.:....|.|||:
Human   939 --------GSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHL 995

  Fly   811 ------SDPAEAAEQARI---LASLEEELEMRNAQI--SDLQQKVCPTD---------------- 848
                  |..|...:..:|   |..||:||..:|.|:  |..::|...::
Human   996 ENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQVEVLQKEKDQLQKRR 1060

  Fly   849 --LDSRIRS--------------LAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLN-------- 889
              :|.::::              |.||:::|..:.....:.::.  :|:.|:||..|
Human  1061 HNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQN--RQKSLRASFHNLSRGEANV 1123

  Fly   890 ----------EQRTTL---------------------DELRAQLLDAQQQEDAASKRLRLLQSQH 923
                      |.||.|                     :|::.::|:...........|..|:.|.
Human  1124 LEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQC 1188

  Fly   924 EEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQ-ELD-----KL 982
            :.::..||:.:|:|:.:|:.           ..::|....|:|...:..:.:|| |.|     |.
Human  1189 DRRLTLQQKEHEQKMQLLLH-----------HFKEQDGEGIMETFKTYEDKIQQLEKDLYFYKKT 1242

  Fly   983 RAKNKSKSK-----AVK-----SEPQDLDDSFQIVDGN-------------ETVVLSDVSDDPDW 1024
            ...:|.|.|     |::     ||.|:..|.....:|.             |::.||....:.|
Human  1243 SRDHKKKLKELVGEAIRRQLAPSEYQEAGDGVLKPEGGGMLSEELKWASRPESMKLSGREREMD- 1306

  Fly  1025 VPSTSKSKRIQSDSRNV-------------ISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCK 1076
              |::.|.|.|.:.:.:             ::||...     .|||.     |.|. |:|.:..|
Human  1307 --SSASSLRTQPNPQKLWEDIPELPPIHSSLAPPSGH-----MLGNE-----NKTE-TDDNQFTK 1358

  Fly  1077 GCKCRTKCTTKRCGCLSGNNACSETCVCKSNCR--NPLNLKDHASQCGDGDGQ--KDETEDADKS 1137
            . ..|.....:..|.:...:..:...:|:...|  :.|.|....|..|.|.|.  .|..|.:.|.
Human  1359 S-HSRLSSQIQVVGNVGRLHGVTPVKLCRKELRQISALELSLRRSSLGVGIGSMAADSIEVSRKP 1422

  Fly  1138 DD 1139
            .|
Human  1423 RD 1424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	147/338 (43%)
		Smc	<453..>985	CDD:440809	147/799 (18%)
		Metallothio	<1071..1115	CDD:395080	7/45 (16%)
KIF27	XP_011517150.1	KISc_KIF4	4..342	CDD:276823	147/338 (43%)
		PTZ00121	<658..1227	CDD:173412	119/627 (19%)