Protein Alignment Klp3A and kif3cb

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001017849.2
• Gene: kif3cb / 550547
• ZFINID: ZDB-GENE-080709-4
• Length: 759
• Species: Danio rerio
• Alignment Length: 800
• Identity: 234/800 - (29%)
• Similarity: 363/800 - (45%)
• Gaps: 208/800 - (26%)

  Fly     9 VAVALRVRPLVQSE----LDRGCRIAVERSADGAPQVTVNRN--------ESYTYNYVFDIDDSQ 61
            |.|.:|.|||.:.|    .:|...:.|...     ||:| ||        :|:|::.|:|:...|
Zfish    22 VKVVVRCRPLNKKEEAMNQERIVEVDVRLG-----QVSV-RNPKSSGSLVKSFTFDAVYDVSSKQ 80

  Fly    62 KDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHV--GVIPRAVHDIFTAI 124
            .:|::...:..:..:|.|:|.||.||||||:||||||    .||..|..  ||||.:...|||.|
Zfish    81 NELYDYACKPLIDSVLLGFNGTIFAYGQTGTGKTYTM----EGVPTDPETRGVIPNSFQHIFTQI 141

  Fly   125 AEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVTDH 189
            :..|:: ::.|..|::|:|||:..||.......|  ::::|.....:.......|||...:..:|
Zfish   142 SRSQNQ-QYLVRVSYIEIYQEEIRDLLCKDNNKK--LELKENPELGVYVKDLSCVVTKNIKEIEH 203

  Fly   190 LIR-GSAGRAVAATAMNETSSRSHAIFTLTLVATK--LDGKQSVTTSRFNLVDLAGSERCSKTLA 251
            ::. |:..|:|..|.|||.||||||||.:|:..::  :||:..:...:.|:||||||||.|||..
Zfish   204 VMNLGNQSRSVGFTKMNERSSRSHAIFVITIECSEMGIDGEDHIRVGKLNMVDLAGSERQSKTGV 268

  Fly   252 SGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPAD 316
            .|.||||...||..|.||||||:||..|::. ::|||.||||||||||||||:.|:|:|.|.||.
Zfish   269 QGRRFKEAAKINLSLSALGNVISALVDGKST-HVPYRDSKLTRLLQDSLGGNAKTVMVATVGPAS 332

  Fly   317 YNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGG------------- 368
            ....|||:|||||:||..|||||.:|.||..|.:...::.|.:|:.:|...|
Zfish   333 CYYDETLTTLRYANRAKNIKNKPKINEDPKDALLREFQEEIARLKAQLEERGMLAKERRRQKRNS 397

  Fly   369 -KMSSSLISA-VGAAGLGAIPC-----EES---------LAGSMAN-----AAEIQRLKEQVRTL 412
             :|..|:.|. |....:|.:..     |||         :|.:.||     :.::..:.|:|:|:
Zfish   398 LRMKRSMSSGEVETPRIGEVEVVETVREESVEDYWWKQQMAKTSANYKPDISRKLGMVNEKVKTV 462

  Fly   413 QDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSEL----KNKLDQREQAQFGNENTNG 473
            ::            ||    ||.:|  .|...:|.::..|:|    ||.:|          :||.
Zfish   463 EE------------LL----KEQQA--MENMIEKYKAMESKLLVGGKNIID----------HTNE 499

  Fly   474 DNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTN 538
            ..:|             |:.|:.|:..|..:.|                 |:.:::....||
Zfish   500 QQKM-------------LELTRLEIAEQDRKER-----------------EMQQLMFEQDEE--- 531

  Fly   539 KQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDE--DVKLRLCNQKIDDLEAERRDLMDQL 601
                          .::||:        .||.|..:.|  ..|||....|:..:.:|..|::::.
Zfish   532 --------------TIELKE--------TFSTLQQEVEFKTKKLRKFYSKLQLVRSEIGDIINEH 574

  Fly   602 RNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESK 666
            ..::                |.|||.:::|.|::               |.:||..|.....|.|
Zfish   575 VTMR----------------QELEQTMNELTREM---------------KFKNLIIENFIPPEEK 608

  Fly   667 VKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANK 731
            .|:|..:..:||: .|||::                      ..|.|:....|.|:...::..||
Zfish   609 NKIINRLHFDSEE-DQWKVL----------------------PLLPSENNSPLVRRRPTSVVGNK 650

  Fly   732 RLKDALERQASAQAQRHKYK 751
            |......:.|.|.....:|:
Zfish   651 RPVSMYAQTAVAHGSPSRYR 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	143/343 (42%)
		Smc	<453..>985	CDD:440809	56/304 (18%)
		Metallothio	<1071..1115	CDD:395080
kif3cb	NP_001017849.2	KISc_KIF3	20..351	CDD:276822	143/342 (42%)
		sbcc	454..>641	CDD:129705	60/323 (19%)