Protein Alignment Klp3A and kif3a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001017604.2
• Gene: kif3a / 550267
• ZFINID: ZDB-GENE-050417-71
• Length: 701
• Species: Danio rerio
• Alignment Length: 803
• Identity: 238/803 - (29%)
• Similarity: 379/803 - (47%)
• Gaps: 154/803 - (19%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSAD---GAPQVTVNR-------NESYTYNYVFDIDDSQKD 63
            |.|.:|.|||.:.|...|.:.:|  :.|   |.  :|||:       .:::|::.||..|..|.|
Zfish    18 VKVVVRCRPLNEKEKIMGHKQSV--TVDEIRGT--ITVNKLDISSEPPKTFTFDTVFGPDSKQLD 78

  Fly    64 LFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGV--LDDHVGVIPRAVHDIFTAIAE 126
            ::....:..:..:|.|||.||.||||||:|||:||    .||  :.:..|:||.:...:|..||:
Zfish    79 VYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTM----EGVRAVPELRGIIPNSFAHVFGHIAK 139

  Fly   127 MQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR----IIMPGLTELVVTSAQQVT 187
            .:.:.||.|..|::|:|.|:..||..     |..:...|||.|    :.:..|:..||.:|..:.
Zfish   140 AEGDTRFLVRVSYLEIYNEEVRDLLG-----KDQMQRLEVKERPDVGVYIKDLSGYVVNNADDMD 199

  Fly   188 DHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK--LDGKQSVTTSRFNLVDLAGSERCSKTL 250
            ..:..|...|:|.||.|||.|||||||||:|:..::  :||.|.|...:.:|||||||||..||.
Zfish   200 RIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNQHVRMGKLHLVDLAGSERQGKTG 264

  Fly   251 ASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPA 315
            |:|.|.||...||..|..|||||:||..|::. ::|||.|||||||||||||||.|:|.|.:.||
Zfish   265 ATGQRLKEATKINLSLSTLGNVISALVDGKST-HVPYRNSKLTRLLQDSLGGNSKTMMCANIGPA 328

  Fly   316 DYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGA 380
            |||..||:||||||:||..||||..:|.||..|.:...:..|::|:.:|..|.::|       |:
Zfish   329 DYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEIS-------GS 386

  Fly   381 AGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHD 445
            .|.|:...:|...|........:|.:::|.  .|:..::|.::        |:|.:|
Zfish   387 DGSGSDDMDEDDVGDGGERRRKRRGRKKVS--PDKMVEMQAKI--------EEERKA-------- 433

  Fly   446 KLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLS 510
                    |:.|||..|:.:                   |:...||::.:::|.....|....|.
Zfish   434 --------LEAKLDMEEEER-------------------NKARAELEKREKDLLKAQQEHHLLLE 471

  Fly   511 SRSHTE-----GGE---SGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRN 567
            ..|..|     ||.   :..:|..::|...:.|...::.. |.:||   |:|:.|::
Zfish   472 KLSALEKRVIVGGVDLLAKAEEQEKLLEESNNELEERRKR-AEQLR---RELEEKEQ-------- 524

  Fly   568 FSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNI-----KSKDISAKLAEERRKRLQLLEQE 627
             .|||.:          :|...|:.|.:....:|:.:     .:|...|.|.:|..:.::.|.:.
Zfish   525 -ERLDIE----------EKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHHREIEGLLEN 578

  Fly   628 ISDLRRKLITQANLLK--IRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKE 690
            |..|.|:|..|..::.  |..:.:|.|:|.......:.|.::|.: |..|.:       |.::..
Zfish   579 IRQLSRELRLQMLIIDNFIPQEYQEMIENYVHWNEDIGEWQLKCV-AYTGNN-------MRKQTP 635

  Fly   691 LTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGG 755
            ::..|.||           ........|.....||::           ||:..:.:|.:...||.
Zfish   636 VSDKKEKD-----------PFEVDLSHVYLAYTEESM-----------RQSLMKLERPRTSKNGK 678

  Fly   756 S--AAGSSNANAKTDSWVDRELE 776
            |  ..|....::|.::.::..|:
Zfish   679 SRPKTGRRKRSSKPEAVIESLLQ 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	148/344 (43%)
		Smc	<453..>985	CDD:440809	65/341 (19%)
		Metallothio	<1071..1115	CDD:395080
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	148/343 (43%)
		Smc	<424..>589	CDD:440809	44/230 (19%)