DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and kif7

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001014816.1	Gene:	kif7 / 544651	ZFINID:	ZDB-GENE-050307-1	Length:	1363	Species:	Danio rerio

Alignment Length:	1446	Identity:	354/1446 - (24%)
Similarity:	582/1446 - (40%)	Gaps:	353/1446 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFE 66
            |..:.|.|.||:|||||:..|:.......:....: ..:||:..:..:..::||:...:|::::.
Zfish     9 SKVEESAVQVAVRVRPLLPKEILHSHESCITSDPE-ERRVTLGNDRHFHCDFVFEDGSTQEEVYT 72

  Fly    67 TCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTA-FNGVLDDHVGVIPRAVHDIFTAIAEMQSE 130
            .|||..::...:|:|.|:.||||||||||||:|.| .:...||..|:|||||.:||..:.| ...
Zfish    73 NCVQPLIEAFFHGFNATVSAYGQTGSGKTYTIGEASISAFRDDEQGIIPRAVAEIFKLLDE-NDL 136

  Fly   131 FRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGS 194
            ..|:|..|::|:|:|.|.||...:|..| .:.||| .:..:::.|:.|..|....:|...|..|.
Zfish   137 IDFSVRVSYMEVYKEVFRDLLEVETASK-DIHIREDERGNVVLCGVKECEVEGLDEVLSLLESGK 200

  Fly   195 AGRAVAATAMNETSSRSHAIFTLTLVATK-----LDGKQSVTTSRFNLVDLAGSERCSKTLASGD 254
            ..|...||.||..|||||.|||:.:...:     .:|...:.:|:|:.||||||||..||..:|:
Zfish   201 TARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFVDLAGSERILKTGNTGE 265

  Fly   255 RFKEGVNINKGLLALGNVINALGSGQAAG-YIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYN 318
            |.||.:.||.|||.|||||.|||..:..| :||||.||:||:|:||||||:.||||||:||:..:
Zfish   266 RLKESIQINSGLLVLGNVIGALGDPKRKGTHIPYRDSKITRILKDSLGGNAKTLMIACISPSSSD 330

  Fly   319 VAETLSTLRYADRALQIKNKPVVN----------------------------------------- 342
            ..|:|:||.||.||..|:|:..||
Zfish   331 FDESLNTLNYAKRARNIQNRATVNCRGEPDRIEGLELQIKALRRALENRQRSETRIIARSDPEKR 395

  Fly   343 LDPHAAEVNMLK----------DVIQKLRVELLSGGKMS------------------SSLISAVG 379
            |.|...:|..|:          |...:|..||...|.::                  |.|.||.|
Zfish   396 LRPFEVDVRKLQAESAHYRTCTDSAYRLLTELQGEGTLNAGQILRVKEWLCGVEEERSGLTSASG 460

  Fly   380 A-AGLGAIPCEESLAGSMANA------------------------AEIQRLKEQ----VRTLQD- 414
            . :|:.:...|:|.|.....|                        |:||:|:::    :..|:|
Zfish   461 LDSGIESSSTEDSTALKRRQAVLNNQDLVKEDWRGEREDYTSQLQAQIQQLEQENTDFLVALEDA 525

  Fly   415 ------RNRKLQQ------ELHQSLLD-----LTEKEMRAHIAE-----QAHDKLR----SHVS- 452
                  ::.|||:      |||..|..     ....:.|.|.|.     |..|:|.    |.|.
Zfish   526 MEQYKQQSDKLQEQQDLIAELHSLLAQPGGAGFLHLKQRPHTAPINSLLQTPDRLTPPCDSDVGR 590

  Fly   453 ELKNKLD---------QREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELES-------- 500
            .|..:||         ..||.|:  :.|:|:........|.......:|.|:::.:|
Zfish   591 SLARQLDVGASVDSSSYSEQTQW--DGTHGNTHCESSRKLNRDEDGHMQTTRDKRKSINVTWTKK 653

  Fly   501 -----QG----------------HESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQ--MN 542
                 ||                |....:.:.|  |.....|...|.|.:.....|:.:.:  :.
Zfish   654 DIAIPQGPFGGTRTALPQTLGLCHPLGMQFNRR--TSNSSIGESSVWESVRGFGGEFCSDRGLLQ 716

  Fly   543 FAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAE----RRDLMDQLRN 603
            ...::|.::..:.:|:||.:.:::.     ..|.....|..::||.:||||    |.:|.:..:.
Zfish   717 AQQKIRELSITIRMKEELIKELVKT-----GKDAQAMNRQYSRKISELEAEAEQARVELTEAQKQ 776

  Fly   604 IKSKDISA-------KLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRT 661
            ::..::..       ..|:|.|:::...:.::..|::|....|.|..:..:...::|.|...::.
Zfish   777 LQELEVQGGRDAVDRSKAQECRRKIAAAQSKVQVLKQKQRDTAQLASLSAQSERRVQELERNVQN 841

  Fly   662 MKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEA 726
            ||:.:..|.|.:|.||::      .|..|....|.|.|..:.||..:|     |:::|:.|.||.
Zfish   842 MKQQQDLLQRRLREESQQ------KRRLETEMQKGKHRVKELEIKNEQ-----QQKILRIKTEEI 895

  Fly   727 LAANKRLKD-------ALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDA 784
            .|..::.:.       :||.|...:.|:.                     |:|.|:|.:|   |.
Zfish   896 AAFQRQRRSGSNGSVVSLEEQQKIEEQKR---------------------WLDEEMEKVL---DQ 936

  Fly   785 EHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTD- 848
            ...||.|                     ..|..::..|||..|..|..|    |.|:.|...:.
Zfish   937 RRGLEDL---------------------EGELTKREEILAKKEALLWER----SGLESKKLRSSQ 976

  Fly   849 -LDSRIRSLAEGVQSLGESRTVSKQLLKT----LVQQRRLQASSLNEQRTTLDELRAQLLDAQQQ 908
             |...:.:|:..::||....|....||::    ..||.|.:.|:|.:::..|.:.|.:|.|..:|
Zfish   977 ALSQDLLTLSSRIESLERELTERNGLLRSGSAQDSQQIRQEISNLRQEKELLLKQRVELDDKLRQ 1041

  Fly   909 EDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEEL--LSS 971
            .:..|........|.:|.:.|...|.|.|...:  |..||...|......|....::.:|  ||:
Zfish  1042 GNLLSPEEERTLFQLDEAIEALDAAIEYKNEAI--TQRQRQLRASGSMLTQWEMNLMAKLTYLSA 1104

  Fly   972 REA---LQQELDK---LRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSK 1030
            .|.   |.:..||   ||.:.:....|:......:::...:|               .|:.:..:
Zfish  1105 SETRALLCKYFDKVVSLREEERRLQMALAELELRVEEQQNLV---------------GWLEAALE 1154

  Fly  1031 SKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSG- 1094
            .:::::| |.:....::.:.|:..|    :|                 :||.:......|.|..
Zfish  1155 RQQLEAD-RRLTQQQKEHERNIQLL----LQ-----------------QCREQMDEGLAGRLRQY 1197

  Fly  1095 ----NNACSETCVCK-----------SNCRNPLNLKDHASQCGD--------GDGQKDETEDADK 1136
                :|...|...||           ..| .|:||.  ..||..        ...|....||...
Zfish  1198 EGLIHNLSKELNFCKIANQELNIKLREMC-GPVNLT--GEQCKGLNCDSLLLAGAQSRVAEDVKP 1259

  Fly  1137 SDDDGDDEPQTSKENAVKFVTPEAP-----GKVVASPKQTLQE-PKAAATPLMNSNVVE-DINGP 1194
            ..|  .:..|.|:|...:.|....|     ..:....:.|::| .:.||..|.|:.:|: .:|..
Zfish  1260 IID--AERVQKSREEMREPVNAPLPATWRRSSLPTEDQYTMEELRQRAACELPNNRIVQPGMNST 1322

  Fly  1195 KLAKMSGLAFDTPKRK 1210
            ..:..:.|....|:|:
Zfish  1323 HWSGSTSLPVTRPRRE 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	141/336 (42%)
		Kinesin	14..335	CDD:278646	137/328 (42%)
		Smc	<396..>994	CDD:224117	149/725 (21%)
		FlaC	522..633	CDD:225888	21/123 (17%)
		TCR	1075..1110	CDD:281618	9/50 (18%)
kif7	NP_001014816.1	KISc_KIF4	14..348	CDD:276823	141/336 (42%)
		KISc	15..354	CDD:214526	142/341 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..642		8/40 (20%)
		PspA_IM30	716..924	CDD:281941	48/223 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1314..1346		5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820