Protein Alignment Klp3A and Kif17

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_038967234.1
• Gene: Kif17 / 500571
• RGDID: 1562511
• Length: 1075
• Species: Rattus norvegicus
• Alignment Length: 1308
• Identity: 313/1308 - (23%)
• Similarity: 513/1308 - (39%)
• Gaps: 399/1308 - (30%)

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAV-------------ERSADGAPQVTVNRNESYTYN 52
            |:||.   |.|.:|.||:.:.|.:..|:..|             ..:||..|       :.:|::
  Rat     1 MASES---VKVVVRCRPMNKRERELNCQSVVTVDCARGQCFIQNPGAADEPP-------KQFTFD 55

  Fly    53 YVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD--HVGVIPR 115
            ..:.|:...:.::.......|:.:..|||.||.|||||||||::||    .|:.|.  ..|:|||
  Rat    56 GAYYIEHFTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTM----QGLPDPPCQRGIIPR 116

  Fly   116 AVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR-IIMPGLTELV 179
            |...:|.:: :.....:|.|..|::|:|.|...||..:.|:.:  ::::|...: :.:.||:...
  Rat   117 AFEHVFESV-QCAENTKFLVRASYLEIYNEDVRDLLGADTKQR--LELKEHPEKGVYVKGLSMHT 178

  Fly   180 VTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLD--GKQSVTTSRFNLVDLAG 242
            |.:..|....:..|...|||..|.||:.|||||:|||:.:....:|  ||..:...:.|||||||
  Rat   179 VHNVAQCERVMETGWKNRAVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAG 243

  Fly   243 SERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITL 307
            |||.|||.|:|:|.||...||..|.||||||:||..|:.. :||||.||||||||||||||:.||
  Rat   244 SERQSKTGATGERLKEATKINLSLSALGNVISALVDGRCK-HIPYRDSKLTRLLQDSLGGNTKTL 307

  Fly   308 MIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVEL---LSGGK 369
            |:||:||||.|..|||||||||:||..|||||.:|.||..|.:...::.|::|:..|   :..|.
  Rat   308 MVACLSPADNNYDETLSTLRYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGN 372

  Fly   370 MSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVR-TLQDRNRKLQQELHQSLLDLTEK 433
            :|:.|.:...:   |.:..||.|........:.:..|:.:| ..::|..:|:.:..      .|:
  Rat   373 LSALLSTQTPS---GPVHPEEKLPSPTTVQQDTEAEKQMIREEYEERLARLKADYE------AEQ 428

  Fly   434 EMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEEL 498
            |.|.        :|:..::.::|..|                             |:|...||.|
  Rat   429 ESRV--------RLQEDITAMRNSYD-----------------------------VKLSTLQENL 456

  Fly   499 ESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHER 563
                         |...|.|........|  .:....||     :|            |..|||.
  Rat   457 -------------RKEKETGALCPGAAWE--PTSCVPYT-----WA------------KGPLHEA 489

  Fly   564 IMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEI 628
            :::         .:|   ||          :.::|.:.......:.|..|..|
  Rat   490 VLK---------AEV---LC----------KTEVMSRAEVTSGPEYSPPLQYE------------ 520

  Fly   629 SDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQ 693
            :.::..:::..::|.                              |||..:.:          ..
  Rat   521 TAVKPTVLSMPDMLP------------------------------RGEVTRSQ----------AP 545

  Fly   694 LKSKDRKMQSEIVRQQTLHSKQRQVLK-RKCEEALAANKRLKDALERQASAQAQRHKYKDN--GG 755
            |.|::..|:..  |.:...|.:...|: ....||....:.|.:.........|:...:.|.  ..
  Rat   546 LTSEEPNMEPS--RSEVFESNESSNLEDSSMSEAYPGPEELSNVEFSMPGVLAESRYFPDEYLNP 608

  Fly   756 SAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQA 820
            .|||..                    ::||||                 :|.|.|.:|      .
  Rat   609 EAAGCP--------------------LEAEHS-----------------VQDEPTLEP------L 630

  Fly   821 RILASLEE---ELEMRNAQIS------DLQQKVCP---------TDL----DSR----------I 853
            ||||||::   |:|.:.|::|      ||.|.|.|         |||    |::          :
  Rat   631 RILASLQDPFAEVEAKLARLSSTVAMTDLSQTVVPQVPQQQPSSTDLLEPSDTKSEVDVADNVLL 695

  Fly   854 RS-------LAEGVQSLGE-----------------SRTVSKQLLKTLVQQRRLQASSLNEQRTT 894
            |:       :||.|.|..|                 |.....|.|..:...||   .|:..:...
  Rat   696 RTEPDLSMKVAEEVVSEAETGVWMESEAHVAHVAQVSEEAQPQPLLAMASVRR---ESIGVEVAV 757

  Fly   895 LDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQ 959
            |.|   :|....||:..|  ||:||:.|......|:.:..:||     ....:|:|       |:
  Rat   758 LTE---ELQPVDQQQVLA--RLQLLEQQVVGGEQAKNKDLKEK-----HRRRKRYA-------DE 805

  Fly   960 QRNQILEELLSSRE------------ALQQEL---DKLRAKNKSKSKAVKSEPQDLDDSFQI--V 1007
            ::.|::..|.:|.|            ::|:|:   .||..|.:.|.:|.:.|.:||...||:  :
  Rat   806 RKKQLVAALQNSDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQKKLRAAEVEIKDLQSEFQLEKI 870

  Fly  1008 DGNETVVLSDVSDDPDWVPSTSKSKRIQSDSR------NVISPPEKQDANVTSLGNSSIQSLNST 1066
            |...|:                  :|.:.||.      ..:.|..::|.|.     |:::.:...
  Rat   871 DYLATI------------------RRQERDSMLFQQLLEQVQPLIRRDCNY-----SNLEKIRRE 912

  Fly  1067 SATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQCGDGDGQKDET 1131
            |:.::.                    :|.....|..:.|::.  |:.:.         .|.:::.
  Rat   913 SSWDED--------------------NGFWKIPEPIILKTSL--PVAVP---------TGTQNKP 946

  Fly  1132 EDADKSDDDGDDEPQTSKENAVKFVTPEAPGKVVAS----PKQTLQEPKAAATPLMNSNVVEDIN 1192
            .....:.|.|  ||...:|:..|.:...:..:.:||    .|:..|.........:|.:.:|..:
  Rat   947 ARKTSAVDSG--EPHMQEEDRYKLMLSRSDSENIASNYFRSKRASQILSTDPMKSLNCSTLEPTH 1009

  Fly  1193 GPKLAKMS 1200
            .|:.::.|
  Rat  1010 PPRRSRRS 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	139/346 (40%)
		Smc	<453..>985	CDD:440809	107/605 (18%)
		Metallothio	<1071..1115	CDD:395080	4/43 (9%)
Kif17	XP_038967234.1	Motor_domain	4..335	CDD:473979	140/348 (40%)