Protein Alignment Klp3A and LOC4576148

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_061512564.1
• Gene: LOC4576148 / 4576148
• VectorBaseID: AGAMI1_001728
• Length: 1254
• Species: Anopheles gambiae
• Alignment Length: 1268
• Identity: 472/1268 - (37%)
• Similarity: 673/1268 - (53%)
• Gaps: 200/1268 - (15%)

  Fly     6 PSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTV----NRNESYTYNYVFDIDDSQKDLFE 66
            |.||.||:|:||:.|||..|||:..||::|.||||:.|    ..::.::|:|||.....|..|:|
Mosquito    29 PECVKVAVRIRPMSQSEQARGCQTVVEQAAPGAPQLLVCGGRTPSDVFSYSYVFPPSTVQSQLYE 93

  Fly    67 TCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAI----AEM 127
            ..|...:.||..|||.||||||||.||||:||||.|.|.:|..|||||||::|||..:    ||:
Mosquito    94 VAVSPMLHKLFAGYNATILAYGQTSSGKTFTMGTHFAGEVDSSVGVIPRAINDIFRLMADGTAEV 158

  Fly   128 QSEFRFAVTCSFVELYQEQFYDLFSSKT--RDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDH 189
            .:.....||||::|:||:|.:||.:.|.  .::..||||| |...||:.||||:.....|...|.
Mosquito   159 TAHVDTRVTCSYIEVYQDQVFDLLAEKPAGTERQPVDIREAVGGDIILQGLTEVAAGGVQSAFDC 223

  Fly   190 LIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGD 254
            |.|||.||.|.|||||..||||||||||||..|..|....||.|:|:|||||||||..||..:||
Mosquito   224 LARGSLGRVVRATAMNNVSSRSHAIFTLTLHHTARDDPAVVTRSKFHLVDLAGSERSKKTDTTGD 288

  Fly   255 RFKEGVNINKGLLALGNVINALGSGQ-AAG--YIPYRQSKLTRLLQDSLGGNSITLMIACVSPAD 316
            ||||||.|||.||||||||.||||.. |||  :||||.|||||||||||||||.|||||||||||
Mosquito   289 RFKEGVQINKCLLALGNVITALGSSAGAAGKMHIPYRSSKLTRLLQDSLGGNSYTLMIACVSPAD 353

  Fly   317 YNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVE--LLSGGK---------- 369
            ||::||.||||||:|..:|||||:||.||..|.:..|:.::|.||||  :|..|:
Mosquito   354 YNLSETYSTLRYANRVCKIKNKPIVNQDPQQARIKQLEAIVQDLRVEVMMLKSGREGCPPTTDKD 418

  Fly   370 --------MSSSLISAVGAAGLGAIPCEESLAGSMAN-AAEIQRLKEQVRTLQDRNRKLQQELHQ 425
                    :.|.|:..:....|...| ..|.|||.:: :|..|:       ||:.||.||::|..
Mosquito   419 GTFRVPQPVHSPLVRGLTETQLLRSP-RSSEAGSASDPSAGYQK-------LQEANRCLQKQLQA 475

  Fly   426 SLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVE 490
            ::.:|...|.|:.:||    ||...:.:|           .|.|...|::.:|.          |
Mosquito   476 TMHELEVHEERSMLAE----KLLEDIEQL-----------LGREAQPGEDGLRQ----------E 515

  Fly   491 LQRT----QEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSH-----SEEYTNKQMNFAGE 546
            |.|.    |:|:.|.|..|.......|......:.|..|.:.|.:.     ||.:|.:|:....|
Mosquito   516 LARLLTAHQDEVYSLGSLSAAYGPPLSRMIRPSTAGAGVDDPLRTEEFERKSEFHTQQQIRIHSE 580

  Fly   547 LRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQ-------LRNI 604
            |..:.|::.||:|||.:...|.:.:.|.....:..|..| :.:.|.:.|.|..|       |.|.
Mosquito   581 LTQLKREIALKEELHRKCQGNSAAVQSYTSRRERELTEQ-LHEYEGQMRSLEGQLAELNALLENT 644

  Fly   605 KSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKL 669
            |:.:..:|||||||:::|.||.|::::|:|...||.|||:.:|:.|:|..||:||:.||.::|||
Mosquito   645 KASEKRSKLAEERRRKVQQLEAELAEMRQKSARQAKLLKLHEKDAERIAGLSSEIQQMKATRVKL 709

  Fly   670 IRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLK 734
            ::.:|.|||.||||:..||||:||||:||||.|.::.:.::.:|.|:::::||.:|.:..|||||
Mosquito   710 LKTLRTESESFRQWRASREKEITQLKAKDRKQQYQLQKLESTYSMQKRIMQRKMDETIQVNKRLK 774

  Fly   735 DALERQASAQAQRHKYKDNGGSAAGSSN----ANAKTDSWVDRELEIILSLIDAEHSLEQLMEDR 795
            ..||||     ||.|      :|||:.:    ..|:...||.:|||:|.:.::|..:|..|...|
Mosquito   775 ATLERQ-----QRSK------TAAGARDRAAMRGAEAARWVKQELELICNTVEATVTLSVLRAQR 828

  Fly   796 AVINNHYHLLQQEKTSDPAEAAEQARILASLEE---ELEMRNAQISDLQQKVCPTDLDSRIRSLA 857
            |........::.:....|...||..|:...:::   :|:.|||||.|||.|:...|.||::.:..
Mosquito   829 AQEVKKIKQMEGQCAELPEGGAEYQRLRQDIQQCQLDLDYRNAQIVDLQTKLHTIDTDSQVAAFG 893

  Fly   858 EGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQ-----QQEDAASKRLR 917
            ||:..|.|:|...:|||:.|||           ..|.|.|.|.||:|.|     |:|:.|..|.:
Mosquito   894 EGLAKLPEARDAFQQLLEQLVQ-----------THTRLIETRFQLVDLQATGDCQEEELAQVRAQ 947

  Fly   918 L--LQSQHEEQMLAQQRAYEEKVSVLI--RT----------ANQRWAEARSPAEDQQRNQILEEL 968
            |  ...|:.|:::..::.||:|:::|:  ||          .|...||.....|:.....:.||.
Mosquito   948 LEAADQQYREEVVQLEKRYEDKLALLLMQRTGGAAAATAAPTNGTGAEGEEVEEEAGTGAVHEEA 1012

  Fly   969 LSSREALQQELD-------KLRAK-NKSKSKAVKS--------EP--------QDLDDSFQIVDG 1009
            :...|.|:.||:       .||.: :::..:.|:.        :|        :.|:|.:..|.|
Mosquito  1013 IRRIEQLRDELELYKRSAQMLREQLDEATKRPVRKRRMPNHLLDPDFNTEFDLEFLEDEYNQVGG 1077

  Fly  1010 NETVVLSDVSDDPDWVP---STSKSKRIQSDSRNVISPPEKQDANV-TSLGNSSIQSLNST---S 1067
            .:       .|:|:..|   .|...||            :||..:: .:|.:|:|||..||   :
Mosquito  1078 TD-------DDNPELDPDFRGTPLHKR------------KKQSMSIRETLLSSTIQSNASTVGRA 1123

  Fly  1068 ATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQCGDGDGQKDETE 1132
            ||..|.  ..|.|...|.::||||...::.|..:|.|...|.|.:           |:|....:.
Mosquito  1124 ATGGGS--ASCSCTGNCGSRRCGCHKQDSLCGASCRCPPTCVNRI-----------GEGVPAASL 1175

  Fly  1133 DADKSDDDGDDEPQTSKENAVKFVTPEAPGKVV 1165
            |..........|..|:..||    |.:||.:.|
Mosquito  1176 DVSDGSTVAPVEDTTAAANA----TVDAPKQAV 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	198/342 (58%)
		Smc	<453..>985	CDD:440809	184/580 (32%)
		Metallothio	<1071..1115	CDD:395080	13/43 (30%)
LOC4576148	XP_061512564.1	None