DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and sub

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	170/633 - (26%)
Similarity:	256/633 - (40%)	Gaps:	192/633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSEDPSCVA-------------VALRVRP--------LVQSE---LDRGCRIAVERSADGAPQVT 42
            ::|..||..             |.||:||        :|..|   |...|::       .:....
  Fly    68 ATEGASCATSAADSSNVETGPQVFLRLRPVKDASKAYIVSEEANVLITSCKV-------DSTSNN 125

  Fly    43 VNRNES-YTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVL 106
            |||.|. :.:..:||....|:|:::|||..|:   :....|||:.||.:|||||||:       |
  Fly   126 VNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKI---MEEECVTIMTYGTSGSGKTYTL-------L 180

  Fly   107 DDHV--GVIPRAVHDIFT--------------------------AIAEMQSEFRFAVTC------ 137
            .|.|  |:||||:.:|||                          ::.|:|...:....|
  Fly   181 GDDVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAH 245

  Fly   138 ----------------------------SFVELYQEQFYDLFS-----SKTRDKATVDIREVKNR 169
                                        ||||:|.|..|||.:     .|..:....:::.|.|:
  Fly   246 HQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNK 310

  Fly   170 --IIMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTT 232
              :.:.|||.:.|||:::....|..|......|:|::|..|||||.:||:.::.....|   :||
  Fly   311 GHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSG---ITT 372

  Fly   233 -SRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQA---AGYIPYRQSKLT 293
             |.:...|||||||.:.|..||.|.||..|||..|:.||..::|..:.|.   |..||||.||||
  Fly   373 QSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLT 437

  Fly   294 RLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQ 358
            .|||.:|.|.....||..|:|.|....|.|:.|.:|..|     |.::..:|          ||:
  Fly   438 MLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIA-----KNIIFKEP----------VIK 487

  Fly   359 KLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQEL 423
            :.||...  |.|..|.:|.          ||..               :..:.|:|.|.:||.|:
  Fly   488 QHRVSYC--GFMEFSKMST----------CEGG---------------DYTKELEDENVRLQLEI 525

  Fly   424 HQSLLDLTEKEMRAHIAEQ--AHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNR 486
            .|...|        |:.:.  ..:|||..::....::.|..:.|:       ::|.....|:..|
  Fly   526 EQLKYD--------HVLQMQLLEEKLRRELTATYQEIIQNNKKQY-------EDECEKKLLIAQR 575

  Fly   487 VHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSE 534
                        ||:...|.||   |.:.|..|...||:.|:.:..|:
  Fly   576 ------------ESEFMLSSQR---RRYEEQIEDLKDEIEELKNPASD 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	128/426 (30%)
		Kinesin	14..335	CDD:278646	124/405 (31%)
		Smc	<396..>994	CDD:224117	29/141 (21%)
		FlaC	522..633	CDD:225888	4/13 (31%)
		TCR	1075..1110	CDD:281618
sub	NP_001286548.1	KISc	89..477	CDD:276812	126/412 (31%)
		Kinesin	93..479	CDD:278646	125/410 (30%)
		GBP_C	<512..603	CDD:303769	28/120 (23%)
		coiled coil	576..586	CDD:293879	5/12 (42%)
		coiled coil	592..603	CDD:293879	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437852
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840