DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and kif4a

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001006741.1	Gene:	kif4a / 448410	XenbaseID:	XB-GENE-5932310	Length:	1231	Species:	Xenopus tropicalis

Alignment Length:	1244	Identity:	434/1244 - (34%)
Similarity:	670/1244 - (53%)	Gaps:	145/1244 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLF 65
            |..::...|.||||.||||..||:.||:..: ....|.|||.|...:|:||:||||....|::::
Frog     1 MGKDEGIPVRVALRCRPLVPKELNEGCKTCL-TFVPGEPQVIVGTEKSFTYDYVFDPSTEQEEVY 64

  Fly    66 ETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH--VGVIPRAVHDIFTAIAEMQ 128
            .:.|...:|.|..|||.|:||||||||||||:||.|:....::.  ||||||.|..:|..| |.:
Frog    65 NSAVGPLIKGLFKGYNATVLAYGQTGSGKTYSMGGAYTHDQENEPTVGVIPRVVKALFREI-EQR 128

  Fly   129 SEFRFAVTCSFVELYQEQFYDLFSSKTRDKA-TVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLI 191
            ||:.|.:..|::|:|.|:..||..: .|||. .:.||| .|..|.:.||||..|.:|......|.
Frog   129 SEWEFHLKVSYLEIYNEEILDLLYA-ARDKTNAISIREDPKEGIKICGLTERDVKTALDTVSCLE 192

  Fly   192 RGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRF 256
            :|::.|.||:||||..|||||||||:::...|...|.:...|:.:|||||||||..||.|.|||.
Frog   193 QGNSSRTVASTAMNSQSSRSHAIFTISIDQRKEGDKNNSFRSKLHLVDLAGSERQKKTKAEGDRL 257

  Fly   257 KEGVNINKGLLALGNVINALGSGQAAG-YIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVA 320
            |||::||:|||.|||||:|||.....| ::|||.|||||||||||||||.|||||||||||.|:.
Frog   258 KEGISINRGLLCLGNVISALGDENKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNME 322

  Fly   321 ETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGA 385
            |||:||||||||.:|||||:||.||.|||:..||..:|:|:|.||.             |.| |.
Frog   323 ETLNTLRYADRARKIKNKPIVNTDPQAAELQRLKQQVQELQVLLLQ-------------AHG-GT 373

  Fly   386 IPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSH 450
            :|    :..||..:..:|.|.|:.:.|::.|.||.:||.::.:...:...:..:.||.::||.|.
Frog   374 LP----VLNSMEPSDNLQSLLERNKNLEEENGKLSRELSEAAVQTAQFLEKIILTEQQNEKLASK 434

  Fly   451 VSELKN----KLDQREQAQFGNENTNGDNEMRD---FSLLVNRVHVELQRTQEELESQGHESRQR 508
            :.|||.    |:|.:...:     |..|.|:::   ..|.:.:|.::||.....:.:......:.
Frog   435 IEELKQHAACKVDLQRLVE-----TLEDQELKENVGVILDLQQVIMQLQDESSGIAASIEAMTEV 494

  Fly   509 LSSRSHTEGGESGGDEVHEMLHSHSEEYTN----KQMNFAGELRNINRQLDLKQELHERIMRNFS 569
            ::|...:|.....|::      ..|:.:|.    :|...:.||..:|:.|.||:.|..::.:|.|
Frog   495 VASSPESEEPRDSGEK------RSSDAFTTDHALRQAQLSKELIELNKALLLKEALARKMAQNDS 553

  Fly   570 RLDSDDEDV--KLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLR 632
            :|:....:.  .::....::..|:.|:.||:..|.:.|.....|||:|.||||||.||.::::|:
Frog   554 QLEPIQSEYLNNIKQLESEVGALQKEKEDLIMALHSAKKDTNQAKLSERRRKRLQELEGQMTELK 618

  Fly   633 RKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSK 697
            :||..|:.|||:|:...:.:..|:.||:.||..:|:|:|.|:.::||||.||..:.||:.|||.|
Frog   619 KKLGEQSKLLKLRESTEKTVTKLNHEIQGMKVQRVQLMRQMKEDAEKFRTWKQQKTKEVIQLKEK 683

  Fly   698 DRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSN 762
            |||.|.|:::.:....||..||:||.|||..||||||:||.||..|..:|...::.|...|.|
Frog   684 DRKRQYELLKLERDFQKQANVLRRKTEEAATANKRLKEALLRQKEAMEKRKDSQNRGMEGAAS-- 746

  Fly   763 ANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTS---------------- 811
               :..||:..|:|:::|..:|:..|..|:|||.::......|:|:|.:
Frog   747 ---RVKSWLANEVEVLVSTEEAQRHLNDLLEDRKILAQDIAQLKQKKDAGERIPTKMRRRTYTVA 808

  Fly   812 ---DPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSR-IRSLAEGVQSLGESRTVSKQ 872
               :..|.:...:.:.|||.|:|:|:|||:|||||:...|.:.. ::...|.:.::.|::...|.
Frog   809 ELENMEEESSVTKQIESLETEMELRSAQIADLQQKLLDADAEEEMVKRRWETITNIMEAKCALKY 873

  Fly   873 LLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEK 937
            |:..||..:    .::::..:::.:.||.:.|.|:.......::..::::|:.|::..::.::||
Frog   874 LITELVSSK----VAVSKLESSVKQNRAHIADLQKTIFEERNQMAEMETEHQSQLMQLEQQHQEK 934

  Fly   938 VSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNK--SKSKAVKSEPQDL 1000
            :..|:....|:.|......|:....|:.|     ||  :|.:::||.:::  .|.|.:..:.|.|
Frog   935 ILYLLSQLQQKQAPVPVQVEEPPAEQMTE-----RE--KQLMERLRFQDEEIEKMKELCEKNQQL 992

  Fly  1001 ---DDSFQ-------IVDGNE------TVVLSDVSDDPDWVPSTSKSKR-------------IQS 1036
               :|.::       :..|.:      |.||:......|:||...:.||             :.|
Frog   993 LQENDMYKQKLALLHVASGKKLHNILPTAVLNSPDSPFDFVPPKPRGKRRTNAKAAAVILEDLLS 1057

  Fly  1037 DSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSET 1101
            :|.   |..|..|.| ...||:|.||....|         ||.|:.:|..|.|||......||:.
Frog  1058 ESE---SEGESDDKN-WEPGNNSKQSKKLPS---------GCSCKARCGNKMCGCRKTKQNCSDD 1109

  Fly  1102 CVC-KSNCRNPLNLKDHASQCGDGDGQKDETEDADKSDDDGDDEPQTSKENAVKFVTPEAPGKVV 1165
            |.| .|.|||    :|::...|:.|.|..|:|::.|.|..||.....|      |.||..    |
Frog  1110 CFCDPSKCRN----RDNSMDEGNADDQSHESENSIKIDYPGDVTAGGS------FFTPPC----V 1160

  Fly  1166 ASPKQTLQE 1174
            ...|:.|:|
Frog  1161 TPTKKVLRE 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	175/333 (53%)
		Kinesin	14..335	CDD:278646	171/325 (53%)
		Smc	<396..>994	CDD:224117	176/632 (28%)
		FlaC	522..633	CDD:225888	33/116 (28%)
		TCR	1075..1110	CDD:281618	14/35 (40%)
kif4a	NP_001006741.1	KISc_KIF4	7..338	CDD:276823	175/333 (53%)
kif4a	NP_001006741.1	PTZ00121	<432..1003	CDD:173412	165/597 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1226
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69022
Inparanoid	1	1.050	620	1.000	Inparanoid score	I865
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	1	1.000	-	-		FOG0003140
OrthoInspector	1	1.000	-	-		oto103627
Panther	1	1.100	-	-	O	PTHR47969
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160