DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Kif3C

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	207/755 - (27%)
Similarity:	340/755 - (45%)	Gaps:	171/755 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGA----PQVTVNRNESYTYNYVFDIDDSQKDLFETCV 69
            :.|.:|.||:.|:|.:|.|:..||.:....    |...:::.:.:.::.|:::....:.:::...
  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDEMC 69

  Fly    70 QAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRFA 134
            .:.|:..:.|||.||.||||||.|||:||....|  ..:..|:||:....||..|: |.:..|:.
  Fly    70 YSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDEN--FSNSTGIIPKCFDHIFERIS-MTTNVRYL 131

  Fly   135 VTCSFVELYQEQFYDLFSSKTRDKATVD--IREVKN-RIIMPGLTELVVTSAQQVTDHLIRGSAG 196
            ...:::|:|.|:..||. :|..:...::  ::|:.. .:.:|.||...|.:|.|..|.|..|:..
  Fly   132 ALVTYLEIYNERIRDLL-NKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNKN 195

  Fly   197 RAVAATAMNETSSRSHAIFTLTLVATKL------DGKQSVTTSRFNLVDLAGSERCSKTLASGDR 255
            |..|||.||:.|||||.|||:||..:..      |....:...:.:|||||||||..||.|.|||
  Fly   196 RVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDR 260

  Fly   256 FKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVA 320
            .||...||..|.||||||::|..|:|. ::|:|.||||||||||||||:.||||:|:||.|.:..
  Fly   261 LKEASQINLSLSALGNVISSLVDGKAK-HVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324

  Fly   321 ETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGA 385
            ||:||||||.||..|.|||.:|.||..|.:...::.|..|:       :|
  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLK-------RM--------------- 367

  Fly   386 IPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSH 450
                            :|..::.:....|.|:.::..|                      |:..|
  Fly   368 ----------------LQESQQIINKNNDPNKIIKSPL----------------------KIIQH 394

  Fly   451 --VSELKN----KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRL 509
              ::..||    .|.:..:|.|...|:           ::.:.:..|.:::||::.|. .||..|
  Fly   395 TNMNSTKNVQIIDLGRNCKASFKTNNS-----------ILTKPNFPLIQSKEEVQLQA-RSRIDL 447

  Fly   510 SSRSHTEGGESGGDEVHEMLHSHSEEYTNKQM--NFAGELRNINRQLDLKQELHERIMRNFSRLD 572
            ..||..     ||:.:|:.      |...|.|  .:|.:     |.|       ..|....||:.
  Fly   448 IKRSLI-----GGERIHDF------ELKEKHMARKYAAQ-----RHL-------SAIAIALSRVK 489

  Fly   573 SDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLIT 637
            .:|.|:           |:.....:..::      ||......:.::::::||.|:|||..:...
  Fly   490 CEDRDL-----------LQGHYATITQEI------DIKNDYIRKCKEKIKMLEMEVSDLNSEFQL 537

  Fly   638 QANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKF-RQW---------------KMV 686
            .      |:...::|:||..:::..::    |.........|| |.|               ||.
  Fly   538 D------REDYLDEIRNLGRQVKFHQQ----LFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMW 592

  Fly   687 R--EKELTQLKSKDRK-----MQSEIVRQQTLHSKQRQVL 719
            |  |.:|.:|....:|     :...::..:..|:.|.:::
  Fly   593 RIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNNQNEIV 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	134/339 (40%)
		Kinesin	14..335	CDD:278646	133/333 (40%)
		Smc	<396..>994	CDD:224117	62/355 (17%)
		FlaC	522..633	CDD:225888	22/112 (20%)
		TCR	1075..1110	CDD:281618
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	134/338 (40%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	133/333 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840