Protein Alignment Klp3A and Klp98A

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1319
• Identity: 325/1319 - (24%)
• Similarity: 529/1319 - (40%)
• Gaps: 301/1319 - (22%)

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVE-------------RSADGAPQVTVNRNESYTYNY---VF 55
            |.:.||:||||....|:|...::.:|             :|...|.:   :.:..:|::|   .|
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGR---DNHHDFTFDYSYWSF 63

  Fly    56 DIDD----SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPR 115
            |.:|    :|:.::.......|.....|||..:.||||||||||:| |||..|      .|:|||
  Fly    64 DAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNN------PGLIPR 122

  Fly   116 AVHDIFTAI-AEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLT 176
            ...::|..: ...:|...:....|::|:|.|:..||.::::....   :|..::|.:.|   .|:
  Fly   123 ICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHG---LRVREHRSLGPYVENLS 184

  Fly   177 ELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLV-ATKLDGKQSVTTSRFNLVDL 240
            :..|:...::.:.:.||:|.|..|:|.||:||||||||||:|.| |..::...|.|.|:.:||||
  Fly   185 QHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDL 249

  Fly   241 AGSERCSKTLASGDRFKEGVNINKGLLALGNVINAL--------------------GSGQAAGYI 285
            |||||.:.|.|:|.|.|||.:|||.|:.||:||:||                    |:.:...||
  Fly   250 AGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYI 314

  Fly   286 PYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEV 350
            |||.|.||.||:|||||||.|:|||.:||||.|.:|||||||||:||..|.|||.||.|.:...:
  Fly   315 PYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLI 379

  Fly   351 NMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDR 415
            ..|::.|.||:..|                                  |.:|..|:..::.|.|.
  Fly   380 RELREEINKLKSML----------------------------------AGDIHSLQPSLKVLADL 410

  Fly   416 NRKLQQELHQSLL--DLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFG--NENTNGDNE 476
            .:|   |..:.:|  :.|||...|....|....|....|.:...||.......|  |:.|.|
  Fly   411 QKK---EAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHLIGIHNDVTTG--- 469

  Fly   477 MRDFSLL--VNRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSH--SEEYT 537
            :..:||.  ..|:..|.....:::|..|...|.:..| ...:||.       ..||..  ::.:.
  Fly   470 VTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCS-IFLKGGV-------VTLHPWPLAQCWV 526

  Fly   538 N-------KQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERR 595
            |       ||:: .|::..:.|             .|..|.::..|..|||      .||...:.
  Fly   527 NAHLIDEPKQIS-QGDIILLGR-------------TNIFRFNNPAEAAKLR------KDLSRSQL 571

  Fly   596 DL--MDQLRNIKSKDISAKLAEE-------RRKRLQLLEQ--------EISDLRRKLI-TQANLL 642
            |:  :..:.:.|...::..:..:       :|...|...|        |:.|..||:: |..|.|
  Fly   572 DMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENAL 636

  Fly   643 KIRDKEREKIQN-LSTEIRTMKESKVKLIRAMRGESEKF--------RQWKMVREKELTQLKSKD 698
            |..:.||.::.: ..|::|.:.|..::|      |.|:.        |:.:::..|::...:..:
  Fly   637 KQLNVERVQMHDQYKTKVRKLTEELIRL------EQEEMDGLQLLNCREQELIARKDMLLWEKNN 695

  Fly   699 RKMQSEIV-RQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSN 762
            .|:|.:|| ||.:....|....||...|.:|     |:..|.|...:......|...|:....
  Fly   696 EKVQIDIVCRQISAFQTQLDSKKRDFSEYVA-----KELQELQDCGKLDEMGMKIEEGTPLND-- 753

  Fly   763 ANAKTDSWVDRELEIILSLIDAEHSLE----QLMEDRAVINNHYHLLQQEKTSDPAEAAEQARIL 823
                         |::|.:.|   ||:    |.::|....||      :|......:.||:.|||
  Fly   754 -------------ELLLQVSD---SLDLFAAQFIKDTVRRNN------EEIRKLDEQIAEKERIL 796

  Fly   824 ASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSL 888
            .:...::...:..:.::|.::      .|:|  .|..:|..||     |.::...|..:||..:.
  Fly   797 NASTTKIAKVDETMLEIQAQL------ERLR--LERAESEAES-----QAMRAKKQNMKLQLGNK 848

  Fly   889 NEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEAR 953
            :...:|                          |.:|...:::...||  ......||....:...
  Fly   849 SMSTST--------------------------STNEADDVSKSDTYE--TCDTFHTAQSNLSLVS 885

  Fly   954 SP--AEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLS 1016
            ||  .|.||.........:..||.....|.|...::..|:...:.|..       ..|:.:|.:.
  Fly   886 SPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSS-------GSGSGSVGIG 943

  Fly  1017 DVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSAT--EDGKRCKGCK 1079
            .....|...||   |:.|.|||...:     ...|...|.|..:.:......|  ||...|..|:
  Fly   944 GSGSAPSCTPS---SQAIMSDSGVCL-----DSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCE 1000

  Fly  1080 CRTKCTTKRCGC----LSGNNACSETCVCKSNCRNPLN---LKDHASQCGDGDGQKDETEDADKS 1137
            ........|..|    |....|..:..:.| |....||   |.:|.:          :.:|..:.
  Fly  1001 LGRHSDVARPYCPLHSLRRKIAAQKALIMK-NLETDLNKAQLDEHIA----------DLQDLQRR 1054

  Fly  1138 DDDGDDEPQTSKENAVKFVTPEAPGKVVASPKQTLQEPKAAATPLMNSNVV---------EDING 1193
            ....:.|...|.::.      ||..:..|..:..::.....|:.:|.|:|:         ..|..
  Fly  1055 YIQMEQEMLQSVQDL------EAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTSQIYS 1113

  Fly  1194 PKLAKMSGLAFDTPKRKFF 1212
            |.:.:......:.|:.:.|
  Fly  1114 PSMTRSCPSMREFPEGEHF 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	142/374 (38%)
		Smc	<453..>985	CDD:440809	112/578 (19%)
		Metallothio	<1071..1115	CDD:395080	11/50 (22%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	146/380 (38%)
		Kinesin_assoc	370..478	CDD:465047	31/147 (21%)
		FHA_KIF16	449..556	CDD:438760	25/131 (19%)
		SMC_N	624..>864	CDD:481474	61/313 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	1/2 (50%)