DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Kif19A

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster

Alignment Length:	692	Identity:	218/692 - (31%)
Similarity:	339/692 - (48%)	Gaps:	130/692 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VAVALRVRPLVQS-----ELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETC 68
            :.||:||||.:::     |:..|..:..:   ||..    :|...|:|::||..:|||:.:::|.
  Fly    36 LVVAVRVRPSMEATERCIEVISGGSLLYD---DGGK----SRPRQYSYDHVFRENDSQEQVYKTT 93

  Fly    69 VQAKVKKLLNGYNVTILAYGQTGSGKTYTM----------------GTA---FNGVLDDHVGVIP 114
            ....|:.:|||.|..:.|||.||||||:||                .||   ...|....:|::.
  Fly    94 TAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSSQDIGLMV 158

  Fly   115 RAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVK--NRIIMPGLTE 177
            ||:.|||:.| |....:...|:.|::|:|.|...||.:    ....:::||..  .||.:.||:|
  Fly   159 RAIEDIFSHI-ESAEAYSCRVSISYLEIYNELIRDLLN----PGGPLELREDHRGQRITVAGLSE 218

  Fly   178 LVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVA-TKLDGKQSVTTSRFNLVDLA 241
            :..:|.::|...|::|:..|.:..||.|:|||||||:.::.:.| |.|..||    .|..|.|||
  Fly   219 ITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTPLGTKQ----GRLFLTDLA 279

  Fly   242 GSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSIT 306
            ||||..||...|.|.:||.:||:.|||||||||.|..|  |.|:.||.|||||||:::|.|...|
  Fly   280 GSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGG--ARYVNYRDSKLTRLLKEALSGRCKT 342

  Fly   307 LMIACVSPADYNVAETLSTLRYADRALQIKNK--PVVNLDP--------HAAEVNMLKDVIQKLR 361
            :|||.|:|...:..||.:||.|||||..|..|  ..|.:|.        :.:.|:.|:|.:.:||
  Fly   343 VMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQSLVSELRDEVSRLR 407

  Fly   362 VELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDR---NRKLQQEL 423
            .::|:....|.:..:|..||..|:.....|.|||.|...:.::.|.::|.|:::   ..|.|.:|
  Fly   408 TKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRKTELRYLREQIVLTFKQQMKL 472

  Fly   424 HQSLLDLTEKEMRAHIAEQAHDKLRSH--VSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNR 486
            .:.||     |..:|:.....|..|.|  :|..:.::.:...|.       ||:::.      :.
  Fly   473 RRKLL-----EAESHLLGLELDAERQHMIISHWQGRIGKLYDAM-------GDDDIE------SE 519

  Fly   487 VHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNIN 551
            ..|.|:....||.:...|:|:....|..||         ||:     |:...|.:.
  Fly   520 GSVALKNAWGELAAIEKETRRYKEIRERTE---------HEL-----EQCRQKGVK--------- 561

  Fly   552 RQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEE 616
                |:.||.|||        |.||:.:|.....::.:|||::..|  |...:      |:.||.
  Fly   562 ----LEDELPERI--------SSDEERELLALLCRVHELEADKVSL--QAERL------ARQAEL 606

  Fly   617 RRKRLQLLE--------QEISDLRRKLITQANLLKIRDKERE 650
            ||:.||||.        ::|...:|:||.:.| :.:.|:.||
  Fly   607 RRRDLQLLRAERQRRLCEDIISSQRRLIEEGN-VDLPDELRE 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	136/353 (39%)
		Kinesin	14..335	CDD:278646	134/347 (39%)
		Smc	<396..>994	CDD:224117	63/268 (24%)
		FlaC	522..633	CDD:225888	29/118 (25%)
		TCR	1075..1110	CDD:281618
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	136/352 (39%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	134/347 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840