DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Klp68D

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	227/829 - (27%)
Similarity:	392/829 - (47%)	Gaps:	164/829 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSEDPS-CVAVALRVRPLVQSEL------------DRGCRIAVERSADGAPQVTVNRNESYTYNY 53
            ||:.|: ||.|.:|.||:...|.            :||. :.::...||..:    :.:.:||:.
  Fly    12 SSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGV-VELQNVVDGNKE----QRKVFTYDA 71

  Fly    54 VFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHVGVIPRAV 117
            .:|...:|..|:...|...|..:|.|:|..|.||||||:|||:|| |...|   |:.:|:|||..
  Fly    72 AYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGN---DELMGIIPRTF 133

  Fly   118 HDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTS 182
            ..|:..|...:: |:|.|..|::|:|.|:..||....::.   :::||..:.:.:|.|..:...|
  Fly   134 EQIWLHINRTEN-FQFLVDVSYLEIYMEELRDLLKPNSKH---LEVRERGSGVYVPNLHAINCKS 194

  Fly   183 AQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCS 247
            .:.:...:..|:..|.|..|.|||.||||||||.:.:.....: ..::...:.||:|||||||.|
  Fly   195 VEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTE-TNTIKVGKLNLIDLAGSERQS 258

  Fly   248 KTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACV 312
            ||.||.:|.||...||..|.:|||||:||  .:::.::|||.|||||||||||||||.|:|||.:
  Fly   259 KTGASAERLKEASKINLALSSLGNVISAL--AESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANI 321

  Fly   313 SPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISA 377
            .|::||..|||:|||||.||..|:|:|:.|.||..|::...::.|::|:
  Fly   322 GPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLK---------------- 370

  Fly   378 VGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQ 442
                             .:....:.||.::||...:.|.:|.::|.               :.::
  Fly   371 -----------------RLIGPQQQQRSEKQVTAKKQRVKKPKKET---------------VTKE 403

  Fly   443 AHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQ 507
            ..|.|:  ||.::..::.....:.....::.:||            .|:.::.||||.:..|:.:
  Fly   404 MSDSLQ--VSTIEQPVEDDSDPEGAESESDKENE------------AEVAKSNEELERERVENSK 454

  Fly   508 RLSSRSHTEGGESGGDEVHEMLHSHSE---EYTNKQMNFAGELR---NINRQLDLKQELHERIM- 565
            ..:..:..||....|.:  .:|.::||   |...|.:..|...:   .|.:||:|::|....|.
  Fly   455 LAAKLAELEGQLVRGGK--NLLDTYSERQIELEKKLVEIAERKKREIEIQQQLELQEETTLEIRE 517

  Fly   566 RNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKS---KDI------SAKLAEERRKRL 621
            ||.|.    :::|:|:  .:|:....|:...|..:|.:.||   :|:      ..:|.:|.:::|
  Fly   518 RNVSL----EQEVELK--KRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKELKRQL 576

  Fly   622 QLLEQEIS-DLRRKLITQANLLKIRDKERE--KIQNLS-------------------------TE 658
            .:::..:. :::::|.|||..    |:|:|  |..::|                         |.
  Fly   577 LIIDNFVPIEVKQRLYTQAKY----DEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTS 637

  Fly   659 IRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKC 723
            ...::|:|.....::|.:||....:::......|| :.:..|:.:.:   |.:.::..|......
  Fly   638 EYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQ-EYRTPKVSASL---QAVLAQAMQTGGDDI 698

  Fly   724 EEALAANKRLKDALERQASAQAQRHKYKDNGGS------AAGSSNANAK 766
            :...:....|:..||...:|.|       |||:      |.|||..|.:
  Fly   699 DIVDSHTNSLRSRLENIINANA-------NGGAGPGAGVAVGSSIPNVR 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	133/342 (39%)
		Kinesin	14..335	CDD:278646	130/333 (39%)
		Smc	<396..>994	CDD:224117	82/421 (19%)
		FlaC	522..633	CDD:225888	28/127 (22%)
		TCR	1075..1110	CDD:281618
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	133/340 (39%)
		KISc	20..351	CDD:214526	135/345 (39%)
		GBP_C	<479..576	CDD:303769	24/102 (24%)
		coiled coil	547..558	CDD:293879	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840