Protein Alignment Klp3A and Klp67A

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 854
• Identity: 235/854 - (27%)
• Similarity: 381/854 - (44%)
• Gaps: 188/854 - (22%)

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAV---ERSA--------------DGAPQ----VTVN 44
            |.||..:.:.||:||||....||::..|..:   :|||              .||.|    :|..
  Fly     1 MPSEQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKR 65

  Fly    45 RNESYT--YNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVL 106
            .|:..|  ::.|||||:|.:||||.|....|..:|||||.::..||.||:|||:|| |:
  Fly    66 MNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGS------ 124

  Fly   107 DDHVGVIPRAVHDIFTAIAEMQSEFR-FAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRI 170
            :.|.|:....:.|:|..| :.||:.| |.|..|::|:|.|...:|.:.    ...:.:||..|.:
  Fly   125 EAHPGLTYLTMQDLFDKI-QAQSDVRKFDVGVSYLEVYNEHVMNLLTK----SGPLKLREDNNGV 184

  Fly   171 IMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVAT--KLDGKQSVTTS 233
            ::.||....:.||:::...|:.|::.|....|..|..||||||||.:.:..|  |.|.|::|
  Fly   185 VVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTV--- 246

  Fly   234 RFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQD 298
            :.:::|||||||.:.|...|.|||||.:|||.||||||.||.|..|  ..:||||.|.|||:|:|
  Fly   247 KLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADG--LKHIPYRDSNLTRILKD 309

  Fly   299 SLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVE 363
            |||||..|||:|.||.:.....:|.:||:||.||.:|:.         ..:.|:||
  Fly   310 SLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRT---------TLKQNVLK--------- 356

  Fly   364 LLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSL- 427
                .||                |.|..:.......||.:||||:.:.|:.:..:|::..:...
  Fly   357 ----SKM----------------PTEFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFD 401

  Fly   428 -LDLTEKEMRAHIAEQAHDKLRSHVSELKNKLD--------QREQAQFGN----ENTNGDNEMRD 479
             |:|.....:......|..:|:.||..:::|:.        ::|..:|..    :......:.|.
  Fly   402 PLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRR 466

  Fly   480 FSLLVNRVHVELQRTQEELES---------QGHESRQRLSSRSHTEGGESGGDEVHEML-----H 530
            |:..::.:..::::.:|||.|         |..||.:|..::|          :.:::|     :
  Fly   467 FANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKS----------KAYQILIVYVKY 521

  Fly   531 SHSEEYTNKQMNFAGELRNINRQ----LDLKQELH----ERIMRNFSRLDSDDEDVKLRLCNQKI 587
            ...|....||..|...:..||::    |||.::..    |.:.:.:.||:.          .||:
  Fly   522 KDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLED----------GQKL 576

  Fly   588 -DDLEAERRDLMDQLR------NIKSKDI-----------SAKLAEE--------RRKRLQLLEQ 626
             .::||....|:.::|      |.|..::           ||:..||        .:||.:...|
  Fly   577 TPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQ 641

  Fly   627 EISDLRRKLITQANLLKIRDKEREKIQNLSTEI-RTMKE----SKVKLIRAMRGESEKFRQWKMV 686
            ...||.         |.:.|.:.:..::.|.|: ||.|.    ::.:::......|.........
  Fly   642 SDDDLH---------LSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTSSSSS 697

  Fly   687 REKELTQLKSKDRKMQ----SEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALER---QASAQ 744
            ..|.||...:|.|.:|    |:::..|.:.....::.|    ..|.:|......|:|   .||..
  Fly   698 ARKALTATVTKPRTVQQRLVSDLISDQNVRGGNEKIKK----ALLKSNHFTAQGLQRTLAAASLA 758

  Fly   745 AQRHKYKDN 753
            .:..||..|
  Fly   759 KENVKYNAN 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	140/355 (39%)
		Smc	<453..>985	CDD:440809	70/373 (19%)
		Metallothio	<1071..1115	CDD:395080
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	140/353 (40%)