Protein Alignment Klp3A and Klp61F

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Alignment Length: 1194
• Identity: 304/1194 - (25%)
• Similarity: 510/1194 - (42%)
• Gaps: 295/1194 - (24%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRN-------ESYTYNYVFDIDDSQKDLFE 66
            :.|.:|||||  :..:|..|.|......| |:..|.|:       :.:|::..|..:..|.|::.
  Fly    20 IQVYVRVRPL--NSRERCIRSAEVVDVVG-PREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYS 81

  Fly    67 TCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVL------DDHVGVIPRAVHDIFTAIA 125
            ..|...::::|||||.|:.||||||:|||:||.......|      |..:|:||||:..:|..:.
  Fly    82 VVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELR 146

  Fly   126 EMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATV-DIREVKNRIIMPGLTELVVTSAQQVTDH 189
            .|:.|:...:  |::|||.|:..||.|:....|..: |....|..:|:.||.|:.|.|...|...
  Fly   147 MMEVEYTMRI--SYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKL 209

  Fly   190 LIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK--LDGKQSVTTSRFNLVDLAGSERCSKT-LA 251
            |.:|...|..|.|.||..|||||.:|::.:...:  ::|:..:...:.|||||||||..||. ..
  Fly   210 LEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNE 274

  Fly   252 SGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPAD 316
            .|.|.:|.||||:.||.||.||.||  ...|.::|||:||||||||:||||.:.|.:||.:||..
  Fly   275 KGIRVRETVNINQSLLTLGRVITAL--VDRAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGH 337

  Fly   317 YNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDV---IQKLRVELLSGGKMSSSLISAV 378
            .::.||||||.||.||..|:|||.||  ....:..:||:.   |.||:.:|::
  Fly   338 KDIEETLSTLEYAHRAKNIQNKPEVN--QKLTKKTVLKEYTEEIDKLKRDLMA------------ 388

  Fly   379 GAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQA 443
             |.....|...|...|.:.       ||     |:.:||:|.:::  .||...:.|:      |.
  Fly   389 -ARDKNGIYLAEETYGEIT-------LK-----LESQNRELNEKM--LLLKALKDEL------QN 432

  Fly   444 HDKLRSHVS-ELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQ 507
            .:|:.|.|| .|..|..:.::.:....||.|.      .||..:|..:.:|..:       |.::
  Fly   433 KEKIFSEVSMSLVEKTQELKKTEENLLNTKGT------LLLTKKVLTKTKRRYK-------EKKE 484

  Fly   508 RLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLD 572
            .::|...||          ::|.:.::|..........:...::..::.::||.|:|.|:..:..
  Fly   485 LVASHMKTE----------QVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFK 539

  Fly   573 SDDEDVKLRLCNQKIDDLEAERRDLMDQLRN--IKSKDISAKLAEERRKRLQLLE-------QEI 628
            ...:| .|.:....::..:.::..|.:||..  :.|..:|.:||....|.:::|:       |:.
  Fly   540 DRMQD-NLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQ 603

  Fly   629 SDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQ 693
            ::|..|||  ..::||.|:                            .|:.|
  Fly   604 TNLHNKLI--GEVMKISDQ----------------------------HSQAF------------- 625

  Fly   694 LKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAA 758
                ..|:..::.:||.|.||:.|...:..||....:|.:.|:::         .|:.....|:.
  Fly   626 ----VAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQ---------EKFATIIDSSL 677

  Fly   759 GSSNANAKTDSWVDRELEII--LSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQAR 821
            .|...:||.   :.::||.:  :||.||| .|:.|.|:.|   |...|.|||.
  Fly   678 QSVEEHAKQ---MHKKLEQLGAMSLPDAE-ELQNLQEELA---NERALAQQED------------ 723

  Fly   822 ILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQAS 886
               :|.|.:.|:..||.:|:                            ||..:...|...:::.|
  Fly   724 ---ALLESMMMQMEQIKNLR----------------------------SKNSISMSVHLNKMEES 757

  Fly   887 SLNEQRTTLDELRAQLLDAQQQEDAASKRLRL-LQSQHEEQMLA--QQRAYEEKVSVLIRTANQR 948
            .|.... .:|::::.:.|.|:....||:..:. |.||.|..||.  |..|....:.|.::..||:
  Fly   758 RLTRNH-RIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQK 821

  Fly   949 W----------------------AEARSPAED-QQRNQI-LEELLSSREALQQE----------- 978
            :                      .|::...|. |::.:: ||:::.:|:.|..|
  Fly   822 YEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATV 886

  Fly   979 -LDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDPDWVPS-TSKSKRIQSDSRNV 1041
             .|.::..|:..|:..:.:.|.|    ||.:  :.:|....|:...:.|: |:.|||.....|.:
  Fly   887 ATDLVQESNRQFSEHAEHQRQQL----QICE--QELVRFQQSELKTYAPTGTTPSKRDFVYPRTL 945

  Fly  1042 I--SPPE------KQDANVTSLGNS-------------SIQSLNSTSATE-----------DGKR 1074
            :  ||.:      :|:.:.:.|..:             |:.|:...|.||           ||
  Fly   946 VATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDG-- 1008

  Fly  1075 CKGCKCRTKCTTKR-CGCLSGNNA 1097
                     .|.|| ||....:|:
  Fly  1009 ---------VTVKRGCGTTRNSNS 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	134/343 (39%)
		Smc	<453..>985	CDD:440809	109/581 (19%)
		Metallothio	<1071..1115	CDD:395080	8/28 (29%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	140/353 (40%)
		SMC_prok_B	<408..728	CDD:274008	87/434 (20%)
		SMC_prok_B	<651..>921	CDD:274008	68/335 (20%)
		Microtub_bind	923..>1004	CDD:464048	15/80 (19%)