Protein Alignment Klp3A and KIF5C

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_004513.1
• Gene: KIF5C / 3800
• HGNCID: 6325
• Length: 957
• Species: Homo sapiens
• Alignment Length: 1072
• Identity: 302/1072 - (28%)
• Similarity: 484/1072 - (45%)
• Gaps: 246/1072 - (22%)

  Fly     5 DPS-C-VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFET 67
            ||: | :.|..|.|||.::|:.||.:...:...|  ..|.:.:.:.|.::.|...:.:|:.::..
Human     3 DPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGD--ETVVIGQGKPYVFDRVLPPNTTQEQVYNA 65

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH--VGVIPRAVHDIFTAIAEMQSE 130
            |.:..||.:|.|||.||.|||||.||||:||    .|.|.|.  :|:|||..||||..|..|...
Human    66 CAKQIVKDVLEGYNGTIFAYGQTSSGKTHTM----EGKLHDPQLMGIIPRIAHDIFDHIYSMDEN 126

  Fly   131 FRFAVTCSFVELYQEQFYDLFS-SKTRDKATVDIREVKNRI-IMPGLTELVVTSAQQVTDHLIRG 193
            ..|.:..|:.|:|.::..||.. |||    .:.:.|.|||: .:.|.||..|:|.::|.|.:..|
Human   127 LEFHIKVSYFEIYLDKIRDLLDVSKT----NLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEG 187

  Fly   194 SAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKE 258
            .|.|.||.|.|||.|||||:||.:.:....::.::.: :.:..||||||||:.|||.|.|....|
Human   188 KANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKL-SGKLYLVDLAGSEKVSKTGAEGAVLDE 251

  Fly   259 GVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETL 323
            ..||||.|.||||||:||..|... ::|||.||:||:||||||||..|.::.|.||:.:|.|||.
Human   252 AKNINKSLSALGNVISALAEGTKT-HVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETK 315

  Fly   324 STLRYADRALQIKNKPVVNLDPHAAE-----------VNMLKDVIQKLRVEL---LSGGKM-SSS 373
            |||.:..||..|||...|||:..|.|           ...||:|||.|.:||   .:|..: ...
Human   316 STLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDE 380

  Fly   374 LISAVGAAGLGAIPCE-----ESLAGSMA--NAAEIQRLKEQV----RTLQDRNRKLQQE----- 422
            .|||.....|.  ||:     :::|..:|  :..|.::..|::    |.|.|::.::.|:
Human   381 QISAKDQKNLE--PCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAE 443

  Fly   423 -LHQSLLD--------------LTEKEMRAHIA-EQAHDKLR---SHVSELKNKLDQREQAQFGN 468
             |.|.:||              :.|:..|..|. |.|.|:::   ..:.||....||:.|..  .
Human   444 KLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEV--E 506

  Fly   469 ENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRSHTE------------GGESG 521
            :.|..:.::.|  .|..:. ..|..||.|| ||..|.......|: ||            ||..|
Human   507 DKTRANEQLTD--ELAQKT-TTLTTTQREL-SQLQELSNHQKKRA-TEILNLLLKDLGEIGGIIG 566

  Fly   522 GDEVHEMLHSH---SEEYT------NKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDED 577
            .::|..:...:   .||:|      :|..:....|.|.::||:..|....|.|....|
Human   567 TNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASER------- 624

  Fly   578 VKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANL- 641
             :|..|...|...||:.:.|.|.::|:          |::|::|:..:..:|:...||..|..:
Human   625 -ELAACQLLISQHEAKIKSLTDYMQNM----------EQKRRQLEESQDSLSEELAKLRAQEKMH 678

  Fly   642 -LKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEI 705
             :..:|||:|.:    |.::..:|.|    :|:..:.|..|:   ..:|:|::|:.:
Human   679 EVSFQDKEKEHL----TRLQDAEEMK----KALEQQMESHRE---AHQKQLSRLRDE-------- 724

  Fly   706 VRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQ-ASAQAQRHKYKDNGGSAAGSSNANAKTDS 769
                 :..||:.:     :|....|::|:  ||:: .|:...:.|.:|.
Human   725 -----IEEKQKII-----DEIRDLNQKLQ--LEQEKLSSDYNKLKIEDQ---------------- 761

  Fly   770 WVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQAR-ILASLEEELEMR 833
              :||::           ||:|:           ||..::        |||| .|..|||.:. |
Human   762 --EREMK-----------LEKLL-----------LLNDKR--------EQAREDLKGLEETVS-R 793

  Fly   834 NAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQ--RTTLD 896
            ..|.....:|:...||.:|::...|.....|......||.: :.::....|.:.:::|  |...|
Human   794 ELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKI-SFLENNLEQLTKVHKQLVRDNAD 857

  Fly   897 ELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQR 961
             ||.:|...:::..|.::|::.|:|..:|..
Human   858 -LRCELPKLEKRLRATAERVKALESALKEAK---------------------------------- 887

  Fly   962 NQILEELLSSREALQQELDKL----RAKNKSK 989
                |..:..|:..|||:|::    ||||.::
Human   888 ----ENAMRDRKRYQQEVDRIKEAVRAKNMAR 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	139/334 (42%)
		Smc	<453..>985	CDD:440809	117/562 (21%)
		Metallothio	<1071..1115	CDD:395080
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	139/332 (42%)
		Microtubule-binding	174..315		70/142 (49%)
		PRK03918	<412..907	CDD:235175	132/639 (21%)
		Khc_CBD_cc	836..905	CDD:467880	18/107 (17%)
		Globular	859..956		17/95 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..957		2/5 (40%)