Protein Alignment Klp3A and cana

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Alignment Length: 1582
• Identity: 333/1582 - (21%)
• Similarity: 570/1582 - (36%)
• Gaps: 512/1582 - (32%)

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLF 65
            ||:::.|.:.|.::||| .:..|....::...||.    |:..:..|.|.::||||...|.:::|
  Fly     1 MSTKNASSIQVCIKVRP-CEPGLTSLWQVKEGRSI----QLADSHAEPYVFDYVFDEGASNQEVF 60

  Fly    66 ETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDIFTAIAEMQS 129
            :...:..|...:.|.|.||.|||||.|||||| ||.      :.:.||:..|..:||..|:. ::
  Fly    61 DRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGD------EQNPGVMVLAAKEIFQQISS-ET 118

  Fly   130 EFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVTDHLIRGS 194
            |..|.:...::|:|.|:.|||.:.|.:|   :.|.|..|.|:.....|.:|||...:...|..|:
  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNKKNQD---LKIHESGNGIVNVNCKESIVTSEDDLLRQLYMGN 180

  Fly   195 AGRAVAATAMNETSSRSHAIFTLTLVATKLD--GKQSVTTSRFNLVDLAGSERCSKTLASGDRFK 257
            ..|.|..|.|||.||||||||.:.:.:.|.|  ...:|..|..:||||||||:.
  Fly   181 KERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQV----------- 234

  Fly   258 EGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAET 322
            :..:....|:...|::.:|.....:....:|.|||.|::..|||||.:|.:|..::|:  .|.|:
  Fly   235 DPADHASSLMIFRNLVKSLSESVDSKPNSFRDSKLPRIMLPSLGGNVLTSIICTITPS--FVEES 297

  Fly   323 LSTLRYADRALQIKNKP-VVNLDPHAA-------EVNMLKDVIQKLRVELLS-------GGKMSS 372
            .||:.:...|.:|:.|| |..:|....       .::||||.:.|.:::..|       .|::..
  Fly   298 SSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKKKIKNESQLVLQELEGRIKR 362

  Fly   373 SLISAVGAAGLG-------------------------AIP------------------------- 387
            .::..|.:|.|.                         |:|
  Fly   363 DMLKIVSSASLDDYRLQKRRRTWTLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPKPLFQRRG 427

  Fly   388 -------------------------------------------------------CE------ES 391
                                                                   |:      .:
  Fly   428 IAPKAKGICKTLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEISA 492

  Fly   392 LAGSMANAAE-IQRLKEQVRTLQDRNRKLQQE--------------------------------- 422
            |..|...|.| |::.:|||:.|::...:|:.|
  Fly   493 LTASNQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSSISEKD 557

  Fly   423 -----LHQSLLDLT--------EKEMRAHIAEQ-------------------------------A 443
                 |.|||.:|:        |.:||:...|.                               .
  Fly   558 STIVSLQQSLEELSRDVLRNSKEDQMRSMCPELESSCERICNKCLELERLLPLASASGLDSVACQ 622

  Fly   444 HDKLRSHVSELKNKLDQ----------------------REQA-----QFG--NENTNG------ 473
            .|:|||.::..:.||:.                      .||.     .||  .|..|.
  Fly   623 FDQLRSEIAATRMKLESMLSTFSHASCEVSQKTTDCKRLSEQISTAHDDFGQLQEKYNNLKHKWS 687

  Fly   474 ------DNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRSHTEGGESGG-----DEVH- 526
                  |....|:: .:.:.:::||.....||.:..|..|:|...:.....|.|.     :|:|
  Fly   688 SQKLAIDTMQVDYN-TIQQKYLQLQDEYRHLELRSDEQCQQLQDENSKLQAEIGTLKERVEEIHS 751

  Fly   527 EMLH-----SHSE------------------EYTNKQMNF---AGELRNINRQLDLKQELHERIM 565
            |:|.     :|.|                  |:...|:|:   :.||.:..::.|..:|.|::..
  Fly   752 ELLEVPNPDTHPEDMELQNQELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRT 816

  Fly   566 RNFSRLDSDDEDVKLRLCNQKIDDLEAE-RRDLMDQLRNIKSKDI-------------------- 609
            .|     ||.|.:|......:..|.|.| ..||:.|...: ||.|
  Fly   817 TN-----SDLESMKSSGVGTECSDPENELDTDLLQQFTKL-SKSIQQIELTDYSGGRRLFIYNHA 875

  Fly   610 -------SAKLAEERRKRLQ--LLEQEISD---------LRR----KLITQANLLKIRDKEREKI 652
                   |.||..|..|.|:  ..:.:.||         .:|    |:..:.||:|..|:.|:.|
  Fly   876 EQDQSVPSLKLCLEPAKYLEGDGKQHDASDSVFLKGFLKCQRFQIVKINQEQNLVKEEDRMRDII 940

  Fly   653 QNLSTEI---RTMKESKVKLIRAMRGESEKFRQWKMVREKE------LTQLKSKD-----RKMQS 703
            ..|..|:   :.:.|.:.::|..:|.:.....|.:.::.:.      ..:|::||     .|.:|
  Fly   941 FQLKQEVDGKKNLIEEEKEVINNLRAQITSLNQIETIKNQNAKTKILCEELQTKDTVQTANKQES 1005

  Fly   704 EIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTD 768
            :.|  .||.:....:..:.||        |:..||:|:..:.......|.|..:....:...|..
  Fly  1006 QEV--LTLKTSLAHLKSKVCE--------LQKKLEKQSEDEKISELQSDIGEISECCLSMELKLA 1060

  Fly   769 ---SWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQ---------QEKTSDPAEAAEQAR 821
               :|...||          ..|:||.|....:.:|....:         ||:| :.....|..|
  Fly  1061 DIVNWQAEEL----------RPLDQLQESGVELQHHSTTAEESLNVEKPIQEQT-ERTLTTEYER 1114

  Fly   822 ILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQAS 886
            .:..|||.|:....::|.|:::....:...::..:|:...|..|:|:..:.....|.:.::....
  Fly  1115 RIEQLEESLQRAQEELSILEKRKTDENKSLQLEYMAKIETSENENRSKFRAYCLDLKETQKRYEE 1179

  Fly   887 SLNEQRTTLDELRAQLLDAQQQEDAASKRL--RLLQSQHEEQMLA-QQRAYEEKVSVLIRTANQR 948
            .|.:   |.::|.:.....|...|...:.|  ::.|::.|...|| :.:|..||:...::.....
  Fly  1180 QLQQ---TNEKLASVTTQCQVHLDVIKRSLQEKITQAEKERNELAVRHKAELEKIRETLKEKESS 1241

  Fly   949 WAEARSPAEDQQ----------RNQI--LEELLSSREALQQ------------------ELDKLR 983
            :.|....||:::          ||.|  |.:..|.||...:                  ||::|:
  Fly  1242 YKEKLRQAEEERDKEISRLEVMRNTIAELHKTNSDREVELEGVKMEKCQLKKLYDKSMLELEQLQ 1306

  Fly   984 --AKNKSKSKAVKSEPQDLDD----------SFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQS 1036
              |..||......|..:::||          ..:::.|.:..:||::             ::|..
  Fly  1307 CTADQKSSDLLPGSSNENIDDLQKKCDQYVQDLELLRGEKAELLSEI-------------QKING 1358

  Fly  1037 DSRNVISPPEKQDANVTSLGN----------SSIQSLNSTSATEDGKRCKGCK-------CRTKC 1084
            ...|.|...|:.:|.:.:|..          ..:::..|..|  |.|....|.       .:..|
  Fly  1359 QHSNTIKKLEEIEAEMITLTTQKELERCEIAEKLETFKSKEA--DIKEALHCAQLRLHAYDKLVC 1421

  Fly  1085 TTKRC-GCLSGNNACSETCVCKSNCRNPLNLKD-----HASQCG--DG-DGQKDETEDADKSDDD 1140
            ..:|. ||||.:|..||            ||:.     ||.|..  :| .|:..|.:.......|
  Fly  1422 EYERLKGCLSDSNKLSE------------NLQKKVERLHAEQLALQEGISGRDSEIKQLRSELKD 1474

  Fly  1141 GDDEPQTSK------ENAVKFV 1156
            ..||.:|.:      ||::|.|
  Fly  1475 AIDENKTVREAKVGLENSLKAV 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	108/331 (33%)
		Smc	<453..>985	CDD:440809	136/708 (19%)
		Metallothio	<1071..1115	CDD:395080	13/51 (25%)
cana	NP_001027247.1	Motor_domain	8..310	CDD:473979	107/329 (33%)
		CCDC158	<505..>729	CDD:464943	35/224 (16%)
		SMC_prok_B	622..1285	CDD:274008	137/693 (20%)
		SMC_prok_B	1110..1875	CDD:274008	84/417 (20%)