Protein Alignment Klp3A and KIF7

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_011519833.1
• Gene: KIF7 / 374654
• HGNCID: 30497
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 1323
• Identity: 335/1323 - (25%)
• Similarity: 560/1323 - (42%)
• Gaps: 340/1323 - (25%)

  Fly     2 SSEDPSCVAVALRVRPLVQSELDRG---CRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKD 63
            :.|.|  |.||||||||:..||..|   | :.||   .|..:||:.|:..:.::.|...|..|:.
Human    52 AEEAP--VRVALRVRPLLPKELLHGHQSC-LQVE---PGLGRVTLGRDRHFGFHVVLAEDAGQEA 110

  Fly    64 LFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTA-FNGVLDDHVGVIPRAVHDIFTAIAEM 127
            :::.|||..::....|:|.|:.||||||||||||||.| ...:|:|..|::|||:.:.|..|.|
Human   111 VYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLLEDEQGIVPRAMAEAFKLIDE- 174

  Fly   128 QSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLI 191
            .......|..|::|:|:|:|.||....|..: .:.:|| .:..:::.|:.|:.|....:|...|.
Human   175 NDLLDCLVHVSYLEVYKEEFRDLLEVGTASR-DIQLREDERGNVVLCGVKEVDVEGLDEVLSLLE 238

  Fly   192 RGSAGRAVAATAMNETSSRSHAIFTLTL-----VATKL--DGKQSVTTSRFNLVDLAGSERCSKT 249
            .|:|.|...||.:|..|||||.:||:||     ..::|  .....:..|:|:.||||||||..||
Human   239 MGNAARHTGATHLNHLSSRSHTVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHFVDLAGSERVLKT 303

  Fly   250 LASGDRFKEGVNINKGLLALGNVINALGSGQAAG-YIPYRQSKLTRLLQDSLGGNSITLMIACVS 313
            .::|:|.||.:.||..||||||||:|||..|..| :||||.||:||:|:||||||:.|:||||||
Human   304 GSTGERLKESIQINSSLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVS 368

  Fly   314 PADYNVAETLSTLRYADRALQIKNKPVVNLDPHA------------------------------- 347
            |:..:..|||:||.||.||..|:|:..||..|.|
Human   369 PSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERPPEETASGARGPPRHRSETRIIHRGRRAP 433

  Fly   348 -------------------------AEVNMLKDV----------IQKLRVELLSGGKMSSSLISA 377
                                     |..::|:::          .:|:|..|.:.....|:|.||
Human   434 GPATASAAAAMRLGAECARYRACTDAAYSLLRELQAEPGLPGAAARKVRDWLCAVEGERSALSSA 498

  Fly   378 VGA-AGLGAIPCEESLAGSMA------NAAEIQRLKEQVRTLQDRNR-------------KLQQE 422
            .|. :|:.:...|:..|....      .|.::..|:.||..|::.||             |||.:
Human   499 SGPDSGIESASVEDQAAQGAGGRKEDEGAQQLLTLQNQVARLEEENRDFLAALEDAMEQYKLQSD 563

  Fly   423 -LHQSLLDLTEKEMRAHIAEQ---------------------------AHDKLRSHVSELKNKLD 459
             |.:...::.|..:|..:...                           ||..:...|.......|
Human   564 RLREQQEEMVELRLRLELVRPGWGGPRLLNGLPPGSFVPRPHTAPLGGAHAHVLGMVPPACLPGD 628

  Fly   460 QREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQG-------HESRQRLSSRSHTEG 517
            :....|.|.:.|||.....:....|||:........||.|.:.       |..|.|:|:.|...|
Human   629 EVGSEQRGEQVTNGREAGAELLTEVNRLGSGSSAASEEEEEEEEPPRRTLHLRRNRISNCSQRAG 693

  Fly   518 GESG------GDEV------------------------HEMLHSHSEEYTNKQMNFAGELRNINR 552
            ...|      |.|:                        .::..:.:.|:...|..  .::|.:..
Human   694 ARPGSLPERKGPELCLEELDAAIPGSRAVGGSKARVQARQVPPATASEWRLAQAQ--QKIRELAI 756

  Fly   553 QLDLKQELHERIMRN------FSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDIS- 610
            .:.:|:||...::|.      .:|..|.    ::|...|:.:.:.||..:...|||.::.|::.
Human   757 NIRMKEELIGELVRTGKAAQALNRQHSQ----RIRELEQEAEQVRAELSEGQRQLRELEGKELQD 817

  Fly   611 ----AKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIR 671
                ::| :|.|:|:...:.::..|:.|......|:.:..:..:::|.|...::.|::.:.:|.|
Human   818 AGERSRL-QEFRRRVAAAQSQVQVLKEKKQATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQR 881

  Fly   672 AMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKD- 735
            .:|.|:|:.|           :|:::..|.|..:...:..|.:|:::||.|.||..|..::.:.
Human   882 RLREETEQKR-----------RLEAEMSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSG 935

  Fly   736 ------ALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMED 794
                  :||:|...:.|:                     .|:|:|:|.:|   ....:||:|.|:
Human   936 SNGSVVSLEQQQKIEEQK---------------------KWLDQEMEKVL---QQRRALEELGEE 976

  Fly   795 ---RAVINNHYHLLQQEKT--------SDPAEAAEQARI---LASLEEELEMRNAQ--------- 836
               |..|......|.||||        |..|...:..|:   |..||:||..::.|
Human   977 LHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQSQ 1041

  Fly   837 ------ISDLQQK--------------------VCPTD------LDSRIRSLAEGVQSLGESRTV 869
                  |..|:|:                    :.|.:      ||..|.:|...::...|:.|.
Human  1042 QQIRGEIDSLRQEKDSLLKQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITC 1106

  Fly   870 SKQLLK---TLVQQ------RRLQASSLNEQRTTL---------------------DELRAQLLD 904
            .:::|:   :|:.|      .:|...|.:|.|..|                     .||..||.:
Human  1107 RQRVLRASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEE 1171

  Fly   905 AQQQE---DAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAE--ARSPAEDQQRNQI 964
            .|:..   :.|.:|.||   :.:.|:..||:.:|:.:.:|::.:.....|  |.|..:.:.|.|.
Human  1172 QQRLVYWLEVALERQRL---EMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQYEARIQA 1233

  Fly   965 LEELLSS----REALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDPD-- 1023
            ||:.|..    .:.|:|:|..:.|...|:.    .|.:.|....:...|||    .::...|:
Human  1234 LEKELGRYMWINQELKQKLGGVNAVGHSRG----GEKRSLCSEGRQAPGNE----DELHLAPELL 1290

  Fly  1024 WV-PSTSKSKRIQSDSRNVISPP 1045
            |: |.|..:.|.:.::|:::..|
Human  1291 WLSPLTEGAPRTREETRDLVHAP 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	147/341 (43%)
		Smc	<453..>985	CDD:440809	137/680 (20%)
		Metallothio	<1071..1115	CDD:395080
KIF7	XP_011519833.1	KISc_KIF4	56..391	CDD:276823	148/342 (43%)
		Smc	<743..>1239	CDD:440809	111/540 (21%)