Protein Alignment Klp3A and unc-104

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 1275
• Identity: 320/1275 - (25%)
• Similarity: 499/1275 - (39%)
• Gaps: 352/1275 - (27%)

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGA------PQVTVNRNES---YTYNYVF------D 56
            |.|.||:||||....|:.|..:..:|.:  ||      |:|..|.::|   :.::|.:      |
  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMA--GATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHD 64

  Fly    57 IDDS-----QKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRA 116
            .|.|     .||:.|..:|..    .:||||.|.||||||:||:|||   .....:...|:||..
  Fly    65 ADFSTQSMVYKDIGEEMLQHS----FDGYNVCIFAYGQTGAGKSYTM---MGRQEEQQEGIIPMI 122

  Fly   117 VHDIFTAIAEMQS-EFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTE 177
            ..|:||.|.:.:: :.:::|..|::|:|.|:..||.:.|  :|..:.:||  :.::.|   .|::
  Fly   123 CKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK--NKGNLRVRE--HPLLGPYVEDLSK 183

  Fly   178 LVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTT---SRFNLVD 239
            |.||..|.:.|.:..|:..|.||||.||||||||||:||:.....:.|...::||   |:.:|||
  Fly   184 LAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVD 248

  Fly   240 LAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-------SGQAAGYIPYRQSKLTRLLQ 297
            ||||||...|.|.|.|.|||.||||.|..||.||:||.       :.:.|.:||||.|.||.||:
  Fly   249 LAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLR 313

  Fly   298 DSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRV 362
            ::|||||.|.|||.:||||.|..||||||||||||.||..|.|||.|.:|..:..||:.|||||
  Fly   314 ENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLR- 377

  Fly   363 ELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSL 427
            :||.                              |...|:|...|..::...::....:..:.|.
  Fly   378 DLLK------------------------------AEGIEVQEEDELTKSTVIKSPTKSRNRNGST 412

  Fly   428 LDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQ 492
            .::...::      ||.:||   ::||....:::                             |:
  Fly   413 TEMAVDQL------QASEKL---IAELNETWEEK-----------------------------LK 439

  Fly   493 RTQE---ELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQL 554
            ||:|   :.|:...|....:.....|.|..|.....|                    |.|:|...
  Fly   440 RTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPH--------------------LVNLNEDP 484

  Fly   555 DLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEER-- 617
            :|.:.|...|....:||.:.:.:|.        .|::.....::.:....::|:.:..|...:
  Fly   485 NLSECLLYYIKEGLTRLGTHEANVP--------QDIQLSGSHILKEHCTFENKNSTVTLLPHKDA 541

  Fly   618 ------RKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGE 676
                  ||   |:|.|:.....::|...|.: .|....|:.:.|..:|.|..|::        .|
  Fly   542 IIYVNGRK---LVEPEVLKTGSRVILGKNHV-FRFTNPEQARELRDKIETENEAE--------NE 594

  Fly   677 SEK---------FRQWKMVREKELTQLKSKDRKMQSEIVRQ---QTLHSKQRQVLKRKCEEALAA 729
            .||         |.|.::: ||:...||::.:|....:..|   :.|.:.|:...:||..||
  Fly   595 VEKTDTQQVDWNFAQCELL-EKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEA--- 655

  Fly   730 NKRLKDALERQASAQAQR------------HKYKD--------------NGGSAAGSSNANAKTD 768
              |: |||::|...|:..            |:.:|              ..|.||
  Fly   656 --RI-DALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAA---------- 707

  Fly   769 SWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMR 833
             |..|:...        |....|.:|  :..|...|            .|...|...|:::::.:
  Fly   708 -WAFRKWRY--------HQFTSLRDD--LWGNAIFL------------KEANAISVELKKKVQFQ 749

  Fly   834 NAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDEL 898
            ...::|......|.:|.|.:..:.:      |....:..:.||||........:......:|::|
  Fly   750 FTLLTDTLYSPLPPELASTVAPVHQ------EDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKL 808

  Fly   899 RAQLLDAQQQEDAASKRLRLL---------------QSQHEEQMLAQQRAYEEKVSVLIRTANQR 948
            |.:|...:|..:..|....:|               .|||..|. ||....|
  Fly   809 RYRLELMRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQ-AQLLPLE------------- 859

  Fly   949 WAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQ-------------DL 1000
                 .|.|.::....|..|:.||    |.|:.:|....::::...:.|.             |.
  Fly   860 -----PPVESERGRLTLANLIPSR----QRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDR 915

  Fly  1001 DDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRI--QSDSRNV--ISPPEKQDANVTSLGNSSIQ 1061
            ...|::| |...:.||::...   ||...|...:  :.|.|..  |:.....|.......|...|
  Fly   916 FPWFRMV-GRSFIYLSNLLYP---VPLVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQ 976

  Fly  1062 SLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQCGDG-- 1124
            |.......:|.|.    |.|.                             ||.||...:..|.
  Fly   977 SARLVFNEDDAKP----KYRA-----------------------------LNEKDDVQRYIDNGG 1008

  Fly  1125 -DGQKDETEDADKSDDDGDDEPQTSKENAVKFVTPEAPGK 1163
             |.:.:|.||.|.......:......||:      |.||:
  Fly  1009 LDSKLEELEDVDSGRGIDSNSASECHENS------EEPGE 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	152/362 (42%)
		Smc	<453..>985	CDD:440809	107/595 (18%)
		Metallothio	<1071..1115	CDD:395080	6/43 (14%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	155/368 (42%)
		Kinesin_assoc	355..498	CDD:465047	41/231 (18%)
		FHA_KIF1	474..574	CDD:438757	21/131 (16%)
		YhaN	<575..>666	CDD:443752	27/105 (26%)
		KIF1B	878..924	CDD:463574	8/50 (16%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939