Protein Alignment Klp3A and Khc

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 1046
• Identity: 276/1046 - (26%)
• Similarity: 468/1046 - (44%)
• Gaps: 209/1046 - (19%)

  Fly     3 SEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFET 67
            :||  .:.|..|.|||..||...|.:..|:...:..........:.|.::.||..:.||:.::..
  Fly     9 AED--SIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNE 71

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHV--GVIPRAVHDIFTAIAEMQSE 130
            ..::.|..:|.|||.||.|||||.||||:||    .||:.|.|  |:|||.|:|||..|..|:..
  Fly    72 AAKSIVTDVLAGYNGTIFAYGQTSSGKTHTM----EGVIGDSVKQGIIPRIVNDIFNHIYAMEVN 132

  Fly   131 FRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRI-IMPGLTELVVTSAQQVTDHLIRGS 194
            ..|.:..|:.|:|.::..||...   .|..:.:.|.|||: .:.|.||..|:|.:.|.:.:..|.
  Fly   133 LEFHIKVSYYEIYMDKIRDLLDV---SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGK 194

  Fly   195 AGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEG 259
            :.|.:|.|.|||.|||||::|.:.:....|:.::.: :.:..||||||||:.|||.|.|....|.
  Fly   195 SNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKL-SGKLYLVDLAGSEKVSKTGAEGTVLDEA 258

  Fly   260 VNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLS 324
            .||||.|.||||||:||..|... :||||.|||||:||:|||||:.|.::.|.|||.:|.:||.|
  Fly   259 KNINKSLSALGNVISALADGNKT-HIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKS 322

  Fly   325 TLRYADRALQIKNKPVVNLDPHAAEVN-----------MLKDVIQKLRVELL---SGGKMSS--- 372
            ||.:..||..:||...||.:..|.|..           .||..::||.:||.   :|..:.:
  Fly   323 TLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQ 387

  Fly   373 ----SLISA------VGAAGLGAIPCEESLAG---SMANAAEIQRLKEQVRTLQDRNRKLQQELH 424
                .|:.|      |.||...|  .|.:||.   ::||.:....:.||.|...:..|..||
  Fly   388 INMEDLMEASTPNLEVEAAQTAA--AEAALAAQRTALANMSASVAVNEQARLATECERLYQQ--- 447

  Fly   425 QSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHV 489
                 |.:|:...:...|..::|:..|.|.:..:               .|..|::..|.:
  Fly   448 -----LDDKDEEINQQSQYAEQLKEQVMEQEELI---------------ANARREYETLQS---- 488

  Fly   490 ELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSE---EYTNKQMNFAGELRNIN 551
            |:.|.|:|                    .||..:||.|:|.:..|   .|..|..    |:.|.|
  Fly   489 EMARIQQE--------------------NESAKEEVKEVLQALEELAVNYDQKSQ----EIDNKN 529

  Fly   552 RQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEA-ERRDLMDQLRNIKSKDISAKLAE 615
            :.:|   .|:|.:.:..|..::...::      |::.|:.: :::.:.:.|.|: .:|:.
  Fly   530 KDID---ALNEELQQKQSVFNAASTEL------QQLKDMSSHQKKRITEMLTNL-LRDLG----- 579

  Fly   616 ERRKRLQLLEQEISDLRRKLITQANLLKIRD---KEREKIQNLSTEIRTMKESKVKLIRAMRGES 677
            |..:.:...|..| ||:...:...:..|:.:   ..|..|..:.||.:.:.:....:.......:
  Fly   580 EVGQAIAPGESSI-DLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSN 643

  Fly   678 EKFRQWKMVREKELTQ----LKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDAL- 737
            :|..::    ||:|.:    :...:.:|:|   .|:::...:.:  ||..||.:       |:|
  Fly   644 KKISEY----EKDLGEYRLLISQHEARMKS---LQESMREAENK--KRTLEEQI-------DSLR 692

  Fly   738 ERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVD-------RELEIILSLIDA-EHSLEQLMED 794
            |..|..:|..|....|......:....:..||.:|       |::..:...|.| :|.::::.:
  Fly   693 EECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKD- 756

  Fly   795 RAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEG 859
               ::....|..|:.|:|    .|:.|     :|:.|    :.|:||..:...:...:.|...:|
  Fly   757 ---VHQKLLLAHQQMTAD----YEKVR-----QEDAE----KSSELQNIILTNERREQARKDLKG 805

  Fly   860 VQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHE 924
            ::.     ||:|: |:||...|:|....|.::      :|..:::.:.:||..|
  Fly   806 LED-----TVAKE-LQTLHNLRKLFVQDLQQR------IRKNVVNEESEEDGGS----------- 847

  Fly   925 EQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSK 989
               |||    ::|:|.|....:             |..::.::|:.....|:.||.||..:.:..
  Fly   848 ---LAQ----KQKISFLENNLD-------------QLTKVHKQLVRDNADLRCELPKLEKRLRCT 892

  Fly   990 SKAVKS 995
            .:.||:
  Fly   893 MERVKA 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	134/331 (40%)
		Smc	<453..>985	CDD:440809	103/551 (19%)
		Metallothio	<1071..1115	CDD:395080
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	136/333 (41%)
		Smc	<341..>807	CDD:440809	108/567 (19%)
		Khc_CBD_cc	856..925	CDD:467880	10/56 (18%)