Protein Alignment Klp3A and Cenpe

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_063138291.1
• Gene: Cenpe / 362044
• RGDID: 1307115
• Length: 2505
• Species: Rattus norvegicus
• Alignment Length: 1415
• Identity: 345/1415 - (24%)
• Similarity: 574/1415 - (40%)
• Gaps: 331/1415 - (23%)

  Fly     5 DPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCV 69
            :.:.|||.:|||||...|.:.|....:....|.......:..:|:.::.||..:::.|:::|...
  Rat     3 EEAAVAVCVRVRPLNSREEELGEASHIYWKTDKNAIYQSDGGKSFQFDRVFHSNETTKNVYEEIA 67

  Fly    70 QAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRF 133
            ...:...:.|||.||.|||||.||||:| ||:      :|.:||||||:||||..|.:. .|..|
  Rat    68 VPIISSAIQGYNGTIFAYGQTASGKTHTMMGS------EDCLGVIPRAIHDIFQRIKKF-PEREF 125

  Fly   134 AVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRA 198
            .:..|::|:|.|...||..:..:.|..:...::...:.:..|||.||.:|:.....|..|...|.
  Rat   126 LLRVSYMEIYNETITDLLCNTQKVKPLIIREDINRNVYVADLTEEVVYTAEMALKWLATGEKNRH 190

  Fly   199 VAATAMNETSSRSHAIFTLTL------VATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFK 257
            ...|.||:.|||||.||.:.|      .::..||  |:..|..||||||||||.::|.|.|.|.|
  Rat   191 YGITKMNQRSSRSHTIFRMILESREKAESSNCDG--SIKVSHLNLVDLAGSERAAQTGAEGMRLK 253

  Fly   258 EGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAET 322
            ||..||:.||.||.||..|..||..|:|.||.|||||:||:|||||:.|.:|..::||  ::.||
  Rat   254 EGCYINRNLLILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPA--SLDET 316

  Fly   323 LSTLRYADRALQIKNKPVVN------------------LDPHAAEVNML---------------- 353
            |:||::|..|..:||.|.||                  |.....|||..
  Rat   317 LTTLQFASTAKYMKNTPYVNEVSNDEALLKRYRREIVDLKKQLEEVNTKTRAQEIEKDQLAQLLD 381

  Fly   354 -KDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLA-----------GSMANAAEIQRLK 406
             ||::||::.|.:.  .:...|:::      .:|..::.|.           |.|.::..::..|
  Rat   382 EKDLLQKVQDEKIQ--NLKRMLVTS------SSIALQQELEIKKKRRVTWCFGKMKDSNYVKEFK 438

  Fly   407 EQVRTLQDRNRKL--------------------QQELHQSLLD-LTEKEMRAHIAEQAHDKLRSH 450
            ... .:..|.||.                    :.|:..:.|: |.|.|..:..|..:.:.|.|.
  Rat   439 IPT-NITTRTRKTSVTPLRENSLMKLGESALSWESEVFDNTLEPLAEAEWSSATALLSEENLESE 502

  Fly   451 VSELKNK-----LDQREQAQFGNEN----TNGDNEMRDFSLLVNRVH--VELQRTQE-----ELE 499
            ::.|..:     ||. ||.:..||:    ....||:.:|..|..|..  .|||...|     .|.
  Rat   503 LTSLNTQYNNLVLDY-EQLRRENEDLKLKLKEKNELEEFEFLEQREEKDQELQLMHEVSNLKNLI 566

  Fly   500 SQGHESRQRLSSR--SHTEGGESGGDEVHEM---LHSHSEEYTNKQMNFAGELRNINRQLDLKQE 559
            ....|..|.|.:.  |..|..:...|::.|:   :.:...|.|...::::.|...     ||||
  Rat   567 KHAEEYNQDLENELSSKVELLKEKEDQIKELQRYIDAQKSETTKTDLSYSSEATE-----DLKQ- 625

  Fly   560 LHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERR--DLMDQLRNIKS------KDISAK--LA 614
                .||..|.||:...|.|......:.::||.:.|  :|.|..:.:::      :.:.||  :.
  Rat   626 ----AMRTLSDLDTVALDAKRESAFLRSENLELKERINELSDSCKQMENGIQMYQRQLEAKKQVQ 686

  Fly   615 EERRKRLQLLEQEISDLR--------------RKLITQANLLKIRDKEREKIQNLSTEIRTMKES 665
            .:..|.|||..||||.|.              .|.||  :|.|..:||.|:.:.|..|:..:.|
  Rat   687 ADLEKELQLAFQEISKLSALVDGKGLLSNLELEKRIT--DLQKELNKEVEEKETLQKEVHLLSE- 748

  Fly   666 KVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAAN 730
                ::::..|.|..|:....:.:||..:.::..|:.||:..:                     :
  Rat   749 ----LKSLPSEVETLRRELHEKSEELCVITTEREKLFSEMAHK---------------------D 788

  Fly   731 KRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSL-IDAEHSLEQLMED 794
            .|::..||...:.       ||:..::..|..::       |.|.:.:.|| ::.:|..|:::|:
  Rat   789 SRIQGLLEEIGNT-------KDDLAASQLSQRSS-------DEECQALKSLHVELKHRQEEVLEE 839

  Fly   795 RAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEG 859
            ...:........||.....||..|....:..|.|:||.|::.:...:::  ...|..:::...|.
  Rat   840 SERVKQELSQKTQELAQKTAEGQEMLNQMEELREKLERRDSSLQSAEKE--KNLLTEKLQQTLEE 902

  Fly   860 VQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQE-DAASKRLRLLQS-- 921
            |::|.:.:...|||.::|..:|              |:||:.:.|..... |...:.|..|:|
  Rat   903 VRALTQEKNDLKQLQESLQTER--------------DQLRSDIQDTVNMNIDTQEQLLNALESLK 953

  Fly   922 QHEEQM-LAQQRAYEE-------------------------KVSVLIRTANQRWAEARSPAEDQQ 960
            ||:|.: :.:.:|.||                         :.::|..:|:..........|.::
  Rat   954 QHQETINMLKMKATEEMSDHLPIKGREGSSDEVEQKLDGIDEENLLAESAHTVVGSGEDHGETEE 1018

  Fly   961 RNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQI-VDGNETV-VLSD------ 1017
            :.:| :.||.....|||.|:.:.|: |.:.|      .||.::.:: |:..|.: :|.|
  Rat  1019 QRKI-DSLLQENSRLQQTLESIIAE-KEQLK------MDLKENIEMSVENQEELRILRDELKRQQ 1075

  Fly  1018 --VSDDPDWVPSTS-------------------KSKRIQSDSRNVISPPE---KQDANVTSLGNS 1058
              .:.:.|.|...|                   |::::|...:.::|..|   :..|.||.|.|.
  Rat  1076 EIAAQEKDHVTEKSEELSRAHERLAEIEEKLKEKNQKLQETQQQLVSIQEAMSEMQAKVTDLENL 1140

  Fly  1059 SIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPL----------- 1112
            ..:..|...|.|            :..|:|.......:...|.....:..||.|
  Rat  1141 QNEFRNQALALE------------RVETERLELAQKLHENYEKMESITKERNDLKELQESFEIEK 1193

  Fly  1113 --------------------------NLKDHASQCGDGDGQKDETE-DADKSDDDGDDEPQTSKE 1150
                                      |||::.....:..|...|.| .|..:.|.|...|.:..|
  Rat  1194 KQLKEYAREMESAGLQTKEQLNIAHANLKEYQEIIKELRGSISEKEAQASSTQDTGKTNPASQGE 1258

  Fly  1151 NAV---KFVTPEAPGKVVASPKQTLQEPKAAATPLMNSNVVEDINGPKLA 1197
            ..|   :.:.|:|.....::.|.:..||....:...:|...|.|....||
  Rat  1259 TPVPREQELLPDAEEARASAEKGSELEPVEEHSRTAHSLTTEGIEMEILA 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	133/335 (40%)
		Smc	<453..>985	CDD:440809	129/606 (21%)
		Metallothio	<1071..1115	CDD:395080	7/80 (9%)
Cenpe	XP_063138291.1	None