Protein Alignment Klp3A and Kif14

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001414162.1
• Gene: Kif14 / 360849
• RGDID: 1310650
• Length: 1672
• Species: Rattus norvegicus
• Alignment Length: 1325
• Identity: 350/1325 - (26%)
• Similarity: 547/1325 - (41%)
• Gaps: 306/1325 - (23%)

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNE-SYTYNYVFDI-----DD------ 59
            |.|.||:||||..:.|........|.|:.:   ::||...: ...|::::|:     |:
  Rat   392 SQVTVAVRVRPFSKREKTEKASQVVFRNGE---EITVEHPDMKQIYSFIYDVAFWSFDECHPGYA 453

  Fly    60 SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDIFTA 123
            :|..::||.....:.:...|||..:.|||||||||:|| ||      |::..|:|||...|:|..
  Rat   454 NQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMG------LNEEPGIIPRFCEDLFAQ 512

  Fly   124 IAEMQ-SEFRFAVTCSFVELYQEQFYDLFSSKTRD---KATVDIRE--VKNRIIMPGLTELVVTS 182
            ||:.| ||..:.:..||.|:|.|:.:||...|..:   |..:.:||  |....: .||:..||:|
  Rat   513 IAKKQASEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRVREHPVSGPYV-EGLSMNVVSS 576

  Fly   183 AQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK---LDGKQ--SVTTSRFNLVDLAG 242
            ...:...|..|:..||.|||.||:.|||||::|||.:..||   ::|::  ...|||.||:||||
  Rat   577 YSDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAG 641

  Fly   243 SERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAG---YIPYRQSKLTRLLQDSLGGNS 304
            |||||...:||:|.||||:|||.||.||.||:|| |.||.|   :||||:|.||.||::||||||
  Rat   642 SERCSTAHSSGERLKEGVSINKSLLTLGKVISAL-SEQANGKRVFIPYRESTLTWLLKESLGGNS 705

  Fly   305 ITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGK 369
            .|.|||.:|||..|:.|||||||||.:|..|.|...||.|.:|..:..||..|:||:....|...
  Rat   706 KTAMIATISPAASNIEETLSTLRYATQARLIVNVAKVNEDMNAKLIRELKAEIEKLKAAQKSSRN 770

  Fly   370 MSSSLISAVGAAGLGAIPCEESLAG-------SMANAAEIQRL-KEQVRTLQDRNRKLQQELHQS 426
            :.......          |.:.::.       ...:.|||||: ||:..  |...||||:
  Rat   771 IDPERYRL----------CRQEISSLRMKLHQQERDMAEIQRVWKEKFE--QAEKRKLQE----- 818

  Fly   427 LLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQF------------GNENTNGDNEMRD 479
                |::..:|.:..|    :.:|:..|.|..:..:.::.            |....|..::::.
  Rat   819 ----TKELQKAGVTFQ----MDNHLPNLVNLNEDPQLSEMLLYMVKEGITTVGKHTPNSSHDIQL 875

  Fly   480 FSLLVNRVHVELQRTQEEL------ESQGHESRQRLSSRSHTEGGES---GGDEVHEMLHSHSEE 535
            ..:|:...|..::.....:      |::.:.:...:|..:....|:.   |||  |....:|..|
  Rat   876 SGVLIADDHCTIRSYGGTVSIVPAGEAKTYVNGMHISEPTVLHHGDRVVLGGD--HYFRFNHPVE 938

  Fly   536 YTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLR------------------- 581
            ....:......|.:...: |.:...:|.:....|||:::.:|.:|:
  Rat   939 VQKGKKTSRNNLTSEGPK-DFEFAKNELLAAQRSRLEAEIKDAQLKAKEEMMQGIQIAKEMAQQE 1002

  Fly   582 LCNQ------KIDDLEAERRD--LMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKL--- 635
            |.:|      ||..||||.|:  ...:|..|.::..|.|: ||..|..|.||||:...:|:|
  Rat  1003 LSSQRAAYENKIRALEAELREESQRKRLEEINNQKASHKI-EELEKAKQHLEQEVYVNKRRLEME 1066

  Fly   636 ------------ITQANLLKIRDKEREKIQNLSTEIRTMKE---------------SKVKL---I 670
                        |..|.:|:..::|::||   :.|::.::|               |.:||   |
  Rat  1067 TLATKQALEDHRIRHARILEALEREKQKI---AEEVQILQENRGNRNKTFTIQPNWSSMKLSTMI 1128

  Fly   671 RAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKD 735
            :.....|:||::..:....:.:   .|.|...|..||...|.......|: |.|..|||.|.|
  Rat  1129 QEANAISDKFKKHYVFGRHDAS---DKGRSDPSVRVRNLQLGISTFWNLE-KFESKLAAMKDL-- 1187

  Fly   736 ALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVIN- 799
                          |:.|.|: .|........|.|........:|.:....| ..||::|.|..
  Rat  1188 --------------YESNSGT-RGEDVFCDPEDEWEPDITSTPVSSLSRRRS-RSLMKNRRVSGC 1236

  Fly   800 -NHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSL 863
             :..|.:|....|..:...|:...:.|...|         .....:|...:.|.|..|.   ||.
  Rat  1237 LHDIHPIQSMHPSHTSGLMEKPSTIYSNSSE---------SFLPGICKELIGSSIDFLG---QSF 1289

  Fly   864 GESRTVSKQLLKTLVQQRR--LQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQ 926
            .|.:|::..|:..|::...  :..|..:|::           |.:.|::..|.|.       .:.
  Rat  1290 DEEKTIADSLINNLLKLYNGVIAISKAHEEQ-----------DEESQDNVFSDRA-------AQA 1336

  Fly   927 MLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDK--------LR 983
            :..|.....|::.||.:    .|.:...|.....|   ||      |.|:|::.|        |:
  Rat  1337 LTIQVACAFEQLVVLFK----HWLDDFPPCSGSAR---LE------EELRQDIKKLGGYLQLFLQ 1388

  Fly   984 AKNKSKSKAVKSEPQDLDDSFQ----------IVDGNETVVLSD---VSDDPDWVPS----TSKS 1031
            ......|..||.....:.:..|          ::.|::..||.|   ||...:.:.:    |:..
  Rat  1389 GCCSDISSMVKEAQNKVTEIIQQAVGHVAQLAVLKGSKLCVLEDSNKVSSAQELMAALQDGTASG 1453

  Fly  1032 KRIQSDS--------RNVIS----PPE---KQDANVTSLGNSSIQSLNSTSA----------TED 1071
            .|...||        |..:|    |.|   :..||...|    :.||.:..|          .|:
  Rat  1454 MRSLLDSGLETAQELRQDVSRQSAPEEVTRQMKANAVEL----VGSLENIFAEWRTKSFRTQVEE 1514

  Fly  1072 GKRCKGCKCRTKCT--TKRCGCL--------SGNNACSETCVCKSNCRNPL------------NL 1114
            |.|.:|.|.....:  .|...||        |....|.....|..:|...:            .|
  Rat  1515 GSRQQGSKVLNLASEFLKLKSCLQQTIEMVVSALRGCPSDLRCLRSCTETICGLAHKLHGGFSAL 1579

  Fly  1115 KDHASQCGDGDGQK--DETEDADKS 1137
            .|.|..||:...:.  :|.|...||
  Rat  1580 SDSAGSCGNEQPRAVWEELESLAKS 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	153/355 (43%)
		Smc	<453..>985	CDD:440809	123/624 (20%)
		Metallothio	<1071..1115	CDD:395080	11/65 (17%)
Kif14	NP_001414162.1	None