Protein Alignment Klp3A and klp-20

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_497178.1
• Gene: klp-20 / 3565057
• WormBaseID: WBGene00002230
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 709
• Identity: 214/709 - (30%)
• Similarity: 321/709 - (45%)
• Gaps: 166/709 - (23%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNE---------------SYTYNYVFDID 58
            |.|.:|.||:..:|..:|.:||          ||.|..|               ::.::.||..:
 Worm     7 VKVVVRCRPISTTEKLQGHKIA----------VTCNDEEKAVNIKSLSQEDPPRTFYFDAVFSPN 61

  Fly    59 DSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTA 123
            ..|..::....:..|:.:|.|||.||.||||||:|||:||......|  :..|:||.:...||..
 Worm    62 TDQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPV--EMRGIIPNSFAHIFDH 124

  Fly   124 IAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR----IIMPGLTELVVTSAQ 184
            ||:.|.:..|.|..|::|:|.|:..||.|.......     |:|.|    :.:..|:...|.:|.
 Worm   125 IAKCQHDTTFLVRVSYLEIYNEEIRDLLSKDHNGNL-----EIKERPDVGVYVRNLSNPTVENAS 184

  Fly   185 QVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKT 249
            ::...:..||..|.|.|||||..||||||:||:|:.:.:   ...||..:..|||||||||.|||
 Worm   185 KMQALMEFGSKNRKVGATAMNLESSRSHAMFTVTIESCR---NGLVTQGKLQLVDLAGSERQSKT 246

  Fly   250 LASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSP 314
            .|.|:|.||...||..|..|||||::|..|::. :||||.|||||||||||||||.|:|||.|.|
 Worm   247 GAQGERLKEAAKINLSLSTLGNVISSLVDGKST-HIPYRNSKLTRLLQDSLGGNSKTVMIANVGP 310

  Fly   315 ADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVG 379
            |.||..|||||||||:||..|:|...:|.||..|::...:..|:.||..|
 Worm   311 ATYNYDETLSTLRYANRAKNIQNVAKINEDPKDAQLRKFQLEIEALRKIL--------------- 360

  Fly   380 AAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQ-DRNRKL----------QQELHQSLLDLTEK 433
                     :|...|...|..|....|.|.|.:: ::.||:          .:|.|:.:.::.|.
 Worm   361 ---------DEENPGDDENQEEAWEAKMQEREVEMEKKRKILEERVNSAVNDEETHRLVKEMMEN 416

  Fly   434 EMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEEL 498
            |.....|...|:||||.:.:::.||      ..|.||            |:.:|
 Worm   417 EAELKKARSEHEKLRSKLEKIEKKL------IVGGEN------------LLEKV----------- 452

  Fly   499 ESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHER 563
                 |.:.:|...::.|..:|...|.|  |.:..||.|                 .:|.|:.||
 Worm   453 -----EEQAKLLEVNNKELEQSKFQEAH--LRTQLEERT-----------------AVKVEIEER 493

  Fly   564 IMRNFSRLDSDD--EDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQ 626
                :|.|..:.  :..|::..:.::.|..||.:|                |.|:.:::::.:..
 Worm   494 ----YSSLQEEAFVKSKKIKKVSNELKDARAELKD----------------LEEDHQRQVEAMLD 538

  Fly   627 EISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKM 685
            :|..||::|:.                |::.....:....|:||......||:...|::
 Worm   539 DIRQLRKELLL----------------NIAIIDEYIPVEHVELIEKYVSWSEEHGDWQL 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	144/345 (42%)
		Smc	<453..>985	CDD:440809	41/235 (17%)
		Metallothio	<1071..1115	CDD:395080
klp-20	NP_497178.1	Motor_domain	5..331	CDD:473979	144/344 (42%)
		Smc	<325..>556	CDD:440809	67/343 (20%)