Protein Alignment Klp3A and Kif15

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_038937602.1
• Gene: Kif15 / 353302
• RGDID: 727790
• Length: 1396
• Species: Rattus norvegicus
• Alignment Length: 1299
• Identity: 336/1299 - (25%)
• Similarity: 541/1299 - (41%)
• Gaps: 356/1299 - (27%)

  Fly     2 SSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVN-------------RNESYTYNY 53
            |:|| ..:.|.:|:||..:.          .|||||...:.::             ..:::.::|
  Rat    21 SNED-DAIKVFVRIRPAEEG----------ARSADGEQSLCLSVLSQTALRLHSNPDPKTFVFDY 74

  Fly    54 VFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHV-GVIPRA 116
            |..:|.:|:.:|.|..::.|:..::|||.||.||||||||||:| ||.:.:.....:: |||||:
  Rat    75 VAGMDTTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGVIPRS 139

  Fly   117 VHDIFTAIAEMQSEF----RFAVTCSFVELYQEQFYDLFSSKTRDKATVD--IRE-VKNRIIMPG 174
            ...:|:.|...:.:.    .|...|||:|:|.||.|||.     |.|:|.  :|| :|..:.:.|
  Rat   140 FEYLFSLIDREKEKAGAGKSFLCKCSFIEVYNEQIYDLL-----DSASVGLYLREHIKKGVFVVG 199

  Fly   175 LTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQ-SVTTSRFNLV 238
            ..|.||.||.:....|.||...|.||:|:||..||||||:||:|:.:.:...:. ::.||..|||
  Rat   200 AVEQVVASAAEAYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEKSSEAVNIRTSLLNLV 264

  Fly   239 DLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINAL---GSGQAAGYIPYRQSKLTRLLQDSL 300
            |||||||...|.|.|.|.||..|||:.|..||.||.||   |:|:.. ::.||.||||.||:|||
  Rat   265 DLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQR-HVCYRDSKLTFLLRDSL 328

  Fly   301 GGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVEL- 364
            |||:.|.:||.|.|......||||||.:|.||..||||.|||.|.. ..|:.|:..:::||.:|
  Rat   329 GGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNVSQLQAEVKRLREQLS 392

  Fly   365 -LSGGKMS--SSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQS 426
             .:.|:::  |||......|.......|..|....:. .|.:.|.|::..|:|...|.::.:..:
  Rat   393 QFTSGQLTPGSSLARDKEKANYMEYFLEAMLFFKKSE-QEKKSLVEKITQLEDLTLKKEKFIQSN 456

  Fly   427 ------------LLDLTEKEMRAHIAEQAHDKLRSHVSELKNKL-DQREQ-------AQFGNENT 471
                        .|:..:||.|.....:..|:|   :|||:::: ..|||       |::..||.
  Rat   457 KMIVKFREDQIMRLERLQKEARGSFLPEEQDRL---LSELRDEIRTLREQVEHHPRLAKYAMENH 518

  Fly   472 NGDNEMRDFSLL--VNRVHVELQRTQEELESQG-HESRQRLSSRSHTEGGESGGD---------- 523
            :...|.|...||  |.|.|        ||::|. ....|..|..|.||..:.|..
  Rat   519 SLREENRKLKLLAPVKRAH--------ELDAQAIARLEQAFSEVSSTETNDKGLQGLPPKAIKEP 575

  Fly   524 --------------EVHEMLHSHSEEY-------TNKQMNFAGELRNINR-QLDL---------- 556
                          ::...|::..:||       ..||:....||:::.: .|:|
  Rat   576 SFFTSTEKLKVQLLQIQTELNNSKQEYEEFKELTRKKQLELESELQSLQKANLNLENLLEATKVC 640

  Fly   557 -KQELHE------------------------------------RIMRNFSRLDSD--DEDVKLRL 582
             :||:.:                                    ..:|:.|..|:|  :|.|...:
  Rat   641 KRQEVSQLNKIHAETLKIITTPTKAYQLCSRLVPKSSPEVGSFGFLRSQSAPDNDILNEPVPPEM 705

  Fly   583 CNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDK 647
            ..|.::.:..|.|.:.:||     ..:..||.||..|.|:|              |.|:
  Rat   706 SEQALEAISEELRTVQEQL-----SVLQVKLDEEEHKNLKL--------------QQNV------ 745

  Fly   648 EREKIQNLSTEIRTMKE--SKV-----KLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEI 705
              :::::.||:   |:|  |.|     ||..:.|.:      |...::..||||...::::|...
  Rat   746 --DRLEHHSTQ---MQEHTSPVCSLFPKLFSSERSD------WSKQQQDYLTQLSDLEKQLQDAQ 799

  Fly   706 VRQQTLHSKQRQVLKRKCE------EALAANKRL----------KDALERQASAQAQRHKYKDNG 754
            .:...|          |||      ...:|:|.|          |::.|::.|..::||
  Rat   800 TKNDFL----------KCEVHDLRIVLNSADKELSLVKLEYSTFKESQEKELSQLSERH------ 848

  Fly   755 GSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQ------------- 806
                                :::.|.|.:|....|:|:|.:|.:.:.|..||
  Rat   849 --------------------VQVQLQLDNARLENEKLLESQACLQDSYDNLQEVMKFEVDQLSKN 893

  Fly   807 -----QEK---TSD--------PAEAAEQARILASLEEELEMRNAQI--------SDLQQKV--C 845
                 ||.   .||        .||.....::....||:.|..:.:|        .:.|:::  |
  Rat   894 LQNCKQENETLKSDLHNLVELFEAEKERNNKLSLQFEEDKENSSKEILKALETVRQEKQEEMARC 958

  Fly   846 PTDLDSRIRSLAEG-------VQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLL 903
            ...: ::::.|.|.       |..|.:||...|:|:..|:.|.:...:|..|:...:|.|:.:|.
  Rat   959 EKQM-AKVQELEESLLAAENVVSCLEKSRESDKELVTNLMNQIQELRTSAGEKSEAIDTLKQELQ 1022

  Fly   904 DAQQQEDAA------SK-----------------RLRLLQSQHEEQMLAQQRAY-EEKVSVLIRT 944
            |...:..||      ||                 |||:|....|..||.:..|: .|::::|...
  Rat  1023 DISCKYTAAVADKEESKELIRRQEVDILELKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEA 1087

  Fly   945 ANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDG 1009
            :.:.....:|..|:          |:.:|||.|||.....:.|.:.:..|||........:.|.|
  Rat  1088 SKKHSGLLQSAQEE----------LTKKEALIQELQHKLNQEKEEVEQKKSEYNLKMKQLEHVMG 1142

  Fly  1010 NETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNS--TSATED 1071
            :.          |::..|.......|:....::...|::..:    |.:|..||..  |...||
  Rat  1143 SA----------PEYPQSPKTPPHFQTHLAKLLETQEQEIED----GRASKMSLQHLVTKLNED 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	140/354 (40%)
		Smc	<453..>985	CDD:440809	143/716 (20%)
		Metallothio	<1071..1115	CDD:395080	1/1 (100%)
Kif15	XP_038937602.1	KISc_KLP2_like	25..373	CDD:276824	147/363 (40%)
		COG5022	<425..961	CDD:227355	117/619 (19%)
		SMC_prok_B	<704..1386	CDD:274008	119/586 (20%)