Protein Alignment Klp3A and Klp31E

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Alignment Length: 1192
• Identity: 324/1192 - (27%)
• Similarity: 540/1192 - (45%)
• Gaps: 260/1192 - (21%)

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQA 71
            |.|.||:|:||....||...|||....:. |.||:.:..::::|::||||.:.:|.|::..||:.
  Fly    12 SSVRVAVRIRPQNSRELIDMCRICTTVTL-GEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEK 75

  Fly    72 KVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH---------VGVIPRAVHDIFTAIAEM 127
            .|...|:|||.|:||||||||||||||||.|     ||         :|:|||||..||:.|.::
  Fly    76 LVDSTLHGYNATVLAYGQTGSGKTYTMGTGF-----DHESESSDSVQLGIIPRAVRHIFSGIEQL 135

  Fly   128 Q----SEF-------RFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVT 181
            :    ||.       :|::...::|||.|..:||.....::.......:...:|.:.|.:...:.
  Fly   136 EGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIY 200

  Fly   182 SAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKL--------DGKQSVTTSRFNLV 238
            .......:|.:|:..|..|:|.||:.||||||:||:.:...:|        |......||:|:.|
  Fly   201 QPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKFHFV 265

  Fly   239 DLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYRQSKLTRLLQDSLGG 302
            |||||||..:|.|:|:|.:||::||.|||||||.|:||| ..:.|.::|||.|||||||||||||
  Fly   266 DLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGG 330

  Fly   303 NSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSG 367
            ||.|||||||||:|.:..|||:||:||:||..||||..:|.|..:..::.|:..|..|::|||.
  Fly   331 NSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLE- 394

  Fly   368 GKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTE 432
            .|....::...|...:.....|..|.     .:||:||::::::||           .::..||:
  Fly   395 YKQGKLIVDCEGNTTISDTFNENKLL-----LSEIKRLQQRLKSLQ-----------STIATLTQ 443

  Fly   433 KEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEE 497
            :.                 ::||..||.       |:.|:.||...:.:.:|.:..:|::..|.:
  Fly   444 RN-----------------ADLKTNLDL-------NKWTSDDNSDVEIAKVVGQYMLEIEELQTK 484

  Fly   498 L-ESQGHESRQRLSSRSHTEGGESGGD------------EVHEMLHSHS------EEYTNKQMNF 543
            | ||:.|..:..:.:.:.....:...|            ...|:|.|.|      :..::::...
  Fly   485 LIESEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEV 549

  Fly   544 AG----------ELRNINRQLDLKQELHERIMRNFSRLDS----DDEDVKLRLCNQKIDDLEAER 594
            |.          :|..|:..::::.:|.|::....||.:.    .:|.:.:..|  ||::.:.||
  Fly   550 ASSDSEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYC--KIENTQKER 612

  Fly   595 RDLMDQLR---NIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREK----- 651
            .|::..:.   :..|||...|:..:...::..::.||    ||| ..|....||.|::.|
  Fly   613 DDVLANMTTSVSTPSKDSLKKVKTDYESKISHMQTEI----RKL-QNAQREHIRSKQQLKSHEVR 672

  Fly   652 IQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQR 716
            |..|..|:..:|.:||||::.|..:|.:.:|.:..:.||:.||..:.|:.::.::..:...|.:.
  Fly   673 IGTLRNELNELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKE 737

  Fly   717 QVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSL 781
            |:||||.||.:|..|       .|.....||        :.|..::..|..|.:..|
  Fly   738 QILKRKTEEVIALRK-------SQRGKSGQR--------APAHLTSKIATLDGFSTR-------- 779

  Fly   782 IDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELE--------------- 831
             .|.|..|.|      ..|..|            ||...:::..||:|||
  Fly   780 -SARHRWENL------YRNILH------------AARNRQLITQLEKELERLILEREDLSRELNI 825

  Fly   832 MRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLD 896
            |.|.|.:|.|     ||..:.:.:|...:..:.|:                            ::
  Fly   826 MENGQTADRQ-----TDEFNEVDNLKTNISYIQEN----------------------------IE 857

  Fly   897 ELRAQLLDAQQQEDAASKRLRLLQSQHEE-QMLAQQRAYEEKVS--VLIRTANQRWAEARSPAED 958
            .::..:::.:..:|.....:..:||..:| ..:|:.:...:|.|  .::.:.|...||:..
  Fly   858 HVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHL---- 918

  Fly   959 QQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSF---------QIVDGNETVV 1014
            |::..:|:|:.......||.|....::|.:...|      |:.||.         .:..|::..:
  Fly   919 QEKESLLKEVKQESGIQQQILQHFLSQNSNVHIA------DIFDSLNLKGSNIASSVNPGSQKSL 977

  Fly  1015 LSDVSDDPDWVPSTSKSKRI-QSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGC 1078
            :|:.:.|   :|...|:... |.:.|...|      .:.:.||||....             |..
  Fly   978 ISNATYD---IPQDDKNSEFHQVEMRRTTS------RSPSPLGNSDPFD-------------KSP 1020

  Fly  1079 KCRTKCTTKRCGCLSGNNACSE 1100
            |.|.: |.||...|.|:...||
  Fly  1021 KVRRR-TAKRQDLLFGDTELSE 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	154/357 (43%)
		Smc	<453..>985	CDD:440809	119/590 (20%)
		Metallothio	<1071..1115	CDD:395080	10/30 (33%)
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	154/357 (43%)
		Mplasa_alph_rch	<372..>748	CDD:275316	91/423 (22%)
		SMC_prok_B	622..>899	CDD:274008	74/356 (21%)
		Rcc_KIF21	798..870	CDD:410202	14/104 (13%)