Protein Alignment Klp3A and Kif16b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_038960967.1
• Gene: Kif16b / 311478
• RGDID: 1310146
• Length: 1876
• Species: Rattus norvegicus
• Alignment Length: 1514
• Identity: 361/1514 - (23%)
• Similarity: 579/1514 - (38%)
• Gaps: 458/1514 - (30%)

  Fly    17 PLVQSELDRGCR--IAVERSADGAPQVTV----------NRNESYTYNYVFDIDD-------SQK 62
            |:.:.|.|...:  |.:|:|......:.:          .|.:::||::.|...|       ||:
  Rat    15 PMSKQEKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQE 79

  Fly    63 DLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDIFTAIAE 126
            .:|:|.....||....|||..:.|||||||||:|| ||.:.:.      |:|||....:|:.|.|
  Rat    80 TVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDS------GLIPRICEALFSRINE 138

  Fly   127 MQ--SEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTD 188
            ..  .|..|....|::|:|.|:..||...|:.....:.:|| .|....:..|::.:|.:...|.:
  Rat   139 TTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEE 203

  Fly   189 HLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSV-TTSRFNLVDLAGSERCSKTLAS 252
            .:..|:..|..|||.||:.|||||||||:.....|.|.:... |.|:.:|||||||||...|.|:
  Rat   204 LMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDAEMPCETVSKIHLVDLAGSERADATGAT 268

  Fly   253 GDRFKEGVNINKGLLALGNVINALG--SGQAAG--------YIPYRQSKLTRLLQDSLGGNSITL 307
            |.|.|||.||||.|:.|||||:||.  |..||.        ::|||.|.||.||:|||||||.|:
  Rat   269 GVRLKEGGNINKSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDSVLTWLLKDSLGGNSKTI 333

  Fly   308 MIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSS 372
            |||.:||||.|..|||||||||:||..|.|||.:|.|.:...:..|:..|.:|:. ||:.|...:
  Rat   334 MIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKT-LLAQGNQIA 397

  Fly   373 SLISAVGAAGLGAIPCEESLAGSMANAAEIQR------------LKEQVRTL------------- 412
            .|.|..      |:..||.|..:.|...|:.:            ||||...|
  Rat   398 LLDSPT------ALSMEEKLHQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSEL 456

  Fly   413 -----------------------------QDRNRKLQQELH------------------------ 424
                                         :|.:.:....||
  Rat   457 PHLIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENAGGTVTLIPLS 521

  Fly   425 --------QSLLDLTEKEMRAHIAEQAHDKLR-SHVSELKNKLDQREQ---AQFGNENTNGDNEM 477
                    ..::|.|:....|.|.....:..| :|..|.....::|:.   :.|....|:.....
  Rat   522 GSQCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSC 586

  Fly   478 RDFS--LLVNR----------VHVELQRTQ-EELESQGHESRQRLSSRSHTEGGESGGDEVHEML 529
            .:.|  :|.|.          :.:|.:|.| ||||..  ||:::|
  Rat   587 ENLSAVMLYNPGLFPMKGPICLRLEFERQQREELEKL--ESKRKL-------------------- 629

  Fly   530 HSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRL--CNQKIDDLEA 592
               .||...||.:...||..:.::::.:::..|.:.|   ::...:|.:|.|.  ...|:.||.|
  Rat   630 ---IEEMEEKQKSDKAELERMQQEVETRRKETEIVQR---QIRKQEESLKRRSFHIENKLKDLLA 688

  Fly   593 ER-----------RDLMDQLRNIKSKDISAKLAEERRKRLQLLE-----------QEISDLRRKL 635
            |:           :.|..|.|  :.:|...::.||.| |||.|.           |::..|.|:.
  Rat   689 EKERFEEERLREQQGLEQQKR--QEEDSFFRIREELR-RLQELNSHEQAEKGQPLQDLDWLHREQ 750

  Fly   636 ITQANLL-----KIRDKERE---KIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKE-- 690
            ..|:..|     ::.::|:|   ::.:|..::|..:::...|   ..||:::.::.:  ||.|
  Rat   751 DAQSAKLQLEKRRLEEQEKEQVLRVAHLEEQLRKRQDTAPLL---CPGEAQQAQEER--RELEGI 810

  Fly   691 ---LTQLK----SKDRKMQSEIVRQQT--LHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQ 746
               |.|.|    ..|...:.|:.|.|.  |..|:||::|....|.....::.:.:.|.|...:|.
  Rat   811 RGALLQAKEIRAGGDHTFRGELERAQQYFLEFKRRQLVKLATLEKDLVQQKDRLSKEVQEEKEAL 875

  Fly   747 RHKYKDNG--GSAAGSSNANAKTDSWVDRELEIILS----LIDAEHSLEQLMEDRAVINNHYHLL 805
            .|...:.|  .|...:.|.|....   .::|:.|.:    |...||.|:.|:::        ||
  Rat   876 EHVKCEAGEEPSLLATDNCNILCG---PQDLDKIKTAESRLQSKEHQLQDLLQN--------HL- 928

  Fly   806 QQEKTSDPAEAAEQARILASL--------------EEELEMRNAQISDLQQKVCPTDLDSRIRSL 856
                   ||...|:.|:|..|              |:|:|.:..||:..|...      |:::.|
  Rat   929 -------PALLEEKQRVLEILDCGVLGLDNILYHVEKEMEEKEEQITQYQANA------SQLQQL 980

  Fly   857 AEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRL-LQ 920
            ...||.   :..|::|..|...:::.:..|...:||..|::..|:|   :|:..|..:|..| |:
  Rat   981 QATVQF---TANVARQEEKVRRKEKEILESQEKQQREALEQAVAKL---EQRHSALKRRSTLDLE 1039

  Fly   921 SQHEEQMLAQQRAYE-------------------EKVSVLIRTANQRWAE--------------- 951
            .|.:.|.|....:.|                   .::...|....|:..|
  Rat  1040 IQEQRQKLGSLHSSEWPGLQASLEANGERLQMDPARIEHEIHELKQKICEVDGVQRPHHGTLEGK 1104

  Fly   952 -ARSPAEDQQRNQILEELLSSR------EALQQELDKLR----------AKNKS----------- 988
             |.|.......|..|..|:.:|      |.:|:.|..|.          |:.||
  Rat  1105 AALSSLPPSAENSHLAPLMDARISAYIEEEVQRRLHDLHRVISDASHAPAELKSNEELHNGATQR 1169

  Fly   989 KSKAVKSE-----------PQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVI 1042
            |.|..|.:           |:|..||..:: |.|    |:|.....|....|::..:.:|....
  Rat  1170 KLKYEKGQPWSARCGIPLLPKDAVDSPSVL-GEE----SEVYPSSQWSHPVSQNTSLSTDFSLA- 1228

  Fly  1043 SPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSN 1107
                .|:..|.|.|::.::|::...                |..:..|.|            :.|
  Rat  1229 ----SQERIVLSSGHAVLKSIDDKF----------------CYPESSGHL------------EPN 1261

  Fly  1108 CRNPLNLKDHASQCGDGDGQKDETEDADKSD----------------------------DDGDDE 1144
            |.:.|.:.. .::....|.|..:.|..:.|.                            |.|..:
  Rat  1262 CVHLLEISS-LNERNSRDAQSSQIESENSSGLMTHEEKQSWGTESSWTLSQHMSQQAPVDRGSQQ 1325

  Fly  1145 PQTSKENAVKFV-----------TPEAPGKVVA--------SPKQTLQEPKAAATPLMN------ 1184
            ...|:|  :.||           |..:|..|.|        |.|.:..:..:...||:|
  Rat  1326 AMQSRE--LLFVLSESVSQREHPTGSSPQSVSASTLSCEQQSEKDSAVKNTSVLAPLVNIRTEAK 1388

  Fly  1185 ----------SNVVEDING 1193
                      |::.:|.:|
  Rat  1389 KRLGYVYHKFSDLYKDTSG 1407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	141/352 (40%)
		Smc	<453..>985	CDD:440809	136/662 (21%)
		Metallothio	<1071..1115	CDD:395080	6/43 (14%)
Kif16b	XP_038960967.1	KISc_KIF1A_KIF1B	15..368	CDD:276816	145/358 (41%)
		Kinesin_assoc	367..479	CDD:465047	21/118 (18%)
		FHA	449..565	CDD:469597	10/115 (9%)
		Smc	<609..>1087	CDD:440809	118/544 (22%)