DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Kif21a

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	XP_038934825.1	Gene:	Kif21a / 300158	RGDID:	1305126	Length:	1681	Species:	Rattus norvegicus

Alignment Length:	1345	Identity:	352/1345 - (26%)
Similarity:	597/1345 - (44%)	Gaps:	266/1345 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKVKKLL 77
            ||:||.:..|...||.|... ...|.|||.:.:::::|::||||||..|:.::..|::..::...
  Rat    18 LRIRPQLAKEKIEGCHICTS-VTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYTQCIEKLIEGCF 81

  Fly    78 NGYNVTILAYGQTGSGKTYTMGTAFN-GVLDDHVGVIPRAVHDIFTAIAEMQSEF--------RF 133
            .|||.|:.||||||:||||||||.|: .::::..|:|.|||..:|.:|.|.::..        .|
  Rat    82 EGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVKHLFKSIEEKKTSAIKNGVPPPEF 146

  Fly   134 AVTCSFVELYQEQFYDLFSSKTRD------KATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLI 191
            .|...|:|||.|:..|||.: |||      |:.:.|.| ....|...|:|...|.:..::...|.
  Rat   147 KVNAQFLELYNEEVLDLFDT-TRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTVNTEPEMMQCLK 210

  Fly   192 RGSAGRAVAATAMNETSSRSHAIFTLTLVATKL----------DGKQ----------SVTTSRFN 236
            .|:..|..|:|.||..|||||||||:.:..|::          |.|.          ...|::|:
  Rat   211 LGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENVTDNKMVSESPQMNEFETLTAKFH 275

  Fly   237 LVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYRQSKLTRLLQDSL 300
            .||||||||..:|.|:|:|.|||::||.|||||||||:||| ..:.|.::|||.|||||||||||
  Rat   276 FVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSL 340

  Fly   301 GGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELL 365
            ||||.|:|||||||:|.:..|||:||:||:||..||||.:||.|..:.::|.|:..|.:|::||:
  Rat   341 GGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELM 405

  Fly   366 SGGKMSSSLISAVGAAGLGAIPCEESLAGSMAN--AAEIQRLKEQVRTLQDR------------- 415
            . .|....:|...|...:..:..|.::..:..|  ...|:.::|.|..|:.|
  Rat   406 E-YKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRARITQLVSEQANQVL 469

  Fly   416 ------NRKLQQELHQSLLDLTEKEMRAHI--AEQAHDKLRSHVS-------------------- 452
                  |.::...:|..:.::  :::||.:  :|..::.||..::
  Rat   470 ARAGEGNEEISNMIHSYIKEI--EDLRAKLLESEAVNENLRKSLTRATARSPFFSASSAFSSTIL 532

  Fly   453 ------------------ELKNK-------------LDQREQAQFGNE-NTNGDNEMRDFSLLVN 485
                              :||.|             ..:.|::..|.| |.:.|.|.::...:..
  Rat   533 SSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESSREERSVAGKENNADPDQEKKEEKGVSE 597

  Fly   486 RVHVELQRTQEELESQGHESRQRLSSRSHTEG---GESGGDEVHEMLHSHSEEYTNKQMNFAGEL 547
            :...|:. ..|..|:..||..:........|.   ||...||        |:..::::.|:..:|
  Rat   598 KESSEVD-VDENQEASDHEDEEDEEEEDEEEDDIEGEESSDE--------SDSESDEKANYQADL 653

  Fly   548 RNINRQLDLKQELHERIMRNFSRLDS--DDEDVKLRLCNQKIDDLEAERRDLMDQLRNIK--SKD 608
            .||..::.:||:|.:.:..:..||.:  ...:.||.:...||.|.:.||..::..|.:::  |::
  Rat   654 ANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEE 718

  Fly   609 ISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAM 673
            .:.|:..|..|:|..:.:|:..|:......|.|||.:.:..::::.|..::..||::||:|::.|
  Rat   719 KAKKVKCEYEKKLHAMNKELQRLQTAQKEHARLLKNQSQYEKQLKKLQQDVTEMKKTKVRLMKQM 783

  Fly   674 RGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALE 738
            :.|.||.|..:..|.:|:.|||...||...::...:.....|..||:||.||..|..::::...:
  Rat   784 KEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSD 848

  Fly   739 RQASAQAQRHKYKDNGGSAAGSSNANAKTDS---------------------------------- 769
            :.|....::....::....||||..:.:.|:
  Rat   849 KVAGKVTRKLSSSESPTPDAGSSVTSGEADASRPGTQQKMRIPVARVQALPTPTTNGTRKRYQRK 913

  Fly   770 ---------------W--VDREL-EII---LSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDP 813
                           |  ::|.: |||   :::.:.|..:.:|:..|..:......|.:.:....
  Rat   914 GFTGRVFTSKTARMKWQLLERRVTEIIMQKMTISNMEADMNRLLRQREELTKRREKLSKRREKIA 978

  Fly   814 AEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLV 878
            .|:.|..:.|.::.||:|...|.|..:...:  .|..:.|..:.|..:. ||:..|      |.|
  Rat   979 KESGEGDKNLVNISEEMESLTANIDYINDSI--ADCQANIMQMEEAKEE-GETLDV------TAV 1034

  Fly   879 QQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEE-------------QMLAQ 930
                :.|.:|.|.|..||...:..::...|......::::|:.:.::             .||.:
  Rat  1035 ----INACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKE 1095

  Fly   931 QRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELL----SSREALQQELDKLRAKNKSKSK 991
            :.....::..|:..|.|....|  |.||::.:...:..|    |....|..:|.||..:.|.|:|
  Rat  1096 KAELNPELDALLGNALQDLDSA--PLEDEEDSSEEDGPLHSPGSEGSTLSSDLMKLCGEVKPKNK 1158

  Fly   992 A-----------------VKSEPQDLDDSF-----QIVDGNETVVLSDVSDDPDWVPSTSKSKRI 1034
            |                 |.|:....|.|.     .:.:|.||.:.::.|     |||....:
  Rat  1159 ARRRTTTQMELLYADSSEVASDTSAGDASLPGPLTPVAEGQETGMNTETS-----VPSARDKE-- 1216

  Fly  1035 QSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACS 1099
                   :.||......:.|:......|...........|.|..:...|..||.  ....::..|
  Rat  1217 -------LLPPSGLPPKIGSISRQPSVSEKKVPEPSPVTRRKAYEKADKAKTKE--QKHSDSGAS 1272

  Fly  1100 ETCVC-----KSNCRNPLNLKDH--ASQCGDGDGQKDETEDADKS 1137
            ||.:.     .|..||.||:.:.  .|| |....|:|:::::|.|
  Rat  1273 ETSLSPPSSPPSRPRNELNVFNRLTVSQ-GSAPVQQDKSDESDPS 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	155/359 (43%)
		Kinesin	14..335	CDD:278646	154/357 (43%)
		Smc	<396..>994	CDD:224117	145/768 (19%)
		FlaC	522..633	CDD:225888	27/114 (24%)
		TCR	1075..1110	CDD:281618	8/39 (21%)
Kif21a	XP_038934825.1	KISc_KIF4	18..376	CDD:276823	155/359 (43%)
		SbcC	348..1030	CDD:223496	149/696 (21%)
		SMC_prok_B	<649..>852	CDD:274008	53/202 (26%)
		Rcc_KIF21A	942..1023	CDD:410204	15/82 (18%)
		WD40	1346..1659	CDD:238121
		WD40 repeat	1397..1456	CDD:293791
		WD40 repeat	1462..1497	CDD:293791
		WD40 repeat	1502..1546	CDD:293791
		WD40 repeat	1554..1587	CDD:293791
		WD40 repeat	1594..1630	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820