DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Kif4b

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	XP_017449986.2	Gene:	Kif4b / 299255	RGDID:	1564044	Length:	1224	Species:	Rattus norvegicus

Alignment Length:	1269	Identity:	430/1269 - (33%)
Similarity:	640/1269 - (50%)	Gaps:	224/1269 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            |.||||.||||..|:..||::.:. ...|.|||.:..::|:||::|||....|:::|.|.|...:
  Rat    10 VRVALRCRPLVPKEIGEGCQVCLS-FVPGKPQVVIGTDKSFTYDFVFDPSTEQEEVFNTAVAPLI 73

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH--VGVIPRAVHDIFTAIAEMQ-SEFRFAV 135
            |.:..|||.|:||||||||||||:||.|:....:|.  :|||||.:..:|..:.|.: |||...|
  Rat    74 KGIFKGYNATVLAYGQTGSGKTYSMGGAYRANQEDEPTIGVIPRVIQLLFKEMEEKRDSEFTLRV 138

  Fly   136 TCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAV 199
              |::|:|.|:..||..|.....:.:.||| .|..|...||||..|:.|..:...|.:|:..|.|
  Rat   139 --SYLEIYNEEILDLLCSSCEKASQIHIREDPKAGIKTVGLTEKTVSVASDMVSCLEQGNNARTV 201

  Fly   200 AATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINK 264
            ||||||..|||||||||:.:...|...|.|...|:..|||||||||..||.|.|||.:||:|||:
  Rat   202 AATAMNSQSSRSHAIFTVFIRQRKKTDKSSSFHSKLCLVDLAGSERQKKTKAEGDRLREGININR 266

  Fly   265 GLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYA 329
            |||.|||||:|||.|:...::|||.|||||||||||||||.|||||||||||.::.|||:|||||
  Rat   267 GLLCLGNVISALGDGKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSSLEETLNTLRYA 331

  Fly   330 DRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS--GGKMSSSLISAVGAAGLGAIPCEESL 392
            |||.:|||:||:|.||..||:..||..:|:|||.||.  ||.:..|:|         |.|.|
  Rat   332 DRARKIKNEPVINTDPQTAELTHLKHQVQQLRVLLLQAHGGSLPGSII---------AEPSE--- 384

  Fly   393 AGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKN- 456
                    .:|.|.|:.::|.:.|.||...|.::.....:...|..:.|||:::|.:.:.||.:
  Rat   385 --------SLQSLMEKNQSLGEENEKLSHALSEAAGQTAQMLERIILTEQANEQLNTKLQELSDH 441

  Fly   457 ---KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHV--ELQR--------------TQEELESQ- 501
               |:|.::..:     |..|.|      |:.::.:  .||:              :..|||:|
  Rat   442 VACKVDLQKLTE-----TLEDQE------LIEKIEIIRSLQQAVIHLSDENVVATESAMELETQV 495

  Fly   502 GHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMR 566
            ....:.|.||.:.|                  .::..:|...:.||..:|:.|.:|:.|..:|..
  Rat   496 AISPKSRRSSDALT------------------TQHALRQAQMSKELTELNKALAVKEALARKITF 542

  Fly   567 NFSRLD--SDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEIS 629
            |..:|.  ....:|.:|....::..|:.|:..|:..|:..|.....|||.|.|||.||.||.:|:
  Rat   543 NGGQLQPIHCQYEVNIRSLESEVASLQKEKEQLLLDLQLAKKDANQAKLGEHRRKCLQELEAQIA 607

  Fly   630 DLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQL 694
            ||::||..|:.|||:::.....:..|:.||:.||..:|:|:|.|:.::||.||||..::||:.||
  Rat   608 DLKKKLSEQSKLLKLKESTENTVSKLTLEIQMMKTQRVQLMRQMKEDAEKSRQWKQQKDKEVIQL 672

  Fly   695 KSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAG 759
            :.:|||.:.|:::.:....||..||:||.|||.||||||||||::|..| |.:.|...|    .|
  Rat   673 REQDRKRRYELLKLERDFQKQSNVLRRKTEEAAAANKRLKDALQKQRDA-ADKRKETQN----RG 732

  Fly   760 SSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEK--------------- 809
            .....|:..:|:..|:|:::|..|.:|.|..|:|:|.::......|::.|
  Rat   733 LEGTEARVKNWLSNEIEVMVSTEDVKHHLNDLLEERKILALDMAQLKENKEPGENPPLKLQKWTF 797

  Fly   810 --------TSDPAEA-AEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGE 865
                    :|:|.:: .:|.|   |||.|:|:|||||:|||||:...:.:.|.:...|.:.::.|
  Rat   798 ASDEVCGHSSEPEDSITKQIR---SLEAEMELRNAQIADLQQKLLDAESEDRPKRHWESIATVLE 859

  Fly   866 SRTVSKQLLKTLVQQ-----------RRLQASSLNEQRTTLD----------ELRAQLLDAQQQE 909
            ::...|.|:..:|..           ::.|||....|:..|:          |.:|:|..|:|:.
  Rat   860 AKCALKYLVGEVVSSKLQVSELESNLKQSQASHSKTQKMLLEEQSHLVQVEAEWKAELSKAEQKH 924

  Fly   910 DAASKRLRLLQSQHEEQMLAQQRAYEEKVSV------LIRTANQRWAEARSPAEDQQRNQILEEL 968
            .  .|.|.|| ||.::..:|:||.   :|||      |:.|...:..:.|...|..::||   :|
  Rat   925 Q--EKELYLL-SQLQQSQMAEQRL---EVSVSGKEQQLLSTLQCQEDQFRKMQELCEQNQ---QL 980

  Fly   969 LSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKR 1033
            |...||::|:|...:.....||...:.:.|..|.||                  :::|...|:.|
  Rat   981 LQENEAIRQKLSLFQGTKDQKSHLPRDDLQSPDSSF------------------NYIPPPPKASR 1027

  Fly  1034 IQS-------DSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDG-----------------KR 1074
            ::.       |..::.|.||                 .|.|.:|||                 |.
  Rat  1028 VRGKFLDQSMDIDDLNSYPE-----------------YSMSESEDGDGHDKEWKPRKLAKVSRKT 1075

  Fly  1075 CKGCKCRTKCTTKRCGCLSGNNACSETCVC-KSNCRNPLNLKDHASQCGDGDGQKDETEDADKSD 1138
            .:||.|:..|..|.|||......|...|.| .:.||   |.:......|..:..:| :|.:.|.|
  Rat  1076 FQGCSCKGWCRNKHCGCRKQGVDCCVACGCDPTKCR---NRQQEQESLGTVEWNQD-SEVSFKLD 1136

  Fly  1139 DDGDDEPQTSKENAVKFVTPEAPGKVVASPKQTL 1172
            |..:..|      .:.|..|     |.|:|...|
  Rat  1137 DPTEVTP------GLSFFNP-----VCATPNTKL 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	171/330 (52%)
		Kinesin	14..335	CDD:278646	167/324 (52%)
		Smc	<396..>994	CDD:224117	190/671 (28%)
		FlaC	522..633	CDD:225888	31/112 (28%)
		TCR	1075..1110	CDD:281618	12/35 (34%)
Kif4b	XP_017449986.2	KISc_KIF4	8..338	CDD:276823	171/330 (52%)
		Smc	<370..742	CDD:224117	124/425 (29%)
		SMC_prok_B	<594..923	CDD:274008	111/336 (33%)
		SET	1074..>1113	CDD:394802	14/41 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010