Protein Alignment Klp3A and klp5

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_595703.1
• Gene: klp5 / 2540361
• PomBaseID: SPBC2F12.13
• Length: 883
• Species: Schizosaccharomyces pombe
• Alignment Length: 951
• Identity: 222/951 - (23%)
• Similarity: 389/951 - (40%)
• Gaps: 250/951 - (26%)

  Fly    45 RNESYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH 109
            |:..|.::.|||...:|:.::|...:..:..:|:|:|.||.|||.||.|||:|:    :|.:.|
pombe   101 RDLRYAFDRVFDETATQQQVYERTARPLLDNILDGFNATIFAYGATGCGKTHTI----SGTMQD- 160

  Fly   110 VGVIPRAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKA-TVDIRE-VKNRIIM 172
            .|:|...:.::|..:..::.|..|.:..|::|:|.|...||..|.|.::| .:::|| ...||.:
pombe   161 PGLIYLTLKELFERMDHLRDEKIFDLRLSYLEIYNETIRDLLVSPTPNQAKPLNLREDADRRITV 225

  Fly   173 PGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDG--KQSVTTSRF 235
            ||||.|...|.:::.|.:::|:|.|.::.|..|..||||||:..:||:......  .:..|.:..
pombe   226 PGLTSLSPESLEEIIDIIMKGNANRTMSPTEANAASSRSHAVLQVTLIQKPRTAGINEDHTLATL 290

  Fly   236 NLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSL 300
            :::|||||||.:.|...|.|..||.||||.||||||.||||.......::|||.|||||||:.||
pombe   291 SIIDLAGSERATATKLRGSRLFEGANINKSLLALGNCINALCDPHRRAHVPYRDSKLTRLLKFSL 355

  Fly   301 GGNSITLMIACVSPADYNVAETLSTLRYADRALQIKN---KPVVNLDPHAAEVNMLKDVIQKLRV 362
            |||..|:||.||||:..:..||.:||:||:||..||.   :.::::|.|.::  .:|.:::
pombe   356 GGNCRTVMIVCVSPSSVHYEETHNTLKYANRAKNIKTEVLRNMISVDRHVSQ--YVKAIVE---- 414

  Fly   363 ELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSL 427
                                                                             
pombe   415 ----------------------------------------------------------------- 414

  Fly   428 LDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQ 492
                               ||..:|||:|:|
pombe   415 -------------------LREQISELENRL---------------------------------- 426

  Fly   493 RTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEE---YTNKQMNFAGELRNIN--- 551
             .|.:|.||.:.|.|...::|...  ||...|...:|....||   ..|..:|...::::.:
pombe   427 -AQIDLSSQSNGSDQDAVTQSFAH--ESKLAEARNLLRMTFEETLPLQNDTINKVEKVKHFDDSI 488

  Fly   552 RQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEE 616
            |.|......:|||:.|     |.||  ::.|...|::.|...|.:::        .||..:|..:
pombe   489 RVLKYWLSCYERILPN-----SADE--RVFLVRSKLESLLTRRAEII--------ADIDPELVYQ 538

  Fly   617 RRKR-----------------LQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKE 664
            :.:|                 ..:|:.|: ||.:.:|..    ::.|.: .|:...:..:.::..
pombe   539 KFQRSVSHIINTYKQEGATMYADVLQDEV-DLLKSIIEN----QVLDAQ-NKVDEFTPVLESLLR 597

  Fly   665 SKVKLIRAMR--GESEKF---RQWKM---VREKELTQLKSKDRKM-----QSEIVRQQTLHSKQR 716
            |..|....::  |..|.|   .:|.:   :.||....:.|:..|:     .|..:.:..:||...
pombe   598 SSFKASSLLKEGGMQELFSILEKWLLGIGLGEKPNISVLSESYKLNSTSDDSRTINRDRVHSFPT 662

  Fly   717 QVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDN-GGSAAGSSNANAKTDSWVDRELEIILS 780
            |.|.......:...|..|..:.....:..:|.::.|: ..|.:|:|..|:...:...:.:....:
pombe   663 QPLLNNNLPRMFFVKSPKKPVVFSKRSPKKRVRFDDSMSTSDSGASAYNSPIQTSKLKNMNFFNT 727

  Fly   781 L----------------IDAEHSL----EQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILA- 824
            :                ||.|.:|    ..::||:...........::|....:|:.:..::||
pombe   728 MHMPSTPAHKRPENKNQIDVEINLTSPVSPMLEDKPEPGLLIKSPLEKKQEVNSESTQLDQLLAE 792

  Fly   825 -SLEEELEMRNAQISDLQQKVCP---------TDLDSRIRSL-AEGVQSLGESRTVSKQLLKTLV 878
             |..:::.:.:....||.....|         .::||....| .|.:.:...|:..::|.|.:|
pombe   793 DSSTDDVSLPHLDTIDLDGSPVPKVPDLNFSRANMDSPTFILNNEAIHNFDFSKPKTRQSLSSL- 856

  Fly   879 QQRRLQASSLNEQRTTL------DELRAQLLDAQQQEDAAS 913
                          |||      :.:|..|..|:.:|:.|:
pombe   857 --------------TTLHLSNPANIIRKSLSMAENEEEKAT 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	118/294 (40%)
		Smc	<453..>985	CDD:440809	96/536 (18%)
		Metallothio	<1071..1115	CDD:395080
klp5	NP_595703.1	KISc_KIP3_like	6..390	CDD:276821	118/293 (40%)