DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klp3A and KIF4A

DIOPT Version :10

Sequence 1:NP_525053.1 Gene:Klp3A / 31240 FlyBaseID:FBgn0011606 Length:1212 Species:Drosophila melanogaster
Sequence 2:NP_036442.3 Gene:KIF4A / 24137 HGNCID:13339 Length:1232 Species:Homo sapiens


Alignment Length:1319 Identity:456/1319 - (34%)
Similarity:678/1319 - (51%) Gaps:222/1319 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            |.||||.||||..|:..||::.:. ...|.|||.|..::|:||::|||....|:::|.|.|...:
Human    10 VRVALRCRPLVPKEISEGCQMCLS-FVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVFNTAVAPLI 73

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH--VGVIPRAVHDIFTAIAEMQSEFRFAVT 136
            |.:..|||.|:||||||||||||:||.|:....::.  ||||||.:..:|..| :.:|:|.|.:.
Human    74 KGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEI-DKKSDFEFTLK 137

  Fly   137 CSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVA 200
            .|::|:|.|:..||. ..:|:||.::||| .|..|.:.||||..|..|......|.:|:..|.||
Human   138 VSYLEIYNEEILDLL-CPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVA 201

  Fly   201 ATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKG 265
            :||||..|||||||||::|...|...|.|...|:.:|||||||||..||.|.|||.|||:|||:|
Human   202 STAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRG 266

  Fly   266 LLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYAD 330
            ||.|||||:|||..:..|::|||.|||||||||||||||.|||||||||||.|:.|||:||||||
Human   267 LLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYAD 331

  Fly   331 RALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS--GGKMSSSLISAVGAAGLGAIPCEESLA 393
            ||.:|||||:||:||..||:|.||..:|:|:|.||.  ||.:.            |:|..|.|  
Human   332 RARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLP------------GSITVEPS-- 382

  Fly   394 GSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKN-- 456
                  ..:|.|.|:.::|.:.|.||.:.|.::.....:...|..:.|||::|:.:.:.||:.  
Human   383 ------ENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHA 441

  Fly   457 --KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQ-GHESRQRLSSRSHTEGG 518
              |||.::..:     |..|.|:::        :||:....::|.:| ..|:...:::...|...
Human   442 ACKLDLQKLVE-----TLEDQELKE--------NVEIICNLQQLITQLSDETVACMAAAIDTAVE 493

  Fly   519 ESGGDEVHEMLHSHSEEYTN----KQMNFAGELRNINRQLDLKQELHERIMRNFSRLDS-----D 574
            :....|........|:.:|.    :|...:.||..:|:.|.||:.|..::.:|.|:|..     .
Human   494 QEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQ 558

  Fly   575 DEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQA 639
            |...:|.|   ::.:|:.|:.:|:.:|:..|.....|||:|.||||||.||.:|:||::||..|:
Human   559 DNIKELEL---EVINLQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQS 620

  Fly   640 NLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSE 704
            .|||:::.....:..|:.|||.||..:|:|:|.|:.::|||||||..::||:.|||.:|||.|.|
Human   621 KLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYE 685

  Fly   705 IVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNG--GSAAGSSNANAKT 767
            :::.:....||..||:||.|||.||||||||||::|.....:|.:.:..|  |:|       |:.
Human   686 LLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTA-------ARV 743

  Fly   768 DSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTS--DP----------------- 813
            .:|:..|:|:::|..:|:..|..|:|||.::......|:::|.|  :|                 
Human   744 KNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQ 808

  Fly   814 -AEAAEQ-ARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKT 876
             :|:.:. .:.:.|||.|:|.|:|||:|||||:...:.:.|.:...|.:.::.|::...|.|:..
Human   809 VSESEDSITKQIESLETEMEFRSAQIADLQQKLLDAESEDRPKQRWENIATILEAKCALKYLIGE 873

  Fly   877 LV----QQRRLQASSLNEQRTTL------------------DELRAQLLDAQQQEDAASKRLRLL 919
            ||    |..:|: |||.:.:|:.                  .||:|:|:..:||..  .|.|.||
Human   874 LVSSKIQVSKLE-SSLKQSKTSCADMQKMLFEERNHFAEIETELQAELVRMEQQHQ--EKVLYLL 935

  Fly   920 QSQHEEQMLAQQ--RAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKL 982
            ....:.||..:|  .:..||...|:.|...:..|.....|..::||   :||...|.::|:|..|
Human   936 SQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEKMREVCEQNQ---QLLRENEIIKQKLTLL 997

  Fly   983 RAKNKSKSKAVKSEPQDL----DDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVIS 1043
            :..::.|..     |:|.    |.||:.|             .|...||..|.|.::        
Human   998 QVASRQKHL-----PKDTLLSPDSSFEYV-------------PPKPKPSRVKEKFLE-------- 1036

  Fly  1044 PPEKQDANVTSLGNSSIQSLNSTSATEDG----------------------KRCKGCKCRTKCTT 1086
                |..::..|...|..|:|.   .|||                      |..:||.|:..|..
Human  1037 ----QSMDIEDLKYCSEHSVNE---HEDGDGDDDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGN 1094

  Fly  1087 KRCGCLSGNNACSETCVC-KSNCRNPLNLKDHASQCGDGDGQKDETEDAD---KSDDDGDDEPQT 1147
            |:|||....:.|...|.| .:.|||       ..|..|..|..:.|:|::   |.:|..:..|..
Human  1095 KQCGCRKQKSDCGVDCCCDPTKCRN-------RQQGKDSLGTVERTQDSEGSFKLEDPTEVTPGL 1152

  Fly  1148 SKENAV------KFV-------------TPEAPGKVVASPKQTLQEPKAAATPLMNSNVVEDING 1193
            |..|.|      |.:             ||.||     ||.. |.|.|..||.      .::...
Human  1153 SFFNPVCATPNSKILKEMCDVEQVLSKKTPPAP-----SPFD-LPELKHVATE------YQENKA 1205

  Fly  1194 PKLAKMSGLAFDTPKRKFF 1212
            |...|...||.:|   .||
Human  1206 PGKKKKRALASNT---SFF 1221

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp3ANP_525053.1 KISc_KIF4 7..336 CDD:276823 175/329 (53%)
Smc <453..>985 CDD:440809 178/592 (30%)
Metallothio <1071..1115 CDD:395080 17/66 (26%)
KIF4ANP_036442.3 KISc_KIF4 8..337 CDD:276823 175/329 (53%)
PRK11281 383..>646 CDD:481316 76/278 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..515 3/18 (17%)
Smc <517..>1033 CDD:440809 172/549 (31%)
Required for the interaction with PRC1. /evidence=ECO:0000269|PubMed:15297875 663..1232 172/627 (27%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:11736643 793..798 0/4 (0%)
Globular 1000..1232 65/277 (23%)
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000269|PubMed:29848660 1086..1144 19/64 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1142 5/19 (26%)

Return to query results.
Submit another query.