Protein Alignment Klp3A and KIF13B

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_011542759.1
• Gene: KIF13B / 23303
• HGNCID: 14405
• Length: 1847
• Species: Homo sapiens
• Alignment Length: 1377
• Identity: 337/1377 - (24%)
• Similarity: 544/1377 - (39%)
• Gaps: 363/1377 - (26%)

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNES----------YTYNYVF-DIDDS 60
            |.|.||:|:||:.:.|.|...:..|:..|:......||.|.|          :.|::.| .:|:|
Human     4 SKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSMDES 68

  Fly    61 QK------DLFETCVQAKV-KKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAV 117
            .|      |:...|:...: :...:|||..|.|||||||||:|| ||||      |..|:|||..
Human    69 VKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTA------DQPGLIPRLC 127

  Fly   118 HDIFTAIAEMQSEFR-FAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTEL 178
            ..:|....:.::|.: |.|..|::|:|.|:..||...| ..:.|:.:||  :.::.|   ||::|
Human   128 SGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPK-GSRQTLKVRE--HSVLGPYVDGLSKL 189

  Fly   179 VVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVT---TSRFNLVDL 240
            .|||.:.:...:..|:..|.||||.|||.||||||:|.:||..|..|.|...:   ..:.:||||
Human   190 AVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDL 254

  Fly   241 AGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAG-----YIPYRQSKLTRLLQDSL 300
            |||||.:||.|:|||.|||.||||.|..||.||:|| :.|:||     ::|||.|.||.||:|||
Human   255 AGSERATKTGAAGDRLKEGSNINKSLTTLGLVISAL-ADQSAGKNKNKFVPYRDSVLTWLLKDSL 318

  Fly   301 GGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELL 365
            ||||.|.|:|.||||..|..||||||||||||..|.|..|||.||:|..:..|::.::|||.:|.
Human   319 GGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLT 383

  Fly   366 SGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDL 430
            ....|.|..:.                          .||:|..:.:|:.....:::|.:
Human   384 KAEAMKSPELK--------------------------DRLEESEKLIQEMTVTWEEKLRK----- 417

  Fly   431 TEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNE-----NTNGDNEMRDFSLLVNRVHVE 490
            ||:     ||::...:|.|....|     |....:.|::     |.|.|..:.:..:...:.|..
Human   418 TEE-----IAQERQKQLESLGISL-----QSSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTL 472

  Fly   491 L-QRTQEELESQG-------------HESRQRLSSRSHTE---GGESGGDEVHEMLHSHSEEYTN 538
            : ....::::..|             .|.:..|:.:.:|.   .|.|....:  .||........
Human   473 IGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPI--QLHHGDRILWG 535

  Fly   539 KQMNFAGELRNINRQLDLKQELHERIMRN---FSRLDSDDE---DVKLRL-CNQKIDDLEAERRD 596
            ....|...|....::.:.:.|..:..|:|   ..:||.|.:   :|...: .|.:...:|...:.
Human   536 NNHFFRLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKA 600

  Fly   597 L--MDQLRNIKSKDISAKLAEERRKRLQ----LLEQEISDLRRKLITQANLLKIRDKEREKIQNL 655
            |  .|.:::|.: .:..:..||:|..|:    :.|.|:..|||:|..:..  ..|..:|....:.
Human   601 LGSNDPMQSILN-SLEQQHEEEKRSALERQRLMYEHELEQLRRRLSPEKQ--NCRSMDRFSFHSP 662

  Fly   656 STEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLK 720
            |.:                   ::.|||...||                    .||::.    |.
Human   663 SAQ-------------------QRLRQWAEERE--------------------ATLNNS----LM 684

  Fly   721 RKCEEALAANKRLKDALERQASAQAQ----RHKYKDNGGSAAGSSNANAKTDS------------ 769
            |..|:.:.||     .|.|:|:..|:    |.:||......|.|.:||.|..|
Human   685 RLREQIVKAN-----LLVREANYIAEELDKRTEYKVTLQIPASSLDANRKRGSLLSEPAIQVRRK 744

  Fly   770 ------WVDRELE-IILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLE 827
                  |...:|: .:|.:.|.....::..||..||.:::      |.:||....::...|
Human   745 GKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVIRSYF------KRADPFYDEQENHSL---- 799

  Fly   828 EELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQR 892
              :.:.|..:..|...|          .|...|..:.:...|:.:|   .|:..|| :..:.|:.
Human   800 --IGVANVFLESLFYDV----------KLQYAVPIINQKGEVAGRL---HVEVMRL-SGDVGERI 848

  Fly   893 TTLDELRAQLLDAQQQEDAASKRLRLLQS----QHEEQMLAQQRAY---EEKVSVLIRTANQRWA 950
            ...||:.....:.:.||:.....:::||:    ||....:..:.::   :|.|.|.........:
Human   849 AGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEPVIVAPEVDTSSSS 913

  Fly   951 EARSP----------------AEDQQRNQILEELLSSREALQ---------------QELDKLRA 984
            .::.|                .||     .:|.|.....|::               .:|..::|
Human   914 VSKEPHCMVVFDHCNEFSVNITED-----FIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQA 973

  Fly   985 KNKSKSKAVKSEPQDLDDSFQIVDGN--------ETVVLSDVSDDPDWVPSTSKSKRIQSDSRNV 1041
            |.:|.........:.|:...||::.|        |.:...||.....:.....:|:|:|.:.::|
Human   974 KTRSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQGQSRRVQVEVKSV 1038

  Fly  1042 ISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKS 1106
                  |::....|....|.|:..                                   .||...
Human  1039 ------QESGTLPLMEECILSVGI-----------------------------------GCVKVR 1062

  Fly  1107 NCRNPLNLKDHASQCGDGDGQKDE---------------------------TEDADKSDDDGDDE 1144
            ..|.|...:....:..|.|..:|.                           ....||::||.|.|
Human  1063 PLRAPRTHETFHEEEEDMDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKRDKTEDDADRE 1127

  Fly  1145 PQ--------TSKENAVKFVTPEAPGKVVASPKQTLQEPKAAATPL--MNSN---VVEDINGPKL 1196
            .|        |.:.|||  :.|.|...:..:|        |..||:  |.::   :..|:|....
Human  1128 AQLLEMRLTLTEERNAV--MVPSAGSGIPGAP--------AEWTPVPGMETHIPVIFLDLNADDF 1182

  Fly  1197 AKMSGLAFDTPK 1208
            :....|  |.|:
Human  1183 SSQDNL--DDPE 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	155/359 (43%)
		Smc	<453..>985	CDD:440809	108/627 (17%)
		Metallothio	<1071..1115	CDD:395080	4/43 (9%)
KIF13B	XP_011542759.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	158/365 (43%)
		Kinesin_assoc	357..469	CDD:465047	30/152 (20%)
		FHA_KIF13B	447..545	CDD:438782	13/99 (13%)
		COG4913	<611..>760	CDD:443941	40/199 (20%)
		KIF1B	756..802	CDD:463574	11/57 (19%)
		bMERB_dom	<1099..1143	CDD:463467	8/43 (19%)
		DUF3694	<1221..1278	CDD:463599
		PHA03247	<1445..1704	CDD:223021
		CAP_GLY	1725..1788	CDD:460154