Protein Alignment Klp3A and KIF1B

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001352880.1
• Gene: KIF1B / 23095
• HGNCID: 16636
• Length: 1816
• Species: Homo sapiens
• Alignment Length: 1240
• Identity: 323/1240 - (26%)
• Similarity: 494/1240 - (39%)
• Gaps: 323/1240 - (26%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGA----PQVTVNRNESYTYNYVFDIDDSQKDLFETCV 69
            |.||:||||....|..:..:..::...:..    |:......:|::::|.:....|.:|   .|.
Human     6 VKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPED---PCF 67

  Fly    70 --QAKV-----KKLL----NGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTA 123
              |.:|     |::|    .||||.|.||||||:||:|||   .....:...|:||:...::|..
Human    68 ASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTM---MGKQEESQAGIIPQLCEELFEK 129

  Fly   124 IAE-MQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTELVVTSAQ 184
            |.: ...|..::|..|::|:|.|:..||.:.|  :|..:.:||  :.::.|   .|::|.|||..
Human   130 INDNCNEEMSYSVEVSYMEIYCERVRDLLNPK--NKGNLRVRE--HPLLGPYVEDLSKLAVTSYT 190

  Fly   185 QVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTT---SRFNLVDLAGSERC 246
            .:.|.:..|:..|.||||.||||||||||:||:.....|.|.:.:::|   |:.:|||||||||.
Human   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERA 255

  Fly   247 SKTLASGDRFKEGVNINKGLLALGNVINALG----------SGQAAGYIPYRQSKLTRLLQDSLG 301
            ..|.|.|.|.|||.||||.|..||.||:||.          ..:...:||||.|.||.||:::||
Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   302 GNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELL- 365
            |||.|.|:|.:||||.|..||||||||||||.|||...|:|.||:|..|..||:.:.:|: :||
Human   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLK-DLLR 384

  Fly   366 -------------------SGGK------------------------------------MSSSLI 375
                               ||.|                                    .|.||.
Human   385 AQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLS 449

  Fly   376 SAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIA 440
            |.||...:.:|  :|.:..:......|:||||..:.:.:.|...:::|.::  :....|..|.:|
Human   450 SQVGLTSVTSI--QERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKT--EAIRMEREALLA 510

  Fly   441 EQA-------------HDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLL-----VNRV 487
            |..             ..|...|:                 .|.|.|..|.:..|.     :.||
Human   511 EMGVAIREDGGTLGVFSPKKTPHL-----------------VNLNEDPLMSECLLYYIKDGITRV 558

  Fly   488 -HVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLH--SHSEEYTN-KQMNFAGELR 548
             ..:.:|.|:.:.|..|...:....||  |...||  ||...|.  ..||.|.| |:::...:||
Human   559 GQADAERRQDIVLSGAHIKEEHCIFRS--ERSNSG--EVIVTLEPCERSETYVNGKRVSQPVQLR 619

  Fly   549 NINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKL 613
            :.||.:..|..:........:|.:. ::.......::.:|...|:|..|..|..::|
Human   620 SGNRIIMGKNHVFRFNHPEQARAER-EKTPSAETPSEPVDWTFAQRELLEKQGIDMK-------- 675

  Fly   614 AEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESE 678
             :|..||||  |.||               :..||:|:...|..:.|...|||::.::
Human   676 -QEMEKRLQ--EMEI---------------LYKKEKEEADLLLEQQRLDYESKLQALQ------- 715

  Fly   679 KFRQWKMVREKELTQLKSKDRKMQSEIV-RQQTLHSKQRQVLKRKCEEALAANKRLKDALERQAS 742
                 |.|..:.|....:::.:.:.|:. .|......|....|.|..:..:    |:|.|
Human   716 -----KQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTS----LRDLL----- 766

  Fly   743 AQAQRHKYKDNGGSAAGSSNANAKTDSWVDREL------EIILSLIDAEHS----------LEQL 791
                       .|:|.....|||     :..||      :.:| |.|..:|          :|:.
Human   767 -----------WGNAVYLKEANA-----ISVELKKKVQFQFVL-LTDTLYSPLPPELLPTEMEKT 814

  Fly   792 MEDR-------AVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDL 849
            .|||       ||           :..|....|.....|..|::.|::..             ::
Human   815 HEDRPFPRTVVAV-----------EVQDLKNGATHYWSLEKLKQRLDLMR-------------EM 855

  Fly   850 DSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASS------LNEQ---RT------TLDELR 899
            ..|...:|...|...|:...............:|..||      :||:   ||      |.|...
Human   856 YDRAGEMASSAQDESETTVTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDI 920

  Fly   900 AQLLDAQQQEDAASKRLRLLQSQHEEQML--AQQRAYEEKVSVLIRTANQRWAEARSP------- 955
            .:|.|.||.|         ::...:|..:  |...|..|:.|.|....:..:.: |||
Human   921 TELADEQQDE---------MEDFDDEAFVDDAGSDAGTEEGSDLFSDGHDPFYD-RSPWFILVGR 975

  Fly   956 AEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLD--------DSFQIVDGNET 1012
            |.....|.:....|..|.|:..|..::|...:...:|:.::.:..|        .:.:|...||.
Human   976 AFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEY 1040

  Fly  1013 VVLSDVSDDPDWVPSTSKSKRI--------QSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSAT 1069
            ...||.|.    |..|.....:        |..|..||:|||:         .|.|..|:..|:|
Human  1041 FNQSDFSS----VAMTRSGLSLEELRIVEGQGQSSEVITPPEE---------ISRINDLDLKSST 1092

  Fly  1070 -EDGK 1073
             .|||
Human  1093 LLDGK 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	142/358 (40%)
		Smc	<453..>985	CDD:440809	119/588 (20%)
		Metallothio	<1071..1115	CDD:395080	3/3 (100%)
KIF1B	NP_001352880.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	145/364 (40%)
		Interaction with KIFBP. /evidence=ECO:0000269|PubMed:16225668	270..350		42/79 (53%)
		Kinesin_assoc	358..555	CDD:465047	40/218 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..450		3/18 (17%)
		FHA_KIF1B	530..639	CDD:438779	30/129 (23%)
		GimC	662..>719	CDD:440992	22/94 (23%)
		KIF1B	845..892	CDD:463574	7/59 (12%)
		KIF1B	<956..975	CDD:463574	3/19 (16%)
		DUF3694	1266..1413	CDD:463599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1550..1570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1617..1660
		PH_KIFIA_KIFIB	1697..1799	CDD:269939