DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and KIF21B

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001239029.1	Gene:	KIF21B / 23046	HGNCID:	29442	Length:	1637	Species:	Homo sapiens

Alignment Length:	1369	Identity:	365/1369 - (26%)
Similarity:	606/1369 - (44%)	Gaps:	286/1369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLF 65
            |:.:...||.||:|:||.:..|...||.|... ...|.|||.:.:::::||::|||:|..|:.::
Human     1 MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTS-VTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIY 64

  Fly    66 ETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFN-GVLDDHVGVIPRAVHDIFTAIAEMQS 129
            .|||...::....|||.|:|||||||:||||||||.|: ...::..|:||||:..:|..|||.:.
Human    65 STCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMATSEEEQGIIPRAIAHLFGGIAERKR 129

  Fly   130 EFR--------FAVTCSFVELYQEQFYDLFSSKTRD------KATVDIREVKN-RIIMPGLTELV 179
            ..:        |.|:..|:|||.|:..|||.| |||      ::.:.|.|..| .|...|:|..:
Human   130 RAQEQGVAGPEFKVSAQFLELYNEEILDLFDS-TRDPDTRHRRSNIKIHEDANGGIYTTGVTSRL 193

  Fly   180 VTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKL---------------DG--- 226
            :.|.:::...|.:|:..|..|:|.||..|||||||||:.|...::               ||
Human   194 IHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDGTPP 258

  Fly   227 --KQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYR 288
              :....|::|:.||||||||..:|.|:|:|.|||::||.|||||||||:||| ..:...::|||
Human   259 SSEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYR 323

  Fly   289 QSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNML 353
            .|||||||||||||||.|:|||||||:|.:..|||:||:||:||..||||.|||.|..:.:::.|
Human   324 DSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISAL 388

  Fly   354 KDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAA---EIQRLKEQVRTLQDR 415
            :..|.:|::||:. .|....:|...||.|...:..|.::. ...|.|   .::.::|.:..:.:|
Human   389 RAEIARLQMELME-YKAGKRVIGEDGAEGYSDLFRENAML-QKENGALRLRVKAMQEAIDAINNR 451

  Fly   416 NRKLQQELHQSLL----DLTE-------------KEMRAHI--AEQAHDKLRSHVSELKNKLDQR 461
            ..:|..:....||    |..|             :|:|..:  :|..::.||..:|....:....
Human   452 VTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARSPYS 516

  Fly   462 EQAQ-----FGNENTNGDNEMRDFSLLVNRVHVELQRTQEE--------LESQGHESRQRLSSRS 513
            ..|.     ||....   :.|.|.|.::.|...:|:|.:::        .|.:..:.|.:|...:
Human   517 LGASPAAPAFGGSPA---SSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQEN 578

  Fly   514 HTEGGESGGDEVHE-------------------------MLHSHSEEYTNKQMNFAGELRNINRQ 553
            ..|..|:..:|..|                         ::.|.|:. ..|::||..:|.::..:
Human   579 SEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDP-EEKEVNFQADLADLTCE 642

  Fly   554 LDLKQELHERIMRNFSRLDS--DDEDVKLRLCNQKIDDLEAERRDLMDQLRNIK--SKDISAKLA 614
            :::||:|.:.:..:..||.:  ...:.||.|...||.|.:.||..::..|..::  :::.:.|:.
Human   643 IEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIK 707

  Fly   615 EERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEK 679
            .:..|||:.:.:::..|:......|.|||.:.:...:::.|..|:..||::||.|::.||.|.::
Human   708 ADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKVALMKQMREEQQR 772

  Fly   680 FRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQA--- 741
            .|..:..|.:|:.|||.:.|:.:.:|...::...:|..||:||.:|..|..:..|...||.|
Human   773 RRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEMVLRRKTQEVSALRRLAKPMSERVAGRA 837

  Fly   742 ------------------SAQAQ-----------------------------------RHKYKDN 753
                              |::|:                                   |.|::..
Human   838 GLKPPMLDSGAEVSASTTSSEAESGARSVSSIVRQWNRKINHFLGDHPAPTVNGTRPARKKFQKK 902

  Fly   754 GGSAAGSSNANAKTDSWVDRELEII---LSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAE 815
            |.|.:.|..|..|..|...|.::|:   :::::.|..:|:|::.|..:......|::::....||
Human   903 GASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAE 967

  Fly   816 AAEQARILASLEEELEMR-------NAQISDLQQKV-----CPTDLDSRIRSLAEGVQSLGESRT 868
            :.|:.:.|..|.||:|:.       |..|:|.|..:     ...:|||...|:.....||.|:|.
Human   968 SPEEEKGLQELAEEIEVLAANIDYINDGITDCQATIVQLEETKEELDSTDTSVVISSCSLAEARL 1032

  Fly   869 VSKQLLKTLV----------------------------QQRRLQASSLNEQRTTLDELRAQLLDA 905
            :....||..:                            .|..|...:|.|:.....||:|.:.:.
Human  1033 LLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMAGSSQNHLLLDALREKAEAHPELQALIYNV 1097

  Fly   906 QQQEDAASKRLRLLQSQHEEQMLAQQRAY-------------EEKVSVLIRTANQRWAEARSPAE 957
            ||:...||....:  |:..|...:|....             |.|:|..::..:   ||...|..
Human  1098 QQENGYASTDEEI--SEFSEGSFSQSFTMKGSTSHDDFKFKSEPKLSAQMKAVS---AECLGPPL 1157

  Fly   958 DQQRNQILEELLSSREALQQELD----------------KLRAKNKS---KSKAVKSEPQDLDDS 1003
            |.....|.:.|.|..|..:..:.                .|..:..:   :|:|.::.|.....|
Human  1158 DISTKNITKSLASLVEIKEDGVGFSVRDPYYRDRVSRTVSLPTRGSTFPRQSRATETSPLTRRKS 1222

  Fly  1004 FQIVDGNETVVLSDVSDDPDWVPST--------------------SKSKRIQSDS------RNVI 1042
            :   |..:.:..:||...|...|.|                    :..|...|||      |.:|
Human  1223 Y---DRGQPIRSTDVGFTPPSSPPTRPRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGII 1284

  Fly  1043 SP------PEKQDANVTSLGNSSIQSLNSTSATED----GKRCKGCKCRTKCTTKRCGCLSG--N 1095
            ||      .........|:.....:.:....||::    |.:.:.||.....|.:....|.|  |
Human  1285 SPVGGAKGARTAPLQCVSMAEGHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPN 1349

  Fly  1096 NACS 1099
            |..|
Human  1350 NVVS 1353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	161/365 (44%)
		Kinesin	14..335	CDD:278646	157/357 (44%)
		Smc	<396..>994	CDD:224117	156/792 (20%)
		FlaC	522..633	CDD:225888	27/139 (19%)
		TCR	1075..1110	CDD:281618	8/27 (30%)
KIF21B	NP_001239029.1	KISc_KIF4	7..371	CDD:276823	161/365 (44%)
		KISc	9..377	CDD:214526	165/369 (45%)
		Interaction with TRIM3. /evidence=ECO:0000250\|UniProtKB:Q9QXL1	400..1099		141/704 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..538		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..628		9/76 (12%)
		PKK	660..794	CDD:289257	36/133 (27%)
		JAKMIP_CC3	678..806	CDD:292653	32/127 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..865		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..906		3/25 (12%)
		Prefoldin	954..1102	CDD:298833	32/147 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1194..1251		11/59 (19%)
		WD40	1305..1613	CDD:238121	11/49 (22%)
		WD40	1306..>1614	CDD:225201	11/48 (23%)
		WD 1	1306..1343		6/36 (17%)
		WD40 repeat	1312..1346	CDD:293791	7/33 (21%)
		WD 2	1346..1384		4/8 (50%)
		WD40 repeat	1351..1387	CDD:293791	1/3 (33%)
		WD40 repeat	1407..1450	CDD:293791
		WD 3	1410..1448
		WD 4	1451..1493
		WD40 repeat	1456..1500	CDD:293791
		WD 5	1502..1539
		WD40 repeat	1509..1541	CDD:293791
		WD 6	1543..1582
		WD40 repeat	1548..1572	CDD:293791
		WD 7	1585..1622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720