Protein Alignment Klp3A and Kif18a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001405889.1
• Gene: Kif18a / 228421
• MGIID: 2446977
• Length: 919
• Species: Mus musculus
• Alignment Length: 827
• Identity: 225/827 - (27%)
• Similarity: 380/827 - (45%)
• Gaps: 164/827 - (19%)

  Fly    44 NRNESYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLD 107
            |::..:.::.|||...:|.::||...:..:...|||||.|:.|||.||||||:|| |:|
Mouse    69 NKDLKFVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSA------ 127

  Fly   108 DHVGVIPRAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR-II 171
            ...||:...:.|:|..|.|::.|...:...|::|:|.||..||.:    :...:.:||...: ::
Mouse   128 AEPGVMYLTMLDLFKCIDEIKEEKECSTAVSYLEVYNEQIRDLLT----NSGPLAVREDSQKGVV 188

  Fly   172 MPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGK-----QSVT 231
            :.|||.....|::::...|..|:..|....|.:|..||||||:|.:.|   :...|     |:|.
Mouse   189 VQGLTLHQPKSSEEILQLLDNGNKNRTQHPTDVNAVSSRSHAVFQIYL---RQQDKTASINQNVR 250

  Fly   232 TSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAG-YIPYRQSKLTRL 295
            .::.:|:|||||||.|.:.|.|.||.||.||||.|||||||||||.:.:... :||||.||||||
Mouse   251 IAKMSLIDLAGSERASVSGAKGSRFVEGTNINKSLLALGNVINALANTKRRNQHIPYRNSKLTRL 315

  Fly   296 LQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKN---KPVVNLDPHAAE----VNML 353
            |:||||||..|:|||.|||:.....:|.:||:||:||.:||:   ..|:||:.|.::    .||.
Mouse   316 LKDSLGGNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNSHISQYVKICNMQ 380

  Fly   354 KDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRK 418
            |..|..|: |.|...:...:|......|         .|..|.....|.:|.:|.:..|......
Mouse   381 KAEILMLK-EKLKAYEEQKALSDRNDCA---------KLVHSNPEDRETERFQEILNCLFQNREG 435

  Fly   419 LQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLL 483
            ::||..:..:.|....:::...:|.|.::....||     |:.|:|     ....|:.:.  .|.
Mouse   436 IRQEYLKLEMLLKANALKSSYHQQCHKQIEMMCSE-----DKVEKA-----TCKRDHRLE--KLK 488

  Fly   484 VNRVHVELQRTQEELESQGHESRQRLSSRSHTEG---GESGG--DEVHEMLHSHSEEYTNKQMNF 543
            .|...  |::.:||:..|..|:...| .|...|.   |::|.  :.:::.||.|.....||::.
Mouse   489 TNSCF--LEKKKEEVSKQFDENTNWL-HRVENEMRLLGQNGDIPEALNKELHCHHLHLQNKELK- 549

  Fly   544 AGELRNINRQLDLKQELHER-----------IMRNFSRL----------DSDDEDVKLRLCNQKI 587
             .::.::.....|:::.|::           :.:.:.:|          |||.:|::..:..:|:
Mouse   550 -TQMAHMTALACLQEQQHKQTEAVLNALLPVLRKQYWKLKETGLSNAAFDSDFKDIEHLVERKKV 613

  Fly   588 ------DDLEAERRDL--------MDQLRNIKSKDISA----------KLAEERRKRLQLLEQEI 628
                  .:..:.|.||        ..||..|:|  ||.          ||..:||
Mouse   614 VAWADQTNEHSNRNDLPGISLLMTFPQLEPIQS--ISCCTSVSDPNVLKLTPQRR---------- 666

  Fly   629 SDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQ 693
              .|||:|...  ||::..::..:.. ||::......:::.|.....:.:|.:.    ....||:
Mouse   667 --TRRKIIPSP--LKVQHTQKSALSE-STQLNDSFSKELQPIVYTPEDCKKAQD----LFPSLTR 722

  Fly   694 LKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDAL----------ERQASAQAQRH 748
            ..|:...:.:: ..|:.|...:..:.:.:|::.|.:...|.|::          |..||:::..|
Mouse   723 TSSQSANVMND-NSQKALCRIESPLSRTECKQGLYSTSTLCDSIRGLKNKWPEQEPLASSKSSVH 786

  Fly   749 KY-------KDNGGSAAG--------------------SSNANAKTD 768
            :.       ||:...:||                    :|||:.|:|
Mouse   787 RIESSSFSTKDSMPESAGVPSYMAMTTAAKRKWKQMSSTSNASIKSD 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	123/299 (41%)
		Smc	<453..>985	CDD:440809	75/403 (19%)
		Metallothio	<1071..1115	CDD:395080
Kif18a	NP_001405889.1	KISc_KIP3_like	11..355	CDD:276821	123/298 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	774..804		6/29 (21%)