Protein Alignment Klp3A and Kif20a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_033030.1
• Gene: Kif20a / 19348
• MGIID: 1201682
• Length: 887
• Species: Mus musculus
• Alignment Length: 766
• Identity: 184/766 - (24%)
• Similarity: 298/766 - (38%)
• Gaps: 204/766 - (26%)

  Fly     4 EDPS-CVAVALRVRPLVQSELDR----GC----------------RIAVERSADGAPQVTVNRNE 47
            ||.| .|.|.||:||.:.|||||    ||                ..|::.:..|..|.|    .
Mouse    58 EDTSEKVKVYLRIRPFLTSELDRQEDQGCVCIENTETLVLQAPKDSFALKSNERGVGQAT----H 118

  Fly    48 SYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTA---------- 101
            .:|::.:|..:..|...|...::..||.:|.|.|..|..||.|.||||||: ||:
Mouse   119 KFTFSQIFGPEVGQVAFFNLTMKEMVKDVLKGQNWLIYTYGVTNSGKTYTIQGTSKDAGILPQSL 183

  Fly   102 ---FN-----------------------------------------GVLDDHVGV-IPRAVH--- 118
               ||                                         |:.::.:.. :.:.||
Mouse   184 ALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLIGGLQEEELSTSVKKRVHTES 248

  Fly   119 ------------------DIFTAIAEMQ-----------------SEFRFAVTCSFVELYQEQFY 148
                              ..||:.:::.                 ::.||:|..||.|:|.|..|
Mouse   249 RIGASNSFDSGVAGLSSTSQFTSSSQLDETSQLWAQPDTVPVSVPADIRFSVWISFFEIYNELLY 313

  Fly   149 DLFS--SKTRDKATVDIREVKN-RIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSR 210
            ||..  |....:.|:.:.|.:| ...:..|..:.|...::....|..|...::.|:|.||:.|||
Mouse   314 DLLEPPSHQHKRQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGRKNQSFASTHMNQQSSR 378

  Fly   211 SHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINA 275
            ||:||::.::..:.:|......|..:|.|||||||| |...||:|.||..|||..|..||..|.|
Mouse   379 SHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERC-KHQKSGERLKEAGNINTSLHTLGRCIAA 442

  Fly   276 LGSGQ----AAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIK 336
            |...|    ....||:|.|||||:.|....|...:.||..|:|......|||...:::..|.|:.
Mouse   443 LRQNQQNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHAAKFSALASQLV 507

  Fly   337 NKPVVNLDPHAAEVNMLKDVIQKLRVELLSG----GKMSSSLISAVGAAGLGAIPCEESLAGSMA 397
            :.|.|:|.     :..|...|:|...::..|    .|..|.|..:.          |:....|:.
Mouse   508 HAPPVHLG-----IPSLHSFIKKHSPQVGPGLEKEDKADSDLEDSP----------EDEADVSVY 557

  Fly   398 NAAEIQRLKEQVRT--LQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQ 460
            ...|:.::.|.::.  |::|..|||.|:          ::|..|.           :|:..::.|
Mouse   558 GKEELLQVVEAMKALLLKERQEKLQLEI----------QLREEIC-----------NEMVEQMQQ 601

  Fly   461 REQAQFGNENTNGDNEMRDFSLLVNRVHVE-LQRTQEELESQGHESRQRLSSRSHTEGGESGGDE 524
            ||  |:.:|..:...|      |:..::.| |:..:|.|.:...|..|....:.         :|
Mouse   602 RE--QWCSERLDNQKE------LMEELYEEKLKILKESLTTFYQEQIQERDEKI---------EE 649

  Fly   525 VHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDD 589
            :..:|....::...:|   :|.|..:.|.        :|:..:.|.....:...:|..|..::..
Mouse   650 LETLLQEAKQQPAAQQ---SGGLSLLRRS--------QRLAASASTQQFQEVKAELEQCKTELSS 703

  Fly   590 LEAERRDLMDQLR-----NIKSKDISAKLAEERRKRLQLLEQEISDLRRKL 635
            ..||.......|:     ...:.|:..|| ||.:|.::||..|:..|.:.|
Mouse   704 TTAELHKYQQVLKPPPPAKPFTIDVDKKL-EEGQKNIRLLRTELQKLGQSL 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	122/450 (27%)
		Smc	<453..>985	CDD:440809	38/189 (20%)
		Metallothio	<1071..1115	CDD:395080
Kif20a	NP_033030.1	KISc_KIF23_like	62..504	CDD:276819	119/446 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	527..553		5/35 (14%)
		SMC_prok_B	<560..>793	CDD:274008	48/244 (20%)
		RBD_KIF20A	601..656	CDD:409645	15/71 (21%)
		Globular. /evidence=ECO:0000255	805..887
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	826..875