Protein Alignment Klp3A and klp-4

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001359864.1
• Gene: klp-4 / 180608
• WormBaseID: WBGene00002217
• Length: 1576
• Species: Caenorhabditis elegans
• Alignment Length: 1302
• Identity: 313/1302 - (24%)
• Similarity: 508/1302 - (39%)
• Gaps: 344/1302 - (26%)

  Fly     4 EDPSCVAVALRVRPLVQSELD----RGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDD----- 59
            ::.|.|.||:||||..:.|||    ...||..|:.....| :....::::|:::.|...|
 Worm     5 DEESAVKVAIRVRPFNKRELDLKTKSVVRIQKEQCVLHHP-IEEKNSKTFTFDHSFCSTDPHSYD 68

  Fly    60 --SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDIF 121
              ||:.:........|:...:|||..|.|||||||||:|| |||      .|..|:|||..:|||
 Worm    69 FASQETVSYHLGSGVVENAFSGYNACIFAYGQTGSGKSYTMMGT------PDQPGIIPRVCNDIF 127

  Fly   122 TAIAE-MQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTELVVTS 182
            |.|.| ..|...|.|..|::|:|.|:..||...|...|| :.:||  ::|:.|   ||:.|.|.|
 Worm   128 TRIQETSNSSLSFKVEVSYMEIYNERVRDLLDPKKSSKA-LKVRE--HKILGPMVDGLSILAVNS 189

  Fly   183 AQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLD---GKQSVTTSRFNLVDLAGSE 244
            .:|:::.|..|:..|.||||.||..||||||:|:|.:..|..|   |......::.:||||||||
 Worm   190 FEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLIVTQTLHDLENGFSGEKVAKISLVDLAGSE 254

  Fly   245 RCSKTLASGDRFKEGVNINKGLLALGNVINALG--SGQAAGYIPYRQSKLTRLLQDSLGGNSITL 307
            |..||.|.|.|.:||.||||.|..||.||:||.  :.:...:||||.|.||.||:|||||||.|:
 Worm   255 RAGKTGAVGKRLEEGGNINKSLTTLGMVISALAERNSKKDKFIPYRDSVLTWLLKDSLGGNSRTV 319

  Fly   308 MIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSS 372
            |||.:|||..|..||||||||||||.:|.|..::|.||:|..:..|::.::.||:::....|
 Worm   320 MIATLSPAADNYEETLSTLRYADRAKKIVNHAIINEDPNARVIRELREEVETLRMQITQTKK--- 381

  Fly   373 SLISAVGAAGLGAIPCEESLAGSMANAAEI-QRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMR 436
                                  ..|...|: :||.|..|.:...|:..::.|.::  |...||.:
 Worm   382 ----------------------EHAETEELRERLAESERLVAQMNKSWEERLKET--DTLNKERQ 422

  Fly   437 AHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVH-VELQRTQEELES 500
            ..:.|..   :....|.:|.:.|     :|...|.|.|..:.:  |||..:: ..:....||||:
 Worm   423 KDLTEIG---ISIESSGIKVEKD-----RFYLVNMNADPSLNE--LLVYYINGSAIIGNSEELET 477

  Fly   501 QGHESRQRLSSRSHTEGGESGGDEVHE----------MLHSHS----EEY--------------- 536
                  .|.|..|.|....|..|:..|          ::..|:    |||
 Worm   478 ------SRDSGLSMTCSDSSRRDDDKERTSIVLRGLGIMRRHAKMTVEEYGGRLRLFVAPMSSEC 536

  Fly   537 ----TNKQMNFAGELRNINRQL---------------DLKQELHERIMRNFSRLDSDD------- 575
                ..||:.....|||.||.|               |::|.    ||.:.:..|.:|
 Worm   537 RICVNGKQITERTLLRNGNRLLVGMNHFFKVNCPKVMDMEQS----IMEDSTMFDYNDAWHEVND 597

  Fly   576 ------------EDVKLRLCNQKIDDLEAERRDLMDQLRNIKS---------------------- 606
                        |.|.|:....|...||.:.......::::.:
 Worm   598 ANPISSAVDQYMESVTLKHQEDKKAALEQQYEAFEKYIQSLTAGGFTPSTPMTPGFCLPTPITTP 662

  Fly   607 -------------KDISAKLAEERRKRLQLLEQEISDLR------RKLITQANLLKIRDKEREKI 652
                         :.:.:|.....:::.::..:.:..|:      ..|:.:||::.....::.|.
 Worm   663 TGLPPFPFPANPKQSVKSKFFYWAQRKEEMFAESLKRLKADVIHANALVREANMISKELNKKPKR 727

  Fly   653 Q-----NLSTEIRTMKESKVKL-------IRAMRGESEKFRQ-WKMVR-EKELTQLKSKDRKMQS 703
            |     .|......::..|:|.       :..:|.|.....| |.:.: |..|..::.....|.:
 Worm   728 QTTYDVTLQIPASNLRPIKIKAGQFVCEPVIVVRREGMSGSQFWTVSQLESRLVDMRDTYNDMLN 792

  Fly   704 EIVRQQ-----TLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNA 763
            ...|..     |.|:...::......|.        .:|......::|.|.      :..|.:|.
 Worm   793 GFTRTSESLNGTPHASPMKIAGIPMNEC--------SSLVIDPFFESQEHH------NLVGVANV 843

  Fly   764 NAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINN-H---YHLLQQEKTSDPAEAAEQARILA 824
                      .||::...:..::.:..:.:...|... |   :.::.||:..:.:....:..:..
 Worm   844 ----------FLEVLFHDLRLDYQVPIISQQGEVAGRLHVQIFRVVTQEEMDETSNNGPETLLGK 898

  Fly   825 SLEEELEMRNA------------------QISDL----------QQKVCPT-------------- 847
            ::...:.::.|                  .||:|          ....|||
 Worm   899 TITCRVRIKRASGLPEKLSNFVFCQYSFFNISELLVVAPANEAANHSSCPTTVIFEHQRDFNVMV 963

  Fly   848 --DLDSRIRSLAEGVQSLG-------ESRTV-----SKQLLKTLVQ-QRRLQASSLNEQRTTLDE 897
              :....:|..|..::..|       |.|.:     ||.|....:: .|||:..|  |.|...|.
 Worm   964 TEEFMEYVRDDALSIEVWGHRICGHPEERILDTDEKSKSLQNRWMEVTRRLETWS--EVRELNDN 1026

  Fly   898 LRAQLLDAQQQEDAASKRL-RLLQSQHEEQMLAQQRAYEEKVSVLI---------------RTAN 946
            .....::.:..:|.::..: :|.|.|....::....|..:.:.:.|               .|.|
 Worm  1027 GDWTSVEVRHADDVSTGGIYQLKQGQQRRLVVGVNVAAPDGLPISIDCITSVSIGAIMAVKSTNN 1091

  Fly   947 QRWAEARSPAE-DQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGN 1010
            .:..::....: |:.|.|....|.|.:..||.:||.|.||: .||:|      :||....::.
 Worm  1092 LKSIDSYQEEDLDKIRKQWSHALKSRQYYLQHQLDSLSAKS-GKSEA------ELDREHSLMG-- 1147

  Fly  1011 ETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISP--------PEKQDANVTSLGNSSIQSLNSTS 1067
                        .||..|.:...::..:.|...|        ||..:.::..|    ...|||..
 Worm  1148 ------------QWVALTEERTAVECPTPNSCIPGAPCDWIAPEGVERHIPVL----FLDLNSDD 1196

  Fly  1068 AT 1069
            .|
 Worm  1197 MT 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	155/349 (44%)
		Smc	<453..>985	CDD:440809	116/737 (16%)
		Metallothio	<1071..1115	CDD:395080
klp-4	NP_001359864.1	KISc_KIF1A_KIF1B	10..354	CDD:276816	156/353 (44%)
		Kinesin_assoc	351..463	CDD:465047	30/148 (20%)
		FHA_KIF13	443..570	CDD:438758	30/134 (22%)
		KIF1B	776..840	CDD:463574	10/77 (13%)
		DUF3694	<1239..1293	CDD:463599