DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and klp-12

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001023349.1	Gene:	klp-12 / 178057	WormBaseID:	WBGene00002223	Length:	1605	Species:	Caenorhabditis elegans

Alignment Length:	1305	Identity:	371/1305 - (28%)
Similarity:	582/1305 - (44%)	Gaps:	286/1305 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQA 71
            :||.||||:||....|...|.|:... .....||||:..:.|:||::|||:...|..::|:||:.
Worm     4 TCVQVALRIRPQGNREKLEGSRVCTS-VLPNDPQVTIGGDRSFTYDHVFDMPTLQYVVYESCVEK 67

  Fly    72 KVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVL---DDHVGVIPRAVHDIFTAIAEMQS---- 129
            .|..|.:|||.|:|||||||||||:||||||:..:   ::.:||||||:...|..|||.::
Worm    68 LVDGLFDGYNATVLAYGQTGSGKTHTMGTAFDAAVTQKEEDLGVIPRAIQHTFRKIAECKAQAIE 132

  Fly   130 ----EFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDH 189
                |..|.|:..|||||.:...||.|......:::.|.| .:..|::.|:.:..|.......|.
Worm   133 QGLLEPAFEVSVQFVELYNDDVLDLLSDDRSMSSSIRIHEDSRGEIVLHGVEQRSVFDMHGTMDI 197

  Fly   190 LIRGSAGRAVAATAMNETSSRSHAIFTLTL-----VATKLD--GKQ-------SVTTSRFNLVDL 240
            |..|:..|.||||.|||.||||||||||.|     .|..||  |:|       .:..::|:.|||
Worm   198 LKNGALNRTVAATNMNEQSSRSHAIFTLHLKQQRVAANPLDESGEQKTGELEMEMLCAKFHFVDL 262

  Fly   241 AGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQA-AGYIPYRQSKLTRLLQDSLGGNS 304
            |||||..:|.|:|||.|||::||.|||||||||.|||.... ..::|||.|||||||||||||||
Worm   263 AGSERMKRTGATGDRAKEGISINVGLLALGNVIAALGGANGKVSHVPYRDSKLTRLLQDSLGGNS 327

  Fly   305 ITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGK 369
            .||||||.||:|.:..|||:|::||:||.:||||.|.|.|..:..:..|:..|..|..|||. .|
Worm   328 RTLMIACCSPSDSDFVETLNTMKYANRAKEIKNKVVANQDKSSKMIGELRSRIAALEAELLE-FK 391

  Fly   370 MSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDR---------NRKLQQELH- 424
            .....:...|...:     .:....::...:|:..|:.:|:.|.:.         :.|.:||.:
Worm   392 QGRRTVDVDGHEVV-----NDQYHENVYLTSEVNHLRFRVKALNETLDILRTENIDLKAKQEFNS 451

  Fly   425 ------------QSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQ------REQAQFGNENT 471
                        :..:|..:...|.::.|.  ::.:|.:.|.::..||      |.:|...:..:
Worm   452 IASLPTAGSGGAEGEVDAIQSTFRKYLEEL--ERTKSLLYESQSTCDQLRKDNARWKALGASRGS 514

  Fly   472 NGDNEMRDFSLLVNRVHVELQRTQEELES---QGHESRQRLSSRSHTEGGESGGDEVHEML---- 529
            .|.|...:...|:.....|:::.::.:||   .|.......||.:..|.|.|  :|..|:|
Worm   515 GGGNAEFNSQKLIEMAKQEVEKQRKLMESVNIGGENVSSEYSSMAQDEDGTS--NEAEELLDEED 577

  Fly   530 --HSHSEEYTNKQMNFAGE-----LRNINRQLDLKQELHERIMRNFSRLDSDDEDV------KLR 581
              ....|....||.....|     |..:..:||:|::|.:::    .|.:..::.:      |||
Worm   578 LDEDEDETAEEKQEQEESEALQIDLSEVMIELDIKEKLIDQL----ERAERQNQQIRETYEKKLR 638

  Fly   582 LCNQKIDDLEAERRDLM----------DQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKL- 635
            ...::|.|.|.||..::          :|::.||                |..|.:|:|||::|
Worm   639 ELMERIKDTETERDRVLNEGGKRGGNNEQMKAIK----------------QEYELKITDLRKELK 687

  Fly   636 ---ITQANLLKIRDKEREKIQ---NLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQL 694
               ......||:..|.:.::|   .|.:|:..:|::||:||:.|..:.:|.:..::...:... .
Worm   688 KIEALDKEHLKVIAKSQRELQEKTRLKSEVVDLKKAKVELIKKMNEDKKKQKTQQLANARAFA-T 751

  Fly   695 KSKDRKMQSEIVRQQTLHSKQR-QVLKRKCEE--ALAANKRLKDALERQASAQAQRHKYKDNGGS 756
            |.|..::|:..:|...:..||| |.||:..:|  ||...|.:..|..|||:....|      ||:
Worm   752 KEKQTRLQANKIRTLEMKDKQREQFLKKTTQEVNALRKEKAVAAATARQANRGTPR------GGA 810

  Fly   757 AAGSS--------------------NANAKTDSW--VDRELE------IILSLIDAEHSLEQLME 793
            |..:|                    :|.|....|  :.|::|      .|:..::||  ||:.:.
Worm   811 AVTNSPARRVRGVVGGVQAIKELAFSAKASKVKWDVIVRKIEESARRRQIVQKMEAE--LERYLN 873

  Fly   794 DR-----AVINNHYHLLQQEKT---SDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLD 850
            :|     .::.|.....|.:..   ....||.:.|:      ::|:....||:..|:.:|..|.|
Worm   874 ERHAVMVEIVENEKQFTQSQDVIYRDGLLEAIDSAK------QKLQYVQDQITYQQKLICDVDED 932

  Fly   851 ------------------SRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDE 897
                              ..|:.|.:|..:|.|:|.:.:.|....:.:..|.|...:|    ..|
Worm   933 ITASNAENEPILDVGLKKQTIKQLFDGCDTLSEARYLLQHLFDLCIDKAALAAKVESE----FKE 993

  Fly   898 LRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQ----------RAYEEKVSVLIRTANQRWAEA 952
            ..|::   :|.|..:|.:.:||.|..|::.|..:          ::.....|.|:|:.
Worm   994 CAARI---EQLEQQSSLKEQLLTSIIEDKNLVDEIEGFVPSDLRKSRTSSQSSLLRSG------- 1048

  Fly   953 RSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETV-VLS 1016
             ||:..:..:.:....:....|.|:||  |.|.::..|.        :.|:    :.|.|| |.:
Worm  1049 -SPSVVEDAHTLQNYKVRRHTATQEEL--LFANSEENSM--------VSDA----NANPTVDVGA 1098

  Fly  1017 DVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNS----------------------S 1059
            ||.|..:   ...|.|||...|   .||.....||.||...|                      |
Worm  1099 DVGDSDE---RKEKKKRIAFVS---TSPASTSFANSTSQSPSFSRNTRFRSTVGGVSNNNNIRKS 1157

  Fly  1060 IQSL------NST---------SATED---GKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKS 1106
            :|.|      :||         |.|||   |...|....|:     |...:|.:::.:.|.:..|
Worm  1158 VQPLINGKGVSSTARKGISRLPSVTEDPEIGIFAKSFPGRS-----RSNLMSSSSSTTTTTLSSS 1217

  Fly  1107 NCRNP 1111
            |..||
Worm  1218 NLLNP 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	167/355 (47%)
		Kinesin	14..335	CDD:278646	162/347 (47%)
		Smc	<396..>994	CDD:224117	150/729 (21%)
		FlaC	522..633	CDD:225888	29/137 (21%)
		TCR	1075..1110	CDD:281618	7/34 (21%)
klp-12	NP_001023349.1	KISc_KIF4	4..359	CDD:276823	167/355 (47%)
		KISc	6..365	CDD:214526	171/359 (48%)
		ATP-synt_B	<609..739	CDD:304375	36/149 (24%)
		WD40	1277..1601	CDD:238121
		WD40	<1287..1603	CDD:225201
		WD40 repeat	1288..1322	CDD:293791
		WD40 repeat	1327..1364	CDD:293791
		WD40 repeat	1373..1429	CDD:293791
		WD40 repeat	1439..1482	CDD:293791
		WD40 repeat	1489..1524	CDD:293791
		WD40 repeat	1531..1556	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820