Protein Alignment Klp3A and Kif5b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 1096
• Identity: 290/1096 - (26%)
• Similarity: 479/1096 - (43%)
• Gaps: 294/1096 - (26%)

  Fly     5 DPS-C-VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFET 67
            ||: | :.|..|.|||.:||::||.:...:...:....:.   ::.|.::.||....||:.::..
Mouse     3 DPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIA---SKPYAFDRVFQSSTSQEQVYND 64

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD--HVGVIPRAVHDIFTAIAEMQSE 130
            |.:..||.:|.|||.||.|||||.||||:||    .|.|.|  .:|:|||.|.|||..|..|...
Mouse    65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTM----EGKLHDPEGMGIIPRIVQDIFNYIYSMDEN 125

  Fly   131 FRFAVTCSFVELYQEQFYDLFS-SKTRDKATVDIREVKNRI-IMPGLTELVVTSAQQVTDHLIRG 193
            ..|.:..|:.|:|.::..||.. |||    .:.:.|.|||: .:.|.||..|.|..:|.|.:..|
Mouse   126 LEFHIKVSYFEIYLDKIRDLLDVSKT----NLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEG 186

  Fly   194 SAGRAVAATAMNETSSRSHAIFTL------TLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLAS 252
            .:.|.||.|.|||.|||||:||.:      |....||.||       ..||||||||:.|||.|.
Mouse   187 KSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGK-------LYLVDLAGSEKVSKTGAE 244

  Fly   253 GDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADY 317
            |....|..||||.|.||||||:||..|..  |:|||.||:||:||||||||..|.::.|.||:.|
Mouse   245 GAVLDEAKNINKSLSALGNVISALAEGST--YVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSY 307

  Fly   318 NVAETLSTLRYADRALQIKNKPVVNLDPHA----------AEVN-MLKDVIQ------------- 358
            |.:||.|||.:..||..|||...||::..|          .|.| .|::.||
Mouse   308 NESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGE 372

  Fly   359 -----------KLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQV--- 409
                       |..:|..:..| ..::.|...||.:|       :|||..: ||.::.:|::
Mouse   373 TVPIDEQFDKEKANLEAFTADK-DIAITSDKPAAAVG-------MAGSFTD-AERRKCEEELAKL 428

  Fly   410 -RTLQDRNRKLQQE------LHQSLLDLTE---------KEMRAHI--AEQAHDKLRSHVSELKN 456
             :.|.|::.::.|:      |...:||..|         ..|:|.:  .:..:|..:..|.|:..
Mouse   429 YKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQ 493

  Fly   457 KLDQREQAQFGNENTNGDNEMRDFSLLVNR----------VHVELQRTQEELESQGHESRQRLSS 511
            .|::. ...:..::...:::.:::.||.:.          :..|||:.:|....|...:.:.::|
Mouse   494 ALEEL-AVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMAS 557

  Fly   512 --RSHTEGGES-GGDEVHE-----MLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNF 568
              :...|.|.: |.::|.:     |:   .||:|..::..:          .:|.|: :.:::..
Mouse   558 LLKDLAEIGIAVGNNDVKQPEGTGMI---DEEFTVARLYIS----------KMKSEV-KTMVKRC 608

  Fly   569 SRLDS---------DDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLL 624
            .:|:|         ::.:.:|..|..:|...||:.:.|.:.|:|:           |::||  .|
Mouse   609 KQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNV-----------EQKKR--QL 660

  Fly   625 EQEISDLRRKLITQANLLKIRDKEREKIQNLST----------EIRTMKESKVKLIRAMRGESEK 679
            |:.:..|..:|:......|:.:.|:|.:..:.|          :|::.:|:..|.|.::|.|.|
Mouse   661 EESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVE- 724

  Fly   680 FRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQ 744
                  .:||.:|.|:.:::||..|..|.:..|                  :|||
Mouse   725 ------AKEKLITDLQDQNQKMVLEQERLRVEH------------------ERLK---------- 755

  Fly   745 AQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEK 809
                                 .||....|:|          |.| .:|:||
Mouse   756 ---------------------ATDQEKSRKL----------HEL-TVMQDR-------------- 774

  Fly   810 TSDPAEAAEQAR-ILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQL 873
                   .|||| .|..|||.:......:.:| :|:...||.:|::..|| |.|.....:.:::.
Mouse   775 -------REQARQDLKGLEETVAKELQTLHNL-RKLFVQDLATRVKKSAE-VDSDDTGGSAAQKQ 830

  Fly   874 LKTLVQQRRLQASSLNEQ--RTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEE 936
            ..:.::....|.:.:::|  |...| ||.:|...:::..|.::|::.|:|..:|   |::.|..:
Mouse   831 KISFLENNLEQLTKVHKQLVRDNAD-LRCELPKLEKRLRATAERVKALESALKE---AKENASRD 891

  Fly   937 KVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKA 992
                                               |:..|||:|:::...:||:.|
Mouse   892 -----------------------------------RKRYQQEVDRIKEAVRSKNMA 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	145/340 (43%)
		Smc	<453..>985	CDD:440809	105/571 (18%)
		Metallothio	<1071..1115	CDD:395080
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	145/338 (43%)
		SMC_prok_B	<417..803	CDD:274008	92/502 (18%)
		Khc_CBD_cc	834..903	CDD:467880	19/107 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963		3/5 (60%)
		Globular	915..963