Protein Alignment Klp3A and Kif4

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_032472.2
• Gene: Kif4 / 16571
• MGIID: 108389
• Length: 1231
• Species: Mus musculus
• Alignment Length: 1266
• Identity: 425/1266 - (33%)
• Similarity: 651/1266 - (51%)
• Gaps: 211/1266 - (16%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            |.||||.||||..|:..||:..:. ...|.|||.|..::|:||::|||....|:::|.|.|...:
Mouse    10 VRVALRCRPLVSKEIKEGCQTCLS-FVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLI 73

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVL--DDHVGVIPRAVHDIFTAIAEMQSEFRFAVT 136
            |.:..|||.|:||||||||||||:||.|:....  |..:|||||.:..:|..| ..:|:|.|.:.
Mouse    74 KGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEI-NKKSDFEFTLK 137

  Fly   137 CSFVELYQEQFYDLFSSKTRDKAT-VDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAV 199
            .|::|:|.|:..||..| :|:||| ::||| .|..|.:.||||..|..|......|.:|:..|.|
Mouse   138 VSYLEIYNEEILDLLCS-SREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTV 201

  Fly   200 AATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINK 264
            |:||||..|||||||||:::...|.:.|.|...|:.:|||||||||..||.|.|||.:||:|||:
Mouse   202 ASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININR 266

  Fly   265 GLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYA 329
            |||.|||||:|||..:...::|||.|||||||||||||||.|||||||||||.|:.|||:|||||
Mouse   267 GLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYA 331

  Fly   330 DRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS--GGKMSSSLISAVGAAGLGAIPCEESL 392
            |||.:|||||::|:||.|||:|.||..:|:|::.||.  ||.:.            |.|..|.|
Mouse   332 DRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLP------------GDINVEPS- 383

  Fly   393 AGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKN- 456
                   ..:|.|.|:.::|.:.|.||.:.|.::.....:...|..:.|||::|:.:.:.||:.
Mouse   384 -------ENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRH 441

  Fly   457 ---KLDQREQAQFGNENTNGDNEMRD-FSLLVNRVHVELQRTQE-------ELESQGHESRQRLS 510
               |:|.::..:     |..|.|::: ..::.|...|..|.:.|       .:::.|....|..|
Mouse   442 AACKVDLQKLVE-----TLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQS 501

  Fly   511 SRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDD 575
            |...:...:           ..|.::..:|...:.||..:|:.|.||:.|.:::.:|.::|....
Mouse   502 SPDTSRSSD-----------VFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQ 555

  Fly   576 EDVKLRLCN--QKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQ 638
            ...:..:.|  .::..|:.|:.:|:.:|:..|.....|||:|.||||||.||.:|:||::||..|
Mouse   556 FQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQ 620

  Fly   639 ANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQS 703
            :.|||:::.....:..|:.|||.||..:|:|:|.|:.::|||||||..::||:.|||.:|||.|.
Mouse   621 SKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQY 685

  Fly   704 EIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTD 768
            |:::.:....||..||:||.|||.||||||||||::|.....:|.:.:     :.|..:..|:..
Mouse   686 ELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQ-----SRGMESTAARMK 745

  Fly   769 SWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTS---------------------D 812
            :|:..|:|:::|..:|:..|..|:|:|.::......|::::.|                     |
Mouse   746 NWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQD 810

  Fly   813 PAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTL 877
            .......|:.:.|||.|||:|:|||:|||||:...:.:.|.:...|.:.::.|::...|.|:..|
Mouse   811 SGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGEL 875

  Fly   878 VQQRRLQA---SSLNEQRTT-LD-----------------ELRAQLLDAQQQEDAASKRLRLLQS 921
            |..:.|.:   ||||:.:.: :|                 ||:.:|:..:||..  .|.|.||..
Mouse   876 VSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQ--EKVLYLLSQ 938

  Fly   922 QHEEQMLAQQ--RAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRA 984
            ..:.||..:|  .:..||...|:.|...:..|.|...|..::||   :||....|::|:|..|:.
Mouse   939 LQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQ---QLLQENSAIKQKLTLLQV 1000

  Fly   985 KNKSKSKAVKSEPQDLDDSFQ--------------------IVDG-------------NETVVLS 1016
            .:|.|....::..|..|.||:                    .|:|             ||.   |
Mouse  1001 ASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNED---S 1062

  Fly  1017 DVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCR 1081
            |...|.:|:|:                       .:..:...|||               ||.|:
Mouse  1063 DDHADEEWIPT-----------------------KLVKVSKKSIQ---------------GCSCK 1089

  Fly  1082 TKCTTKRCGCLSGNNACSETCVC-KSNCRNPLNLKDHASQCGDGDGQKDETEDADKSDDDGDD-- 1143
            ..|..|:|||....:.|:.:|.| .:.|||     .|         |..:..||.:.:.|.::
Mouse  1090 GWCGNKQCGCRKQKSDCNVSCSCDPTKCRN-----RH---------QNQDNSDAIELNQDSENSF 1140

  Fly  1144 --EPQTSKENAVKFVTPEAPGKVVASPKQTL 1172
              |..|...:.:.|..|     :.|:|...:
Mouse  1141 KLEDPTEVTSGLSFFHP-----ICATPSSKI 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	174/330 (53%)
		Smc	<453..>985	CDD:440809	171/589 (29%)
		Metallothio	<1071..1115	CDD:395080	14/44 (32%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	174/330 (53%)
		Smc	<518..>1005	CDD:440809	156/496 (31%)
		Globular	1001..1231		43/226 (19%)
		Pre-SET	<1082..1120	CDD:461530	17/57 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1212