DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp3A and Kif4

DIOPT Version :9

Sequence 1:NP_001284830.1 Gene:Klp3A / 31240 FlyBaseID:FBgn0011606 Length:1212 Species:Drosophila melanogaster
Sequence 2:NP_032472.2 Gene:Kif4 / 16571 MGIID:108389 Length:1231 Species:Mus musculus


Alignment Length:1266 Identity:425/1266 - (33%)
Similarity:651/1266 - (51%) Gaps:211/1266 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            |.||||.||||..|:..||:..:. ...|.|||.|..::|:||::|||....|:::|.|.|...:
Mouse    10 VRVALRCRPLVSKEIKEGCQTCLS-FVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLI 73

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVL--DDHVGVIPRAVHDIFTAIAEMQSEFRFAVT 136
            |.:..|||.|:||||||||||||:||.|:....  |..:|||||.:..:|..| ..:|:|.|.:.
Mouse    74 KGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEI-NKKSDFEFTLK 137

  Fly   137 CSFVELYQEQFYDLFSSKTRDKAT-VDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAV 199
            .|::|:|.|:..||..| :|:||| ::||| .|..|.:.||||..|..|......|.:|:..|.|
Mouse   138 VSYLEIYNEEILDLLCS-SREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTV 201

  Fly   200 AATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINK 264
            |:||||..|||||||||:::...|.:.|.|...|:.:|||||||||..||.|.|||.:||:|||:
Mouse   202 ASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININR 266

  Fly   265 GLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYA 329
            |||.|||||:|||..:...::|||.|||||||||||||||.|||||||||||.|:.|||:|||||
Mouse   267 GLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYA 331

  Fly   330 DRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS--GGKMSSSLISAVGAAGLGAIPCEESL 392
            |||.:|||||::|:||.|||:|.||..:|:|::.||.  ||.:.            |.|..|.| 
Mouse   332 DRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLP------------GDINVEPS- 383

  Fly   393 AGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKN- 456
                   ..:|.|.|:.::|.:.|.||.:.|.::.....:...|..:.|||::|:.:.:.||:. 
Mouse   384 -------ENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRH 441

  Fly   457 ---KLDQREQAQFGNENTNGDNEMRD-FSLLVNRVHVELQRTQE-------ELESQGHESRQRLS 510
               |:|.::..:     |..|.|::: ..::.|...|..|.:.|       .:::.|....|..|
Mouse   442 AACKVDLQKLVE-----TLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQS 501

  Fly   511 SRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDD 575
            |...:...:           ..|.::..:|...:.||..:|:.|.||:.|.:::.:|.::|....
Mouse   502 SPDTSRSSD-----------VFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQ 555

  Fly   576 EDVKLRLCN--QKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQ 638
            ...:..:.|  .::..|:.|:.:|:.:|:..|.....|||:|.||||||.||.:|:||::||..|
Mouse   556 FQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQ 620

  Fly   639 ANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQS 703
            :.|||:::.....:..|:.|||.||..:|:|:|.|:.::|||||||..::||:.|||.:|||.|.
Mouse   621 SKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQY 685

  Fly   704 EIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTD 768
            |:::.:....||..||:||.|||.||||||||||::|.....:|.:.:     :.|..:..|:..
Mouse   686 ELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQ-----SRGMESTAARMK 745

  Fly   769 SWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTS---------------------D 812
            :|:..|:|:::|..:|:..|..|:|:|.::......|::::.|                     |
Mouse   746 NWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQD 810

  Fly   813 PAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTL 877
            .......|:.:.|||.|||:|:|||:|||||:...:.:.|.:...|.:.::.|::...|.|:..|
Mouse   811 SGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGEL 875

  Fly   878 VQQRRLQA---SSLNEQRTT-LD-----------------ELRAQLLDAQQQEDAASKRLRLLQS 921
            |..:.|.:   ||||:.:.: :|                 ||:.:|:..:||..  .|.|.||..
Mouse   876 VSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQ--EKVLYLLSQ 938

  Fly   922 QHEEQMLAQQ--RAYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRA 984
            ..:.||..:|  .:..||...|:.|...:..|.|...|..::||   :||....|::|:|..|:.
Mouse   939 LQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQ---QLLQENSAIKQKLTLLQV 1000

  Fly   985 KNKSKSKAVKSEPQDLDDSFQ--------------------IVDG-------------NETVVLS 1016
            .:|.|....::..|..|.||:                    .|:|             ||.   |
Mouse  1001 ASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNED---S 1062

  Fly  1017 DVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCR 1081
            |...|.:|:|:                       .:..:...|||               ||.|:
Mouse  1063 DDHADEEWIPT-----------------------KLVKVSKKSIQ---------------GCSCK 1089

  Fly  1082 TKCTTKRCGCLSGNNACSETCVC-KSNCRNPLNLKDHASQCGDGDGQKDETEDADKSDDDGDD-- 1143
            ..|..|:|||....:.|:.:|.| .:.|||     .|         |..:..||.:.:.|.::  
Mouse  1090 GWCGNKQCGCRKQKSDCNVSCSCDPTKCRN-----RH---------QNQDNSDAIELNQDSENSF 1140

  Fly  1144 --EPQTSKENAVKFVTPEAPGKVVASPKQTL 1172
              |..|...:.:.|..|     :.|:|...:
Mouse  1141 KLEDPTEVTSGLSFFHP-----ICATPSSKI 1166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp3ANP_001284830.1 KISc_KIF4 7..336 CDD:276823 174/330 (53%)
Kinesin 14..335 CDD:278646 170/324 (52%)
Smc <396..>994 CDD:224117 186/655 (28%)
FlaC 522..633 CDD:225888 32/112 (29%)
TCR 1075..1110 CDD:281618 12/35 (34%)
Kif4NP_032472.2 KISc_KIF4 8..338 CDD:276823 174/330 (53%)
KISc 9..344 CDD:214526 179/336 (53%)
SbcC 407..995 CDD:223496 175/613 (29%)
Globular 1001..1231 43/226 (19%)
Pre-SET <1070..1120 CDD:282838 19/92 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1189..1212
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 309 1.000 Domainoid score I1331
eggNOG 1 0.900 - - E2759_KOG0244
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H69022
Inparanoid 1 1.050 609 1.000 Inparanoid score I922
Isobase 1 0.950 - 0 Normalized mean entropy S3090
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D369179at2759
OrthoFinder 1 1.000 - - FOG0003140
OrthoInspector 1 1.000 - - oto93392
orthoMCL 1 0.900 - - OOG6_100464
Panther 1 1.100 - - LDO PTHR47969
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3568
SonicParanoid 1 1.000 - - X2108
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.850

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