Protein Alignment Klp3A and Kif3b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_032470.3
• Gene: Kif3b / 16569
• MGIID: 107688
• Length: 747
• Species: Mus musculus
• Alignment Length: 817
• Identity: 248/817 - (30%)
• Similarity: 397/817 - (48%)
• Gaps: 145/817 - (17%)

  Fly     2 SSEDPSCVAVALRVRPLVQSE----LDRGCRIAVERSADGAPQVTVNR--------NESYTYNYV 54
            |||.   |.|.:|.||:...|    .|:...:.|:..     ||:|..        .:::|::.|
Mouse     6 SSES---VRVVVRCRPMNGKEKAASYDKVVDVDVKLG-----QVSVKNPKGTSHEMPKTFTFDAV 62

  Fly    55 FDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD--HVGVIPRAV 117
            :|.:..|.:|::...:..|..:|.|:|.||.||||||:||||||    .||..|  ..||||.:.
Mouse    63 YDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTM----EGVRGDPEKRGVIPNSF 123

  Fly   118 HDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR----IIMPGLTEL 178
            ..|||.|:..|:: ::.|..|::|:|||:..||. ||.:.|..    |:|.|    :.:..|:..
Mouse   124 DHIFTHISRSQNQ-QYLVRASYLEIYQEEIRDLL-SKDQTKRL----ELKERPDTGVYVKDLSSF 182

  Fly   179 VVTSAQQVTDHLIR-GSAGRAVAATAMNETSSRSHAIFTLTLVATK--LDGKQSVTTSRFNLVDL 240
            |..|.::: :|::. |:..|:|.||.|||.||||||||.:|:..::  |||:..:...:.|||||
Mouse   183 VTKSVKEI-EHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDL 246

  Fly   241 AGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSI 305
            |||||.:||.|.|:|.||...||..|.||||||:||..|::. :||||.||||||||||||||:.
Mouse   247 AGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKST-HIPYRDSKLTRLLQDSLGGNAK 310

  Fly   306 TLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVEL----LS 366
            |:|:|.|.||.|||.|||:|||||:||..|||||.||.||..|.:...::.|.:|:.:|    :.
Mouse   311 TVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIG 375

  Fly   367 GGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLT 431
            ..|.........|:.|.|....||...|           :|......|..|:.|::|
Mouse   376 RRKRREKRREGGGSGGGGEEEEEEGEEG-----------EEDGDDKDDYWREQQEKL-------- 421

  Fly   432 EKEMRAHIAEQ---AHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQR 493
            |.|.||.:.:.   |.:|:|. :.|.:.|::...:.:...|......:..:..|||...:: :..
Mouse   422 EIEKRAIVEDHSLVAEEKMRL-LKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNI-VDH 484

  Fly   494 TQEE---LESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLD 555
            |.|:   ||    :.||.::.:...|      .|:.:.:.|..||....:..:.    ::.:::|
Mouse   485 TNEQQKILE----QKRQEIAEQKRRE------REIQQQMESRDEETLELKETYT----SLQQEVD 535

  Fly   556 LKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKR 620
            :|.:                   ||:....|:..::||..||.                ||..|.
Mouse   536 IKTK-------------------KLKKLFSKLQAVKAEIHDLQ----------------EEHIKE 565

  Fly   621 LQLLEQEISDLRRKLITQANLLK--IRDKEREKIQNLS----------------TEIRTMKESKV 667
            .|.|||..::|.|:|..:..:::  |..:|:.||.|.|                .|.:.|.:..|
Mouse   566 RQELEQTQNELTRELKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRLENQQMMKRPV 630

  Fly   668 KLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKR 732
            ..:...|..|:..|...|:|.:  .:.::::..:....:..:|....:...:..|.:.||.|..:
Mouse   631 SAVGYKRPLSQHARMSMMIRPE--PRYRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQ 693

  Fly   733 LKDALERQASA----QAQRHKYKDNGGSAAGSSNANA 765
            .:|.::..||:    .:::.|.:...|..:|||::::
Mouse   694 DEDEIQVDASSFESTASRKPKARPKSGRKSGSSSSSS 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	150/349 (43%)
		Smc	<453..>985	CDD:440809	63/338 (19%)
		Metallothio	<1071..1115	CDD:395080
Kif3b	NP_032470.3	KISc_KIF3	8..340	CDD:276822	151/351 (43%)
		Smc	<355..>581	CDD:440809	57/295 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		8/48 (17%)
		Globular	580..747		28/153 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	698..747		7/33 (21%)