Protein Alignment Klp3A and Kif3a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Alignment Length: 775
• Identity: 245/775 - (31%)
• Similarity: 369/775 - (47%)
• Gaps: 113/775 - (14%)

  Fly     3 SEDP-SC--VAVALRVRPLVQSELDRGCRIAVERSAD---GAPQVTVNRNES-------YTYNYV 54
            ||.| ||  |.|.:|.|||.:.|.....|.||  |.|   |.  :||::.:|       :|::.|
Mouse     6 SEKPESCDNVKVVVRCRPLNEREKSMCYRQAV--SVDEMRGT--ITVHKTDSSNEPPKTFTFDTV 66

  Fly    55 FDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGV--LDDHVGVIPRAV 117
            |..:..|.|::....:..:..:|.|||.||.||||||:|||:||    .||  :....||||.:.
Mouse    67 FGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTM----EGVRAVPGLRGVIPNSF 127

  Fly   118 HDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR----IIMPGLTEL 178
            ..||..||:.:.:.||.|..|::|:|.|:..||.......:.     |||.|    :.:..|:..
Mouse   128 AHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRL-----EVKERPDVGVYIKDLSAY 187

  Fly   179 VVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK--LDGKQSVTTSRFNLVDLA 241
            ||.:|..:...:..|...|:|.||.|||.|||||||||:|:..::  :||...|...:.:|||||
Mouse   188 VVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLA 252

  Fly   242 GSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSIT 306
            ||||.:||.|:|.|.||...||..|..|||||:||..|::. ::|||.|||||||||||||||.|
Mouse   253 GSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKST-HVPYRNSKLTRLLQDSLGGNSKT 316

  Fly   307 LMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMS 371
            :|.|.:.|||||..||:||||||:||..||||..:|.||..|.:...:..|::|:.:|..|.::|
Mouse   317 MMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVS 381

  Fly   372 SSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMR 436
            .|.||  |:.       |:...|.:....|.::         .|..........|...:.||.:.
Mouse   382 GSDIS--GSE-------EDDEEGELGEDGEKKK---------KRRGSSSSSSSDSTCSVIEKPLD 428

  Fly   437 AHIAEQAHDKLRS--HVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELE 499
            ..:..||..|..|  .:.|::.|:|:..:|.    .|..|.|..:    .|:...||:|.:::|.
Mouse   429 EFLPHQAGKKKVSPDKMVEMQAKIDEERKAL----ETKLDMEEEE----RNKARAELERREKDLL 485

  Fly   500 SQGHESRQRLSSRSHTE-----GGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQE 559
            ....|.:..|...|..|     ||      |..:..:..:|...::.|...|.|. .|...|::|
Mouse   486 KAQQEHQSLLEKLSALEKKVIVGG------VDLLAKAEEQEKLLEESNMELEERR-RRAEQLRKE 543

  Fly   560 LHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNI-----KSKDISAKLAEERRK 619
            |.|   :...|||.:          :|...|:.|.:....:|:.:     .:|...|.|.:|.::
Mouse   544 LEE---KEQERLDIE----------EKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQR 595

  Fly   620 RLQLLEQEISDLRRKLITQANLLK--IRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQ 682
            .::.|.:.|..|.|:|..|..::.  |....:|.|:|.......:.|.::|.: |..|.:
Mouse   596 EIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCV-AYTGNN----- 654

  Fly   683 WKMVREKELTQLKSKD----------RKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKR 732
              |.::..:...|.:|          .....|.:||..:..::.:..|.|....:...||
Mouse   655 --MRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKMGRRKR 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	151/348 (43%)
		Smc	<453..>985	CDD:440809	63/302 (21%)
		Metallothio	<1071..1115	CDD:395080
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	149/345 (43%)
		Smc	<450..>614	CDD:440809	43/191 (23%)