DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and Kif21a

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	XP_017171930.1	Gene:	Kif21a / 16564	MGIID:	109188	Length:	1685	Species:	Mus musculus

Alignment Length:	1372	Identity:	357/1372 - (26%)
Similarity:	590/1372 - (43%)	Gaps:	320/1372 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKVKKLLN 78
            |:||.:..|...||.|... ...|.|||.:.:::::|::||||||..|:.::..|::..::....
Mouse    23 RIRPQLAKEKIEGCHICTS-VTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYTQCIEKLIEGCFE 86

  Fly    79 GYNVTILAYGQTGSGKTYTMGTAFN-GVLDDHVGVIPRAVHDIFTAIAEMQSEF--------RFA 134
            |||.|:.||||||:||||||||.|: .::::..|:|.|||..:|.:|.|.::..        .|.
Mouse    87 GYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVRHLFKSIDEKKTSAIKNGLPPPEFK 151

  Fly   135 VTCSFVELYQEQFYDLFSSKTRD------KATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIR 192
            |...|:|||.|:..|||.: |||      |:.:.|.| ....|...|:|...|.:..::...|..
Mouse   152 VNAQFLELYNEEVLDLFDT-TRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTVNTEPEMMQCLKL 215

  Fly   193 GSAGRAVAATAMNETSSRSHAIFTLTLVATKL----------DGKQ----------SVTTSRFNL 237
            |:..|..|:|.||..|||||||||:.:..|::          |.|.          ...|::|:.
Mouse   216 GALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENATDNKLISESSPMNEFETLTAKFHF 280

  Fly   238 VDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYRQSKLTRLLQDSLG 301
            ||||||||..:|.|:|:|.|||::||.|||||||||:||| ..:.|.::|||.||||||||||||
Mouse   281 VDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLG 345

  Fly   302 GNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS 366
            |||.|:|||||||:|.:..|||:||:||:||..||||.:||.|..:.::|.|:..|.:|::||:.
Mouse   346 GNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELME 410

  Fly   367 GGKMSSSLISAVGAAGLGAIPCEESLAGSMAN--AAEIQRLKEQVRTLQDR-------------- 415
             .|....:|...|...:..:..|.::..:..|  ...|:.::|.|..|:.|
Mouse   411 -YKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRARITQLVSEQANQVLA 474

  Fly   416 -----NRKLQQELHQSLLDLTEKEMRAHI--AEQAHDKLRSHVS--------------------- 452
                 |.::...:|..:.::  :::||.:  :|..::.||.:::
Mouse   475 RAGEGNEEISNMIHSYIKEI--EDLRAKLLESEAVNENLRKNLTRATARSPYFSASSAFSPTILS 537

  Fly   453 -----------------ELK----------NKLDQ--REQAQFG--NENTNGDNEMRDFSLLVNR 486
                             :||          .||::  ||:....  ::|.:.|.|.::...:..:
Mouse   538 SDKETIEIIDLAKKDLEKLKRKEKKKKKRLQKLEESGREERSVAGKDDNADTDQEKKEEKGVSEK 602

  Fly   487 VHVELQRTQEELESQGHESRQRLSSRSHTEG---GESGGDEVHEMLHSHSEEYTNKQMNFAGELR 548
            .:.||. .:|..|...||..:........|.   ||...||        |:..::::.|:..:|.
Mouse   603 ENNELD-VEENQEVSDHEDEEEEEEDEEEEDDIEGEESSDE--------SDSESDEKANYQADLA 658

  Fly   549 NINRQLDLKQELHERIMRNFSRLDS--DDEDVKLRLCNQKIDDLEAERRDLMDQLRNIK--SKDI 609
            ||..::.:||:|.:.:..:..||.:  ...:.||.:...||.|.:.||..::..|.:::  |::.
Mouse   659 NITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEK 723

  Fly   610 SAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMR 674
            :.|:..|..|:|..:.:|:..|:......|.|||.:.:..::::.|..::..||::||:|::.|:
Mouse   724 AKKVKCEYEKKLHAMNKELQRLQTAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMK 788

  Fly   675 GESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLK----- 734
            .|.||.|..:..|.:|:.|||...||...::...:.....|..||:||.||..|..::::
Mouse   789 EEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDK 853

  Fly   735 -----------------DALERQASAQAQ----------------------------RHKYKDNG 754
                             |.....||.:|.                            |.||:..|
Mouse   854 VAGKVTRKLSSSESPAPDTGSSAASGEADTSRPGTQQKMRIPVARVQALPTPTTNGTRKKYQRKG 918

  Fly   755 --GSAAGSSNANAKTDSWVDRELEII---LSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPA 814
              |....|..|..|......|..:||   :::.:.|..:.:|:..|..:......|.:.:.....
Mouse   919 FTGRVFTSKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLRQREELTKRREKLSKRREKIVK 983

  Fly   815 EAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQ 879
            |:.|..:.:|::.||:|...|.|..:...:  .|..:.|..:.|..:. ||:..|      |.|
Mouse   984 ESGEGDKSVANIIEEMESLTANIDYINDSI--ADCQANIMQMEEAKEE-GETLDV------TAV- 1038

  Fly   880 QRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRT 944
               :.|.:|.|.|..||...:.         ..:|.|:..|.:.:.::|..:....|     |.:
Mouse  1039 ---INACTLTEARYLLDHFLSM---------GINKGLQAAQKEAQIKVLEGRLKQTE-----ITS 1086

  Fly   945 ANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDG 1009
            |.|              ||:|..:|..:..|..|||.|                 |..:.|.:||
Mouse  1087 ATQ--------------NQLLFHMLKEKAELNPELDAL-----------------LGHALQDLDG 1120

  Fly  1010 NETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPE------KQDANVTSLGNSSIQSLNSTSA 1068
                                             :|||      ::|..:.|.|     |..||.:
Mouse  1121 ---------------------------------APPENEEDSSEEDGPLHSPG-----SEGSTLS 1147

  Fly  1069 TEDGKRCKGCKCRTKC---TTKRCGCL--SGNNACSETCVCKSNCRNPLNLKDHASQCGDGD--G 1126
            ::..|.|...|.:.|.   ||.:...|  ..:...|:|....::...||      :...:|.  |
Mouse  1148 SDLMKLCGEVKPKNKARRRTTTQMELLYADSSEVASDTSAGDASLSGPL------APVAEGQEIG 1206

  Fly  1127 QKDETEDADKSDDDGDDEPQTSKENAVKFVTPEA-PGKVVASPKQ-TLQEPKA-AATPLMNSNVV 1188
            ...||......|.:              .:.|.. |.|:.:..:| :|.|.|. ..:|:......
Mouse  1207 MNTETSGTSARDKE--------------LLAPSGLPSKIGSISRQSSLSEKKVPEPSPVTRRKAY 1257

  Fly  1189 EDINGPK 1195
            |..:.||
Mouse  1258 EKADKPK 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	154/358 (43%)
		Kinesin	14..335	CDD:278646	154/357 (43%)
		Smc	<396..>994	CDD:224117	146/734 (20%)
		FlaC	522..633	CDD:225888	27/114 (24%)
		TCR	1075..1110	CDD:281618	8/39 (21%)
Kif21a	XP_017171930.1	KISc_KIF4	23..380	CDD:276823	154/358 (43%)
		Smc	<389..787	CDD:224117	78/409 (19%)
		SbcC	<650..>1110	CDD:223496	111/500 (22%)
		WD40	1350..1663	CDD:238121
		WD40 repeat	1401..1460	CDD:293791
		WD40 repeat	1466..1501	CDD:293791
		WD40 repeat	1506..1550	CDD:293791
		WD40 repeat	1558..1591	CDD:293791
		WD40 repeat	1598..1634	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720